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Biopharmaceuticals in Cancer Treatment

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Questions and Answers

What is one of the causes of failure in beating cancer with current drugs?

Easy intracellular delivery of high MW and hydrophilic molecules

Rapid elimination of the active compound from the target site (correct)

Accumulation of the drug at the target site being the rule rather than the exception

Detoxification of the drug at the target site

What is the main problem associated with many therapeutic proteins in terms of intracellular delivery?

They accumulate at the target site

They do not enter cells easily (correct)

They have low molecular weight (MW)

They are highly hydrophobic

What is the purpose of increasing the therapeutic index of drugs through drug targeting?

To rapidly eliminate the active compound from the target site

To specifically deliver the active compound to its site of action and keep it there until inactivated and detoxified (correct)

To prevent accumulation of the drug at the target site

To distribute the drug over non-target organs to exert side effects

Which type of biopharmaceuticals have been developed and applied to treat various cancers?

Monoclonal antibodies (MAbs), non-antibody proteins, and small molecules Signup and view all the answers

Which of the following is NOT a core pathway targeted by biopharmaceuticals for cancer treatment?

Tyrosin kinases Signup and view all the answers

Which antigen is targeted by Rituximab in the treatment of non-Hodgkin lymphoma and chronic lymphocytic leukemia?

CD20 Signup and view all the answers

What is the primary function of monoclonal antibodies (MAbs) in killing cancer cells directly?

Inhibiting signaling, reducing proliferation, inducing apoptosis Signup and view all the answers

What is a potential challenge in targeting tumors with monoclonal antibodies (MAbs)?

Antigen modulation Signup and view all the answers

What is the main reason biopharmaceuticals are becoming a potential treatment for cancer?

Specificity in targeting cancer cells with various options Signup and view all the answers

Which growth factor supports the formation of microvasculature and is an example of a target for biopharmaceuticals?

Vascular endothelial growth factor (VEGF) Signup and view all the answers