Biotin and Pyruvate Carboxylation Quiz
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Questions and Answers

Which vitamin is required for pyruvate carboxylase?

  • Vitamin A
  • Vitamin C
  • Vitamin B7 (correct)
  • Vitamin D

    • What is the product of the carboxylation of pyruvate by pyruvate carboxylase?

  • Malate
  • Oxaloacetate (correct)
  • Acetyl-CoA
  • Phosphoenolpyruvate

    • Why is OAA reduced to malate?

  • OAA can't cross the mitochondrial membrane (correct)
  • Malate is a more stable molecule
  • Malate is required by PEP carboxykinase
  • OAA is toxic to the cell

    • Which enzyme oxidatively decarboxylates oxaloacetate to phosphoenolpyruvate?

    <p>PEP carboxykinase</p> Signup and view all the answers

    What is the role of avidin in biotin absorption?

    <p>It binds to biotin and prevents its absorption</p> Signup and view all the answers

    Which food source is a good source of avidin?

    <p>Egg whites</p> Signup and view all the answers

    What is the consequence of biotin deficiency?

    <p>All of the above</p> Signup and view all the answers

    What is the function of ATP in the carboxylation of pyruvate?

    <p>It drives the formation of high-energy enzyme-biotin-CO2 intermediate</p> Signup and view all the answers

    What is the fate of malate produced in the mitochondria?

    <p>It is transported to the cytosol</p> Signup and view all the answers

    What is the final product of the oxidative decarboxylation of OAA?

    <p>Phosphoenolpyruvate</p> Signup and view all the answers

    Which vitamin is required for pyruvate carboxylase?

    <p>Vitamin B7</p> Signup and view all the answers

    What is the product of the carboxylation of pyruvate by pyruvate carboxylase?

    <p>Oxaloacetate</p> Signup and view all the answers

    Why is OAA reduced to malate?

    <p>OAA can't cross the mitochondrial membrane</p> Signup and view all the answers

    Which enzyme oxidatively decarboxylates oxaloacetate to phosphoenolpyruvate?

    <p>PEP carboxykinase</p> Signup and view all the answers

    What is the role of avidin in biotin absorption?

    <p>It binds to biotin and prevents its absorption</p> Signup and view all the answers

    Which food source is a good source of avidin?

    <p>Egg whites</p> Signup and view all the answers

    What is the consequence of biotin deficiency?

    <p>All of the above</p> Signup and view all the answers

    What is the function of ATP in the carboxylation of pyruvate?

    <p>It drives the formation of high-energy enzyme-biotin-CO2 intermediate</p> Signup and view all the answers

    What is the fate of malate produced in the mitochondria?

    <p>It is transported to the cytosol</p> Signup and view all the answers

    What is the final product of the oxidative decarboxylation of OAA?

    <p>Phosphoenolpyruvate</p> Signup and view all the answers

    Which molecule is carboxylated to form oxaloacetate by pyruvate carboxylase?

    <p>Pyruvate</p> Signup and view all the answers

    What is the fate of oxaloacetate produced by pyruvate carboxylase?

    <p>It is reduced to malate</p> Signup and view all the answers

    What is the role of PEP carboxykinase in the process of pyruvate carboxylation?

    <p>It decarboxylates oxaloacetate to PEP</p> Signup and view all the answers

    What is the relationship between avidin and biotin?

    <p>They bind to each other</p> Signup and view all the answers

    Why is it important to cook egg whites before consuming them?

    <p>To denature avidin</p> Signup and view all the answers

    What is biotin also known as?

    <p>Vitamin H</p> Signup and view all the answers

    What drives the formation of the high-energy enzyme-biotin-CO2 intermediate in pyruvate carboxylation?

    <p>ATP</p> Signup and view all the answers

    What is the end product of the oxidative decarboxylation of oxaloacetate by PEP carboxykinase?

    <p>Phosphoenolpyruvate</p> Signup and view all the answers

    What happens when there is a lack of biotin in the body?

    <p>Pyruvate carboxylation is inhibited</p> Signup and view all the answers

    Where does the reduction of malate to oxaloacetate occur in the process of pyruvate carboxylation?

    <p>Mitochondria</p> Signup and view all the answers

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