Podcast
Questions and Answers
What is one of the causes of failure in beating cancer with current drugs?
What is one of the causes of failure in beating cancer with current drugs?
- Easy intracellular delivery of high MW and hydrophilic molecules
- Rapid elimination of the active compound from the target site (correct)
- Accumulation of the drug at the target site being the rule rather than the exception
- Detoxification of the drug at the target site
What is the main problem associated with many therapeutic proteins in terms of intracellular delivery?
What is the main problem associated with many therapeutic proteins in terms of intracellular delivery?
- They accumulate at the target site
- They do not enter cells easily (correct)
- They have low molecular weight (MW)
- They are highly hydrophobic
What is the purpose of increasing the therapeutic index of drugs through drug targeting?
What is the purpose of increasing the therapeutic index of drugs through drug targeting?
- To rapidly eliminate the active compound from the target site
- To specifically deliver the active compound to its site of action and keep it there until inactivated and detoxified (correct)
- To prevent accumulation of the drug at the target site
- To distribute the drug over non-target organs to exert side effects
Which type of biopharmaceuticals have been developed and applied to treat various cancers?
Which type of biopharmaceuticals have been developed and applied to treat various cancers?
Which of the following is NOT a core pathway targeted by biopharmaceuticals for cancer treatment?
Which of the following is NOT a core pathway targeted by biopharmaceuticals for cancer treatment?
Which antigen is targeted by Rituximab in the treatment of non-Hodgkin lymphoma and chronic lymphocytic leukemia?
Which antigen is targeted by Rituximab in the treatment of non-Hodgkin lymphoma and chronic lymphocytic leukemia?
What is the primary function of monoclonal antibodies (MAbs) in killing cancer cells directly?
What is the primary function of monoclonal antibodies (MAbs) in killing cancer cells directly?
What is a potential challenge in targeting tumors with monoclonal antibodies (MAbs)?
What is a potential challenge in targeting tumors with monoclonal antibodies (MAbs)?
What is the main reason biopharmaceuticals are becoming a potential treatment for cancer?
What is the main reason biopharmaceuticals are becoming a potential treatment for cancer?
Which growth factor supports the formation of microvasculature and is an example of a target for biopharmaceuticals?
Which growth factor supports the formation of microvasculature and is an example of a target for biopharmaceuticals?
Flashcards are hidden until you start studying
