Biosynthesis of β-Carboline Alkaloids

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which type of alkaloids form a small group of tryptamine derivatives?

  • Pyrolo-indole alkaloids (correct)
  • Isoprenoid indole alkaloids
  • Ergot alkaloids
  • Vinca alkaloids

What is the biosynthetic pathway for β-carboline alkaloids?

  • Formation of amine from tryptamine and aldehyde
  • Methylation of indole at position 3
  • Schiff base formation from tryptamine and aldehyde followed by intramolecular Mannich reaction (correct)
  • Addition of an ethylamino group to the indole nucleus

What is the key feature of Isoprenoid indole alkaloids?

  • Derivation from tryptamine and isoprenoid building blocks (correct)
  • Methylation at position 3 of the indole nucleus
  • Addition of an ethylamino group at C2
  • Formation of a Schiff base

Which plant family does Rauwolfia serpentina belong to?

<p>Apocynaceae (C)</p> Signup and view all the answers

Which alkaloid is used as an antihypertensive and tranquilizer?

<p>Reserpine (A)</p> Signup and view all the answers

What is the general characteristic of Strong anhydronium bases like Serpentine?

<p>Highly basic compounds containing nitrogen (C)</p> Signup and view all the answers

What is the biochemical precursor of indole alkaloids?

<p>The amino acid tryptophan (D)</p> Signup and view all the answers

How are isoprenoid and non-isoprenoid indole alkaloids distinguished?

<p>By their biosynthetic pathways (B)</p> Signup and view all the answers

Which of the following is a non-isoprenoid indole alkaloid?

<p>Tryptamine (C)</p> Signup and view all the answers

Which of the following is NOT a Rauwolfia alkaloid?

<p>Vincristine (B)</p> Signup and view all the answers

What is the first synthesis step in the formation of DMT and psilocybin from tryptophan?

<p>Decarboxylation (C)</p> Signup and view all the answers

Which coenzyme participates in the methylation of tryptamine to form DMT?

<p>S-adenosyl methionine (SAM) (D)</p> Signup and view all the answers

What is the common structural feature of Rauwolfia alkaloids?

<p>They are derived from tryptophan and corynanthe-type monoterpenoid precursors (D)</p> Signup and view all the answers

What is the primary mechanism of action responsible for the antihypertensive effects of reserpine?

<p>Depletion of catecholamines from peripheral sympathetic nerve endings (B)</p> Signup and view all the answers

Which of the following compounds is formed by the oxidation of DMT?

<p>Psilocin (C)</p> Signup and view all the answers

Which of the following alkaloids from Catharanthus roseus (Vinca) has anti-neoplastic activity?

<p>Vincristine (A)</p> Signup and view all the answers

What is the primary mechanism of action for the anti-neoplastic effects of vincristine and vinblastine?

<p>Inhibition of tubulin polymerization and microtubule assembly (B)</p> Signup and view all the answers

Which of the following is a common structural feature shared by Rauwolfia alkaloids and the anti-neoplastic Vinca alkaloids?

<p>They contain indole and dihydroindole rings (B)</p> Signup and view all the answers

Flashcards are hidden until you start studying

More Like This

β-Lactam Antibiotics Overview
18 questions
β-Lactam Antibiotics Quiz
48 questions

β-Lactam Antibiotics Quiz

AffirmativeClematis8115 avatar
AffirmativeClematis8115
Use Quizgecko on...
Browser
Browser