Biyoloji 10. Sınıf Genel Bilgiler
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Questions and Answers

Aşağıdaki amino asitlerden hangisi, transaminasyon tepkimesine katılmaz?

  • Alanin
  • Lizin (correct)
  • Tirozin
  • Histidin

Hemoglobin oksijen bağlama yeteneğinin kaybolması, hangi durumda gerçekleşir?

  • Karbon dioksit konsantrasyonunun azalması
  • Hem yapısındaki demirin yükseltgenmesi (correct)
  • pH seviyesinin yükselmesi
  • Oksijen seviyesinin artması

Aşağıdakilerden hangisi hemoglobin yapısında bulunur?

  • Demir (correct)
  • Kalsiyum
  • Magnezyum
  • Sodyum

Transaminasyon tepkimesinde, genellikle hangi iki bileşen rol oynar?

<p>Amino asit ve alpha ketoglutarat (C)</p> Signup and view all the answers

Hangi durumda hemoglobin, oksijen taşıma kapasitesini kaybeder?

<p>pH seviyesinin düşmesi (C)</p> Signup and view all the answers

Demir yüklenilmesi ile hangi durumun ilişkisi bulunur?

<p>Hepsidin sentezinin artması (D)</p> Signup and view all the answers

β2-Mikroglobülin hangi durumda önemli bir belirteçtir?

<p>Proksimal tübül fonksiyonunun değerlendirilmesinde (D)</p> Signup and view all the answers

Aşağıdakilerden hangisi immünglobülin sınıflarından biri değildir?

<p>IgC (A)</p> Signup and view all the answers

Poliklonal gamopati durumları arasında hangisi yer almaz?

<p>Akut bakteriyel enfeksiyonlar (C)</p> Signup and view all the answers

İmmünglobülin artışları hangi koşullar altında poliklonal gamopati olarak tanımlanır?

<p>İki veya daha fazla immünglobülin türü aynı anda arttığında (A)</p> Signup and view all the answers

Marfan sendromu ile ilgili olarak doğru olan ifade hangisidir?

<p>Marfan sendromunda elastik liflerdeki bozukluk, ana sorun olarak kabul edilir. (A)</p> Signup and view all the answers

Marfan sendromu belirtileri arasında hangisi yer almaz?

<p>Osteoporoz (C)</p> Signup and view all the answers

Elastin hakkında aşağıdaki ifadelerden hangisi doğrudur?

<p>Elastin tek tip ve hidroksilizin içermez. (B)</p> Signup and view all the answers

Marfan sendromunun temel nedenlerinden biri nedir?

<p>Elastik liflerin defekti (A)</p> Signup and view all the answers

Marfan sendromunda görülen bir özellik nedir?

<p>İnce ve uzun ekstremiteler (D)</p> Signup and view all the answers

Eritrositte bulunan ve methemoglobin oluşumunu önleyen enzim hangisidir?

<p>NADH-Sitokrom b5 redüktaz (B)</p> Signup and view all the answers

Siyanür zehirlenmesinde amil nitrit verilerek demirin hangi hali elde edilmektedir?

<p>Fe +3 (A)</p> Signup and view all the answers

Methemoglobin siyanürü bağladığında hangi bileşik oluşur?

<p>Siyanomethemoglobin (C)</p> Signup and view all the answers

Siyanür zehirlenmesinde hastaya ikinci aşamada hangi madde verilir?

<p>Tiyosülfat (D)</p> Signup and view all the answers

Methemoglobinemiyi düzeltmek için hangi madde kullanılır?

<p>Metilen mavisi (B)</p> Signup and view all the answers

Spermidin ve spermin hangi madde ile ilişkilidir?

<p>Ornitin (D)</p> Signup and view all the answers

Karnozin hangi iki amino asidin birleşiminden oluşmaktadır?

<p>Histidin ve Alanin (A)</p> Signup and view all the answers

Homokarnozin hangi amino asitlerden türetilmektedir?

<p>Histidin ve GABA (A)</p> Signup and view all the answers

Nükleotit yapısında yer alan pirimidin bazları hangi amino asitlerle sentezlenir?

<p>Glutamin ve Aspartat (D)</p> Signup and view all the answers

Putressin hangi işlem sonucunda elde edilir?

<p>Ornitin dekarboksilasyonu (D)</p> Signup and view all the answers

Flashcards

What happens to hemoglobin when iron in heme is oxidized?

The iron in heme is oxidized, preventing hemoglobin from binding to oxygen.

Which amino acids undergo transamination?

Alanine, histidine, tyrosine, and leucine amino acids undergo transamination. Lysine amino acid does not.

Where is β2-microglobulin found and what's its role?

β2-Microglobulin is found in all nucleated cells. It is completely reabsorbed and catabolized by the proximal tubules. It is used as an indicator of proximal tubule function.

What are immunoglobulins and what are their classes?

Immunoglobulins are antibodies, which are proteins that function in the immune system. They are divided into five classes: IgA, IgD, IgE, IgG, and IgM.

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What is polyclonal gammopathy?

Two or more immunoglobulins are elevated, indicating a variety of conditions like viral hepatitis, sarcoidosis, rheumatoid arthritis, or chronic infections.

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What is Marfan syndrome?

Marfan syndrome is a disorder affecting elastic fibers, not collagen. It is caused by a defect in fibrillin. Individuals with Marfan syndrome exhibit long limbs, dislocated lenses, skeletal muscle deformities, and aortic aneurysms.

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What are the characteristics of elastin?

Elastin is a protein primarily found in connective tissue. It's different from collagen and does not contain hydroxylysine. It lacks carbohydrates and contains cross-links involving lysine.

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What enzyme prevents methemoglobin formation?

NADH-cytochrome b5 reductase is an enzyme found in red blood cells that prevents the formation of methemoglobin.

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How do you treat cyanide poisoning?

In cyanide poisoning, amyl nitrite is administered. It converts iron to Fe+3, leading to the formation of methemoglobin which binds to cyanide, creating cyanomethemoglobin. Thiosulfate is then given to convert cyanide to thiocyanate, which is excreted from the body. Methylene blue is used to correct methemoglobinemia.

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How are spermidine and spermine synthesized?

Spermidine and spermine are synthesized from ornithine using SAM. Putrescine, spermine, and spermidine are indicators of cell proliferation.

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What is carnosine, its components, and its role?

Carnosine is formed from histidine and alanine. It is found in muscles and is linked to olfaction. It turns into anserine with SAM.

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What and where is homocarnosine?

Homocarnosine is synthesized from histidine and GABA and functions as a neurotransmitter in the brain.

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What are purine bases and how are they synthesized?

Purine bases are synthesized from glycine, glutamine, aspartate, THF, and CO2. They are present in nucleotides.

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What are pyrimidine bases and how are they synthesized?

Pyrimidine bases are synthesized from glutamine and aspartate. They are present in nucleotides.

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What is carnitine and its function?

Carnitine is synthesized from methionine and lysine. It plays a crucial role in the transport of fatty acids from cytosol to mitochondria.

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Where are amino acid derivative compounds synthesized?

Amino acid derivative compounds are not synthesized in ribosomes. They are formed through various enzymatic reactions and modifications of amino acids.

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What is transamination?

Transamination is a metabolic process where an amino group from an amino acid is transferred to a keto acid.

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What is an amino acid derivative?

An amino acid derivative is a compound derived from an amino acid. It often has a different function from the parent amino acid.

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What is methionine and its significance?

Methionine is an essential amino acid, meaning that it cannot be synthesized by the human body and must be obtained from the diet. It plays a crucial role in various processes like protein synthesis, methylation reactions, and the synthesis of cysteine.

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What is lysine and its significance?

Lysine is an essential amino acid involved in various functions including protein synthesis, collagen formation, and carnitine synthesis. It is important for growth, immune function, and overall health.

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What is glutamine and its significance?

Glutamine is a non-essential amino acid that is synthesized from glutamate. It is involved in various processes, including protein synthesis, nitrogen transport, and energy production.

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What is aspartate and its significance?

Aspartate is a non-essential amino acid that is involved in various metabolic pathways, including the urea cycle, gluconeogenesis, and the synthesis of pyrimidine nucleotides.

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What is glycine and its significance?

Glycine is a non-essential amino acid that is involved in various biological processes including protein synthesis, collagen formation, and the synthesis of purine nucleotides.

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What is THF and its significance?

THF (tetrahydrofolic acid) is a coenzyme form of folic acid, which plays a critical role in various metabolic reactions including the synthesis of amino acids, purines, and pyrimidines.

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What is the role of CO2 in biological reactions?

CO2 (carbon dioxide) is a molecule that plays a vital role in various biological processes, including respiration, photosynthesis, and the synthesis of organic molecules like purines.

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What is histidine and its significance?

Histidine is an essential amino acid that is involved in various processes including protein synthesis, the formation of histamine, and the synthesis of carnosine and homocarnosine.

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What is alanine and its significance?

Alanine is a non-essential amino acid that plays a role in the transfer of nitrogen and the synthesis of glucose.

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What is GABA and its significance?

GABA (gamma-aminobutyric acid) is an inhibitory neurotransmitter in the central nervous system, involved in regulating anxiety, sleep, and other functions.

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Study Notes

Hem Yapısındaki Demir

  • Hem yapısında demir yükseltgendiğinde, hemoglobin oksijen bağlayamaz.

Transaminasyon

  • Alanin, histidin, tirozin ve lösin amino asitleri transaminasyona girer.
  • Lizin amino asiti transaminasyona girmez.

β2-Mikroglobülin

  • β2-Mikroglobülin tüm nükleuslu hücrelerde bulunur.
  • Proksimal tübüllerde tamamen emilir ve katabolize edilir.
  • Proksimal tübül fonksiyonun değerlendirilmesinde belirteç olarak kullanılır.

İmmünglobülinler

  • İmmünglobülinler beş sınıftır: IgA, IgD, IgE, IgG ve IgM.
  • İki veya daha fazla immunglobülin aynı anda artarsa poliklonal gamopati denir.
  • Poliklonal gamopati, viral hepatit, sarkoidoz, romatoid artrit ve kronik enfeksiyonlar gibi durumlarda görülebilir.

Marfan Sendromu

  • Marfan sendromu (araknodaktili), elastik liflerde bir bozukluktur, kollajen bozukluğu değildir.
  • Fibrillin defektine bağlı olarak görülür.
  • Hastalarda ince ve uzun ekstremiteler, lens subluksasyonu, iskelet kası deformiteleri ve aort anevrizması görülür.

Elastin

  • Elastin, hidroksilizin içermez.
  • Tek tiptir ve karbonhidrat içermez.
  • Yapısında çapraz bağlar, lizin içerir.
  • Kollajenden farklıdır.

Methemoglobin oluşumunu önleyen enzim

  • Eritrositte bulunan ve methemoglobin oluşumunu önleyen enzim, NADH-Sitokrom b5 redüktaz'dır.

Siyanür Zehirlenmesi

  • Siyanür zehirlenmesinde amil nitrit verilir.
  • Amil nitrit, demiri Fe +3 haline getirir.
  • Methemoglobin siyanürü bağlayarak siyanomethemoglobin oluşturur.
  • İkinci aşamada tiyosülfat verilir.
  • Siyanür, tiyosiyanat şeklinde vücuttan atılır.
  • Methemoglobinemiyi düzeltmek için metilen mavisi kullanılır.

Poliaminler

  • Spermidin ve spermin, ornitinden SAM ile sentezlenir.
  • Putressin, spermin ve spermidin, hücre proliferasyon göstergeleridir.

Karnozin

  • Histidin ve alanin'den karnozin oluşur.
  • Kaslarda bulunur ve koku alma ile ilişkilidir.
  • Karnozin, SAM ile anserine dönüşür.

Homokarnozin

  • Histidin ve GABA'dan homokarnozin oluşur.
  • Beyinde nörotransmiter olarak görev alır.

Pürin Bazları

  • Glisin, glutamin, aspartat, THF ve CO2'den pürin bazları oluşur.
  • Nükleotit yapısında bulunur.

Pirimidin Bazları

  • Glutamin ve aspartattan pirimidin bazları oluşur.
  • Nükleotit yapısında bulunur.

Karnitin

  • Metiyonin ve lizinden karnitin oluşur.
  • Yağ asitlerinin sitozolden mitokondriye taşınmasında rol alır.

Amino Asit Türevi Bileşikler

  • Tabloda yer alan amino asit türevi bileşikler, ribozomda sentezlenmez.

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Description

Bu quiz, hem yapısı, transaminasyon, immünglobülinler ve Marfan sendromu gibi önemli biyolojik konuları kapsar. Öğrencilerin bu konular üzerindeki bilgilerini test etmek için hazırlanmıştır. Biyoloji 10. sınıf müfredatına uygun içerik sunar.

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