30 Questions
Which vitamin is required for pyruvate carboxylase?
Vitamin B7
What is the product of the carboxylation of pyruvate by pyruvate carboxylase?
Oxaloacetate
Why is OAA reduced to malate?
OAA can't cross the mitochondrial membrane
Which enzyme oxidatively decarboxylates oxaloacetate to phosphoenolpyruvate?
PEP carboxykinase
What is the role of avidin in biotin absorption?
It binds to biotin and prevents its absorption
Which food source is a good source of avidin?
Egg whites
What is the consequence of biotin deficiency?
All of the above
What is the function of ATP in the carboxylation of pyruvate?
It drives the formation of high-energy enzyme-biotin-CO2 intermediate
What is the fate of malate produced in the mitochondria?
It is transported to the cytosol
What is the final product of the oxidative decarboxylation of OAA?
Phosphoenolpyruvate
Which vitamin is required for pyruvate carboxylase?
Vitamin B7
What is the product of the carboxylation of pyruvate by pyruvate carboxylase?
Oxaloacetate
Why is OAA reduced to malate?
OAA can't cross the mitochondrial membrane
Which enzyme oxidatively decarboxylates oxaloacetate to phosphoenolpyruvate?
PEP carboxykinase
What is the role of avidin in biotin absorption?
It binds to biotin and prevents its absorption
Which food source is a good source of avidin?
Egg whites
What is the consequence of biotin deficiency?
All of the above
What is the function of ATP in the carboxylation of pyruvate?
It drives the formation of high-energy enzyme-biotin-CO2 intermediate
What is the fate of malate produced in the mitochondria?
It is transported to the cytosol
What is the final product of the oxidative decarboxylation of OAA?
Phosphoenolpyruvate
Which molecule is carboxylated to form oxaloacetate by pyruvate carboxylase?
Pyruvate
What is the fate of oxaloacetate produced by pyruvate carboxylase?
It is reduced to malate
What is the role of PEP carboxykinase in the process of pyruvate carboxylation?
It decarboxylates oxaloacetate to PEP
What is the relationship between avidin and biotin?
They bind to each other
Why is it important to cook egg whites before consuming them?
To denature avidin
What is biotin also known as?
Vitamin H
What drives the formation of the high-energy enzyme-biotin-CO2 intermediate in pyruvate carboxylation?
ATP
What is the end product of the oxidative decarboxylation of oxaloacetate by PEP carboxykinase?
Phosphoenolpyruvate
What happens when there is a lack of biotin in the body?
Pyruvate carboxylation is inhibited
Where does the reduction of malate to oxaloacetate occur in the process of pyruvate carboxylation?
Mitochondria
Test your knowledge on the role of biotin in pyruvate carboxylation with this quiz! Learn about the formation of the enzyme-biotin-CO2 intermediate and how it carboxylates pyruvate to oxaloacetate. Explore the process of reducing oxaloacetate to malate and re-oxidizing it in the cytosol. Finally, understand how this process leads to the formation of phosphoenolpyruvate through PEP carbox
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