10 Questions
What is one of the causes of failure in beating cancer with current drugs?
Rapid elimination of the active compound from the target site
What is the main problem associated with many therapeutic proteins in terms of intracellular delivery?
They do not enter cells easily
What is the purpose of increasing the therapeutic index of drugs through drug targeting?
To specifically deliver the active compound to its site of action and keep it there until inactivated and detoxified
Which type of biopharmaceuticals have been developed and applied to treat various cancers?
Monoclonal antibodies (MAbs), non-antibody proteins, and small molecules
Which of the following is NOT a core pathway targeted by biopharmaceuticals for cancer treatment?
Tyrosin kinases
Which antigen is targeted by Rituximab in the treatment of non-Hodgkin lymphoma and chronic lymphocytic leukemia?
CD20
What is the primary function of monoclonal antibodies (MAbs) in killing cancer cells directly?
Inhibiting signaling, reducing proliferation, inducing apoptosis
What is a potential challenge in targeting tumors with monoclonal antibodies (MAbs)?
Antigen modulation
What is the main reason biopharmaceuticals are becoming a potential treatment for cancer?
Specificity in targeting cancer cells with various options
Which growth factor supports the formation of microvasculature and is an example of a target for biopharmaceuticals?
Vascular endothelial growth factor (VEGF)
This quiz covers the molecular targets of biopharmaceuticals used in cancer treatment, including monoclonal antibodies and small molecules. It also explores the reasons for the limited success in treating cancer with current drugs.
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