Birth Defects Overview Quiz
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Questions and Answers

What is the term used for the study of birth defects?

  • Teratology and dysmorphology (correct)
  • Embryology
  • Pediatrics
  • Genomics
  • What percentage of liveborn infants are affected by major structural anomalies?

  • 4% to 5%
  • 2% to 3% (correct)
  • 1% to 2%
  • 5% to 6%
  • What is the leading cause of infant mortality?

  • Infectious diseases
  • Birth defects (correct)
  • Accidents
  • Premature birth
  • Which group of professionals typically studies birth defects in a clinical setting?

    <p>Dysmorphologists</p> Signup and view all the answers

    What is a significant contributing factor to disabilities in children?

    <p>Birth defects</p> Signup and view all the answers

    What is the significance of vaccines in relation to rubella and birth defects?

    <p>Vaccines have reduced the incidence of birth defects from rubella.</p> Signup and view all the answers

    Which of the following infectious agents is known to frequently cause mental retardation in fetuses?

    <p>Cytomegalovirus</p> Signup and view all the answers

    Approximately what percentage of women are currently immune to rubella?

    <p>85%</p> Signup and view all the answers

    Which statement about cytomegalovirus infection in pregnant women is true?

    <p>It can be fatal to the fetus.</p> Signup and view all the answers

    Which virus is NOT mentioned as a potential cause of birth defects?

    <p>Ebola virus</p> Signup and view all the answers

    What percentage of birth defects have an unknown cause?

    <p>40% to 60%</p> Signup and view all the answers

    Which factor accounts for the highest percentage of birth defects?

    <p>Unknown causes</p> Signup and view all the answers

    What is the chance of having a major malformation in infants with two minor anomalies?

    <p>10%</p> Signup and view all the answers

    What percentage of birth defects are attributed to twinning?

    <p>0.5% to 1%</p> Signup and view all the answers

    Which type of anomalies often serve as diagnostic clues for serious underlying defects?

    <p>Minor anomalies</p> Signup and view all the answers

    What is a characteristic feature of fetal infection with Toxoplasmosis?

    <p>Presence of calcifications</p> Signup and view all the answers

    Which of the following infections is NOT associated with malformations?

    <p>Toxoplasmosis</p> Signup and view all the answers

    Which of the following is a potential source of Toxoplasmosis infection for humans?

    <p>Domestic animals, particularly cats</p> Signup and view all the answers

    What is the malformation rate following maternal infection with viruses such as measles and mumps?

    <p>Low, if not nonexistent</p> Signup and view all the answers

    What is a common transmission route for the Toxoplasmosis parasite?

    <p>Consumption of undercooked meat</p> Signup and view all the answers

    What type of abnormality is characterized by changes during the formation of structures due to genetic or environmental factors?

    <p>Malformation</p> Signup and view all the answers

    Which type of abnormality is primarily caused by mechanical forces affecting the fetus over time?

    <p>Deformation</p> Signup and view all the answers

    What is an example of a disruption caused by destructive processes?

    <p>Vascular accidents</p> Signup and view all the answers

    During which weeks of gestation do most malformations originate?

    <p>Third to eighth weeks</p> Signup and view all the answers

    Which abnormality is typically reversible after birth?

    <p>Deformation</p> Signup and view all the answers

    What type of cells does ionizing radiation primarily affect, leading to the potential for birth defects?

    <p>Rapidly proliferating cells</p> Signup and view all the answers

    What percentage of women who were pregnant during the Hiroshima and Nagasaki atomic bomb explosions gave birth to children with severe birth defects involving the central nervous system?

    <p>25%</p> Signup and view all the answers

    Which statement accurately reflects the mutagenic effect of radiation?

    <p>It can lead to genetic alteration of germ cells.</p> Signup and view all the answers

    During what stage of development can ionizing radiation produce birth defects?

    <p>At any stage of development</p> Signup and view all the answers

    What defines a syndrome?

    <p>A collection of anomalies that have a specific common cause.</p> Signup and view all the answers

    What is the main difference between a syndrome and an association?

    <p>Syndromes have a known cause while associations do not.</p> Signup and view all the answers

    What was the percentage of women who aborted after the atomic bomb explosions in Hiroshima and Nagasaki?

    <p>28%</p> Signup and view all the answers

    Which of the following is an example of an association?

    <p>VACTERL association</p> Signup and view all the answers

    Why is recognizing associations important?

    <p>It promotes the search for other abnormalities in the group.</p> Signup and view all the answers

    Which of the following statements is true regarding anomalies?

    <p>A syndrome confirms the recurrence of anomalies based on a known cause.</p> Signup and view all the answers

    Which factor primarily influences the susceptibility to teratogenesis in an individual?

    <p>Genotype of the conceptus</p> Signup and view all the answers

    During which stage of gestation is susceptibility to teratogens highest?

    <p>Third to eighth weeks of gestation</p> Signup and view all the answers

    Which of the following manifestations of abnormal development is NOT commonly associated with teratogenic exposure?

    <p>Genetic mutation</p> Signup and view all the answers

    What is a likely mechanism by which teratogens cause abnormal embryogenesis?

    <p>Inhibiting specific biochemical processes</p> Signup and view all the answers

    Which of these factors does NOT influence the manifestations of abnormal development in a teratogenic context?

    <p>Parental occupation</p> Signup and view all the answers

    What makes it challenging to assess the impact of chemical agents on human abnormalities?

    <p>Retrospective studies relying on maternal memory and multiple drug use</p> Signup and view all the answers

    Which of the following drugs has been identified as teratogenic?

    <p>Thalidomide</p> Signup and view all the answers

    Which abnormality was notably associated with thalidomide use during pregnancy?

    <p>Amelia and meromelia</p> Signup and view all the answers

    What is a primary reason why the teratogenic effects of some drugs may go unnoticed?

    <p>Connection to more common abnormalities not being recognized</p> Signup and view all the answers

    What factor contributes to the difficulty in identifying the effects of pharmaceutical drugs during pregnancy?

    <p>Lack of detailed records on drug histories of mothers</p> Signup and view all the answers

    Study Notes

    Other Viral Infections and Hyperthermia

    • Malformations following maternal infection with measles, mumps, hepatitis, polio, echovirus, and Coxsackie virus, and influenza virus have been described.
    • Prospective studies show that the malformation rate after exposure to these agents is low if not nonexistent.
    • Toxoplasmosis and syphilis cause birth defects. Poorly cooked meat, domestic animals (especially cats), and feces in contaminated soil can carry the protozoan parasite Toxoplasma gondii.
    • A characteristic feature of fetal toxoplasmosis infection is calcifications.

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    Description

    Test your knowledge on the study of birth defects, including their causes, occurrence, and implications on infant health. Explore various factors contributing to disabilities and the significance of vaccination in preventing these conditions. This quiz is essential for anyone interested in pediatric health and developmental biology.

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