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Questions and Answers
What is the rigorous scientific methodology used in safety testing?
What is the rigorous scientific methodology used in safety testing?
- Phase testing (correct)
- Experimental testing
- Clinical testing
- Controlled testing
Why are two or more species used in safety testing?
Why are two or more species used in safety testing?
- To reveal different effects that may be seen in different animals (correct)
- To simplify the regulatory requirements
- To speed up the testing process
- To reduce the cost of testing
What are researchers tasked with achieving in animal research?
What are researchers tasked with achieving in animal research?
- The Five Ps: Protection, Prevention, Promotion, Participation
- The Two Es: Ethical Examination
- The Four Cs: Care, Control, Compliance, Credibility
- The Three Rs: Reduce, Refine, Replace (correct)
What are the alternatives to the use of animal models mentioned in the text?
What are the alternatives to the use of animal models mentioned in the text?
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When are human research participants recruited for trials?
When are human research participants recruited for trials?
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Study Notes
Safety Testing Methodology
- Rigorous scientific methodology used in safety testing involves a hierarchical approach, starting with in vitro and in silico methods, followed by animal testing, and finally, human clinical trials.
Animal Testing
- Two or more species are used in safety testing to ensure that the results are not specific to a single species and to increase the reliability of the data.
- Researchers are tasked with achieving a reduction in the number of animals used, refinement of the testing procedures to minimize animal suffering, and replacement of animals with alternative models whenever possible.
Alternatives to Animal Models
- Alternatives to the use of animal models mentioned in the text include in vitro methods, such as cell cultures and tissue engineering, and in silico methods, such as computer simulations and modeling.
Human Research Participants
- Human research participants are recruited for trials once the safety and efficacy of a substance or product have been established in animal testing and other preclinical studies.
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Test your knowledge on medical advances made using animal research models, ethical concerns about using animals in research, alternatives to animal models, and products produced using transgenic animals as bioreactors.
