Podcast
Questions and Answers
Which technology is used to create an artificial vestibular system?
Which technology is used to create an artificial vestibular system?
- Quantum computing
- Nanotechnology
- Laser technology
- MEMS technology and 3D printing (correct)
The biomimetic semicircular canal has no similarity in dimensions or mechanisms to a human semicircular canal.
The biomimetic semicircular canal has no similarity in dimensions or mechanisms to a human semicircular canal.
False (B)
What is the primary purpose of biomimetic balance sensors?
What is the primary purpose of biomimetic balance sensors?
To restore balance using mechanisms that mimic biological systems.
The primary sensory mechanism for detecting odor is called _____
The primary sensory mechanism for detecting odor is called _____
Who conducted research on the development of a biomimetic semicircular canal?
Who conducted research on the development of a biomimetic semicircular canal?
Sensor arrays based on biomimetic recognition and chemometrics can be used in artificial olfaction.
Sensor arrays based on biomimetic recognition and chemometrics can be used in artificial olfaction.
What is the main physiological function of gustation?
What is the main physiological function of gustation?
Match the following components with their respective functions:
Match the following components with their respective functions:
What type of sensors are used to measure changes in mass through protein oscillations?
What type of sensors are used to measure changes in mass through protein oscillations?
Surface Plasmon Resonance is highly accurate for detecting small organic compounds.
Surface Plasmon Resonance is highly accurate for detecting small organic compounds.
What device is developed using interdigitated electrodes coated with OBPs?
What device is developed using interdigitated electrodes coated with OBPs?
The vibration theory of biological olfaction is used in __________-based biomimetic odor classification.
The vibration theory of biological olfaction is used in __________-based biomimetic odor classification.
Match the following sensor types with their characteristics:
Match the following sensor types with their characteristics:
Which of the following is a disadvantage of Surface Plasmon Resonance?
Which of the following is a disadvantage of Surface Plasmon Resonance?
What is a major problem associated with metal oxide gas sensors?
What is a major problem associated with metal oxide gas sensors?
Graphene-based materials are currently considered expensive alternatives in gas sensing.
Graphene-based materials are currently considered expensive alternatives in gas sensing.
Olfactory receptors can be immobilized on a prism as part of optical sensors.
Olfactory receptors can be immobilized on a prism as part of optical sensors.
What are the primary advantages of using soluble binding proteins in gas sensing?
What are the primary advantages of using soluble binding proteins in gas sensing?
What is the role of OBPs in electric sensors?
What is the role of OBPs in electric sensors?
Olfactory receptors are designed to mimic the _______ nose.
Olfactory receptors are designed to mimic the _______ nose.
Which conducting polymer offers the highest selectivity in gas response?
Which conducting polymer offers the highest selectivity in gas response?
Match the types of gas sensors with their characteristics:
Match the types of gas sensors with their characteristics:
Soluble binding proteins have high selectivity for hydrophobic ligands.
Soluble binding proteins have high selectivity for hydrophobic ligands.
What theory inspired the quantum biomimetic electronic nose sensor?
What theory inspired the quantum biomimetic electronic nose sensor?
Metal oxides need to be heated to _________ °C to regenerate.
Metal oxides need to be heated to _________ °C to regenerate.
Taste receptor cells are only connected to one type of taste quality.
Taste receptor cells are only connected to one type of taste quality.
How many taste receptor cells does each taste bud contain?
How many taste receptor cells does each taste bud contain?
The tongue has tens of thousands of ______ buds.
The tongue has tens of thousands of ______ buds.
What is a key characteristic of nerve fibers connected to taste cells?
What is a key characteristic of nerve fibers connected to taste cells?
Match the basic tastes with their descriptions:
Match the basic tastes with their descriptions:
What is the main function of the brain in taste perception?
What is the main function of the brain in taste perception?
Taste sensation occurs when specific signals are generated by taste buds stimulated by tastants.
Taste sensation occurs when specific signals are generated by taste buds stimulated by tastants.
What is a primary challenge in dealing with chemical senses?
What is a primary challenge in dealing with chemical senses?
A biomimetic smell sensor uses chemical cues to recognize smells.
A biomimetic smell sensor uses chemical cues to recognize smells.
Name one method used to develop taste sensors.
Name one method used to develop taste sensors.
The structure that helps to analyze taste in biomimetic systems is called a _____ sensor.
The structure that helps to analyze taste in biomimetic systems is called a _____ sensor.
Match the following sensors with their types:
Match the following sensors with their types:
Which principle combines biomimetic recognition and chemometrics in sensor design?
Which principle combines biomimetic recognition and chemometrics in sensor design?
Biomimetic sensors are used only for the sense of smell.
Biomimetic sensors are used only for the sense of smell.
Briefly describe how a biomimetic smell sensor works.
Briefly describe how a biomimetic smell sensor works.
How many olfactory receptors do humans possess?
How many olfactory receptors do humans possess?
Specific anosmia refers to the ability to detect a wide range of odors.
Specific anosmia refers to the ability to detect a wide range of odors.
What is the term used to describe the model that allows for the discrimination of millions of odors with limited receptors?
What is the term used to describe the model that allows for the discrimination of millions of odors with limited receptors?
The responses of the olfactory receptors generate unique odor pictures in the olfactory __________.
The responses of the olfactory receptors generate unique odor pictures in the olfactory __________.
Match the features with their correct descriptions:
Match the features with their correct descriptions:
What ensures that important odors can still be detected despite random mutations?
What ensures that important odors can still be detected despite random mutations?
The olfactory system is often compared to __________ and __________ in its complexity.
The olfactory system is often compared to __________ and __________ in its complexity.
What effect does the olfactory processing have on behavioral responses?
What effect does the olfactory processing have on behavioral responses?
What is the olfactory threshold?
What is the olfactory threshold?
Humans have more olfactory receptors than most animals.
Humans have more olfactory receptors than most animals.
Name one of the three steps involved in translating chemical information into measurable parameters in an artificial nose.
Name one of the three steps involved in translating chemical information into measurable parameters in an artificial nose.
The artificial nose uses __________ to recognize specific response profiles associated with different odors.
The artificial nose uses __________ to recognize specific response profiles associated with different odors.
What is a primary feature that biological noses use to discriminate odors?
What is a primary feature that biological noses use to discriminate odors?
Match the following components with their primary function in artificial noses:
Match the following components with their primary function in artificial noses:
What is the typical number of olfactory receptors present in humans?
What is the typical number of olfactory receptors present in humans?
Physiological coding in noses is similar to how letters form words.
Physiological coding in noses is similar to how letters form words.
What is a major advantage of conducting polymers in gas sensing?
What is a major advantage of conducting polymers in gas sensing?
Metal oxide sensors are highly selective and can quickly regenerate their response.
Metal oxide sensors are highly selective and can quickly regenerate their response.
What temperature do metal oxide gas sensors need to be heated to for regeneration?
What temperature do metal oxide gas sensors need to be heated to for regeneration?
Olfactory receptors are ideal for __________ the human nose.
Olfactory receptors are ideal for __________ the human nose.
What is a limitation of soluble binding proteins (OBPs) in gas sensing?
What is a limitation of soluble binding proteins (OBPs) in gas sensing?
Match the following types of sensors with their primary characteristic:
Match the following types of sensors with their primary characteristic:
Graphene-based materials are considered more expensive alternatives in gas sensing than metal oxides.
Graphene-based materials are considered more expensive alternatives in gas sensing than metal oxides.
What do soluble binding proteins (OBPs) provide for odorants?
What do soluble binding proteins (OBPs) provide for odorants?
What is the main function of the 300 receptors in the human olfactory system?
What is the main function of the 300 receptors in the human olfactory system?
Specific anosmia refers to the complete inability to detect all odors.
Specific anosmia refers to the complete inability to detect all odors.
How do olfactory receptors achieve the ability to discriminate millions of odors with limited receptors?
How do olfactory receptors achieve the ability to discriminate millions of odors with limited receptors?
Match the following terms with their descriptions:
Match the following terms with their descriptions:
What is a key characteristic of the olfactory receptors?
What is a key characteristic of the olfactory receptors?
The human olfactory system has 500 receptors.
The human olfactory system has 500 receptors.
What is generated by processing the responses of the olfactory receptors?
What is generated by processing the responses of the olfactory receptors?
Taste receptor cells are only connected to multiple taste quality types.
Taste receptor cells are only connected to multiple taste quality types.
A biomimetic smell sensor uses __________ cues to recognize smells.
A biomimetic smell sensor uses __________ cues to recognize smells.
Match the following types of sensory sensors with their primary functions:
Match the following types of sensory sensors with their primary functions:
Which sensory system is commonly inspired by biomimetic designs?
Which sensory system is commonly inspired by biomimetic designs?
Humans possess over 400 types of olfactory receptors.
Humans possess over 400 types of olfactory receptors.
What is the main role of soluble binding proteins in chemical sensing?
What is the main role of soluble binding proteins in chemical sensing?
What type of sensors measure changes in frequency when a ligand binds to a protein?
What type of sensors measure changes in frequency when a ligand binds to a protein?
Optical sensors are highly accurate for detecting small organic compounds.
Optical sensors are highly accurate for detecting small organic compounds.
What is the primary purpose of electric sensors in biomimetic olfactory systems?
What is the primary purpose of electric sensors in biomimetic olfactory systems?
Surface Plasmon Resonance sensors immobilize olfactory receptors on a _____ to detect changes.
Surface Plasmon Resonance sensors immobilize olfactory receptors on a _____ to detect changes.
Which method is used in vibration-based biomimetic odor classification?
Which method is used in vibration-based biomimetic odor classification?
Biomimetic sensors have been designed only for the sense of smell.
Biomimetic sensors have been designed only for the sense of smell.
What does the integration of interdigitated electrodes with OBPs in electric sensors help achieve?
What does the integration of interdigitated electrodes with OBPs in electric sensors help achieve?
What characteristic is NOT required for effective taste sensors?
What characteristic is NOT required for effective taste sensors?
Taste sensors are designed to discriminate each chemical substance individually.
Taste sensors are designed to discriminate each chemical substance individually.
Name one type of biomimetic gustation sensor.
Name one type of biomimetic gustation sensor.
A taste sensor using lipid/polymer membranes relies on the concept of __________ selectivity.
A taste sensor using lipid/polymer membranes relies on the concept of __________ selectivity.
Match the following types of gustation sensors with their distinct features:
Match the following types of gustation sensors with their distinct features:
Which of the following substances are often analyzed by taste sensors?
Which of the following substances are often analyzed by taste sensors?
Global selectivity in taste sensors allows for precise identification of each chemical substance present.
Global selectivity in taste sensors allows for precise identification of each chemical substance present.
What is the main advantage of using lipid membranes in taste sensors?
What is the main advantage of using lipid membranes in taste sensors?
Flashcards
Balance Mechanism
Balance Mechanism
Balance is maintained through a complex interplay of sensory input from the inner ear, eyes, and proprioceptors. This information is processed by the brain to regulate posture and movement.
Biomimetic Balance Sensors
Biomimetic Balance Sensors
Biomimetic balance sensors are inspired by the biological structures and mechanisms of the inner ear. They aim to replicate the sensitivity and functionality of the vestibular system.
Vestibular System
Vestibular System
The vestibular system, located in the inner ear, plays a crucial role in balance. It comprises three semicircular canals and two otolith organs that detect head rotation and linear acceleration.
Olfaction
Olfaction
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Bioinspired Olfaction Sensors
Bioinspired Olfaction Sensors
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Gustation
Gustation
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Biomimetic Gustation Sensors
Biomimetic Gustation Sensors
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Olfactory Receptor Cells
Olfactory Receptor Cells
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Combinatorial Code in Olfaction
Combinatorial Code in Olfaction
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Odor Pictures in the Olfactory Bulb
Odor Pictures in the Olfactory Bulb
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Olfactory Receptor - Odorant Interaction
Olfactory Receptor - Odorant Interaction
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Multimodal Integration in Olfaction
Multimodal Integration in Olfaction
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Specific Anosmia
Specific Anosmia
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Redundancy of Olfactory Receptors
Redundancy of Olfactory Receptors
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Phylogenetic Tree of Olfactory Receptors
Phylogenetic Tree of Olfactory Receptors
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Olfactory Perception
Olfactory Perception
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Metal Oxide Gas Sensors
Metal Oxide Gas Sensors
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Conducting Polymer Gas Sensors
Conducting Polymer Gas Sensors
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Olfactory Receptor Gas Sensors
Olfactory Receptor Gas Sensors
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Odorant Binding Protein (OBP) Gas Sensors
Odorant Binding Protein (OBP) Gas Sensors
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Signal Transduction in Artificial Noses
Signal Transduction in Artificial Noses
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Artificial Noses
Artificial Noses
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Applications of Artificial Noses
Applications of Artificial Noses
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Challenges in Artificial Nose Development
Challenges in Artificial Nose Development
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Quantum Biomimetic Electronic Nose Sensor
Quantum Biomimetic Electronic Nose Sensor
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Taste Buds
Taste Buds
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Taste Transduction
Taste Transduction
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Basic Tastes
Basic Tastes
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Taste Recognition and Analysis
Taste Recognition and Analysis
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Nonselective Response of Nerve Fibers
Nonselective Response of Nerve Fibers
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Piezoelectric Quartz Crystal Sensing
Piezoelectric Quartz Crystal Sensing
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Surface Acoustic Wave (SAW) Sensing
Surface Acoustic Wave (SAW) Sensing
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Optical Sensors
Optical Sensors
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Surface Plasmon Resonance (SPR) Sensing
Surface Plasmon Resonance (SPR) Sensing
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Electric Sensors
Electric Sensors
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Biomimetic Olfactory Sensors
Biomimetic Olfactory Sensors
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In Vivo Biosensing
In Vivo Biosensing
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Vibration-Based Odor Classification
Vibration-Based Odor Classification
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Biomimetic Sensor
Biomimetic Sensor
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Challenges with Chemical Senses
Challenges with Chemical Senses
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Biomimetic Smell Sensor
Biomimetic Smell Sensor
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How a Biomimetic Smell Sensor Works
How a Biomimetic Smell Sensor Works
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Taste Sensors (briefly)
Taste Sensors (briefly)
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Taste Sensors (briefly)
Taste Sensors (briefly)
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Taste Sensor: Microfluidic System
Taste Sensor: Microfluidic System
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Taste Sensor: Biochip
Taste Sensor: Biochip
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Olfactory Code
Olfactory Code
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Olfactory Threshold
Olfactory Threshold
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Gas Sensors
Gas Sensors
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Pattern Recognition Software
Pattern Recognition Software
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Combinatorial Coding
Combinatorial Coding
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Sensitivity in Artificial Noses
Sensitivity in Artificial Noses
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Stereochemical Discrimination
Stereochemical Discrimination
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Number of Sensing Elements
Number of Sensing Elements
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Metal Oxide Gas Sensors: What are they?
Metal Oxide Gas Sensors: What are they?
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Conducting Polymer Gas Sensors: How are they different?
Conducting Polymer Gas Sensors: How are they different?
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Olfactory Receptor Gas Sensors: What do they mimic?
Olfactory Receptor Gas Sensors: What do they mimic?
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Odorant Binding Proteins: What are they?
Odorant Binding Proteins: What are they?
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What is an Artificial Nose?
What is an Artificial Nose?
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How do Artificial Noses Work?
How do Artificial Noses Work?
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What are some uses of Artificial Noses?
What are some uses of Artificial Noses?
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What are some challenges in Artificial Nose development?
What are some challenges in Artificial Nose development?
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Chemical Senses
Chemical Senses
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Global Selectivity
Global Selectivity
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Lipid Membrane Taste Sensor
Lipid Membrane Taste Sensor
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Multichannel Taste Sensor
Multichannel Taste Sensor
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Voltammetric Taste Sensor
Voltammetric Taste Sensor
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Potentiometric Taste Sensor
Potentiometric Taste Sensor
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Tissue-Based Gustation Biosensor
Tissue-Based Gustation Biosensor
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Cell-Based Gustation Biosensor
Cell-Based Gustation Biosensor
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Light-Addressable Potentiometric Sensor (LAPS)
Light-Addressable Potentiometric Sensor (LAPS)
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What is a biomimetic sensor?
What is a biomimetic sensor?
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What are the challenges with chemical senses?
What are the challenges with chemical senses?
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How does a biomimetic smell sensor work?
How does a biomimetic smell sensor work?
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Explain how a biomimetic smell sensor works in detail.
Explain how a biomimetic smell sensor works in detail.
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What are taste sensors?
What are taste sensors?
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How are taste sensors made?
How are taste sensors made?
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Describe one type of taste sensor
Describe one type of taste sensor
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Describe another type of taste sensor.
Describe another type of taste sensor.
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Study Notes
Pázmány Péter Catholic University
- Information Technology and Bionics Faculty is mentioned
Bioinspired Sensors: Balance, Olfaction and Gustation
- Lecture 7, November 13, 2024
- Presented by Dr. Sándor Földi
- Focuses on sensor technologies and biological sensing
Contents
- Physiology of balance, biomimetic balance sensors, Physiology of olfaction, Bioinspired olfaction sensor technologies, Gustation physiology, Biomimetic gustation sensors
Recap - Balance
- Includes diagrams of the Crista ampullaris and Macula
- Discusses the role of the semicircular canals, utricle, and saccule in balance
- Mentions the structures of kinocilium, stereocilia, ampullae, utricle, maculae, statoconia, and filaments in the inner ear
Artificial Vestibular System
- Based on MEMS technology and 3D printing
- Uses MEMS technology for flow/pressure sensing
- Mimics the structure of biological semicircular canals
- Includes a prototype of a biomimiced lateral semicircular canal (diagrams)
- Discusses testing of the biomimiced lateral semicircular canal (diagram showing testing procedure)
- Referenced paper: Development of a biomimetic semicircular canal with MEMS sensors to restore balance, 2019
Recap - Olfaction Mechanism
- Diagram of the olfactory mechanism
- Shows different parts like mitral cells, glomeruli, receptors, and ORNs involved
- Relates to axon guidance and map formation within the olfactory bulb
- Referenced paper: Map formation in the olfactory bulb by axon guidance of olfactory neurons, 2011
Olfaction - Biology vs. Artificial
- Explains the biological processes of olfaction (receptors, olfactory bulb, neurons, chemosensation, signal processing, pattern recognition)
- Describes how an artificial nose (electronic nose) mimics these functions (sensor array, signal processing, processor)
- Shows a diagram comparing biological and artificial olfaction
- Referenced paper: Combining two selection principles: Sensor arrays based on both biomimetic recognition and chemometrics, 2018
Olfaction
- Human olfactory system has 300 receptors
- Responds to thousands of environment molecules with millions of possible combinations
- Uses combinatorial code to distinguish between millions of odors with few hundred sensors
- Receptors are sensitive to different levels of chemicals
- Each odorant can stimulate multiple receptors
- Compares olfaction to vision and hearing
Olfaction (Processing Level)
- The responses of 300 receptors in the olfactory bulbs generate unique odor pictures that can be visualized with fluorescent dyes and imaging systems
- The pictures are processed in the brain and integrated with other sensory inputs and past memories
- Taste produces a sensation expressed through verbal descriptions, behaviors, and emotions
- The olfactory code is similar to a color code; it is a list of elementary odors which can be combined to reproduce innumerable sensations
Olfaction (Additional Details)
- 50 human olfactory receptors have been deorphanized
- Receptor redundancy ensures that important odors can still be detected even if some receptors are mutated
- Specific anosmia (inability to detect certain odors) is linked to the absence or malfunction of olfactory receptors
Olfaction (Phylogenetic Tree)
- Discusses the phylogenetic tree of 50 human deorphanized receptors (diagram included)
- Emphasizes the difficulty in replicating the exceptional sensitivity of biological noses in artificial ones
- Referenced paper: From gas sensors to biomimetic artificial noses, 2018
Olfaction (Olfactory Threshold)
- Explains the olfactory threshold - the minimum concentration detectable by an individual
- Biological olfaction is much more sensitive to odors compared to electronic instruments
Artificial Nose
- Three steps to translate chemical information into measurable odor quality and concentration parameters (diagram)
- Uses an array of gas sensors interacting with volatile molecules (electrical, optical)
- Employs amplifiers for low concentration odor detection
- Includes software for recognizing specific response profiles to different odors
- Referenced paper: Engineered biomimicry, 2013
Artificial Nose - Signal Detection
- Aim is discrimination among different molecules and sensors should discriminate based on size/shape
- Sensors use stereochemical parameters to distinguish odors
- Mammals have hundreds, Humans have approximately 300 olfactory receptors
- Compares to the information encoding in vision and hearing (color vision compared to 3 types of rhodopsins example).
- Referenced paper: Engineered biomimicry, 2013
Artificial Nose - Features of Biological and Artificial Nose
- Compares the type of sensing elements, number of sensing elements, and coding strategy in biological and artificial noses
- Referenced paper: Engineered biomimicry, 2013
Types of Gas Sensors
- Metal oxides (most frequently used, measure electrical resistance), including zinc, tin, nickel, and transition metals
- Graphene-based materials
- Problems with limited selectivity, Slow regeneration time, and high heating temperatures
- Uses in smoke alarms and cooking gas leak detection
- Conducting polymers, including improved selectivity and possibility for response modification
- Olfactory receptors (ideal for mimicking human nose but unstable and difficult to regenerate)
- Soluble binding proteins (OBPs): simple structures, high stability, binding cavity for odorant/pheromone molecules suitable for bacteria production and exceptional stability
Artificial Nose – Transducing Strategies
- Different methods (metal oxides, soluble proteins) with their conversion categories (changes in mass, optical signals, electric properties)
Artificial Nose – Transducing Strategies (Changes of Mass)
- Measures mass changes using piezoelectric quartz crystals to monitor protein oscillations.
- Uses Surface Acoustic Wave (SAW) technology to detect changes in frequency resulting from lignad binding and increasing protein sensor mass
- Includes surface plasmon resonance (SPR) with detection limits in micromolar range and related limitations
- Referenced paper: Biomimetic olfactory sensors, 2012
Artificial Nose – Transducing Strategies (Optical Sensors)
- Records changes in refractive index (refractive index) consequent to ligand binding
- Uses Surface Plasmon Resonance (SPR) technique with olfactory receptor immobilization on a prism
- Limitations in detection limits for certain small organic compounds
- Referenced paper: Biomimetic olfactory sensors, 2012
Artificial Nose – Transducing Strategies (Electric Sensors)
- Uses modified field-effect transistors (FETs) with OBPs attached to the gate electrode
- Measures changes in current produced in the presence of various ligands (with change in impedance)
- This approach can build biosensors to detect changes in impedance produced when ligands present in the medium
- Referenced paper: Biomimetic olfactory sensors, 2012
Artificial Nose – Examples (In vivo biosensing)
- Diagrams illustrates the in vivo biosensing approach with odor interaction, signal generation, pattern recognition
- Includes detection and discrimination for diverse odor classes.
- Referenced paper: Biomimetic sensors for the senses, 2017
Artificial Nose – Examples (Vibration-based Odorification)
- Discusses vibration-based odor classification inspired by the vibration theory of biological olfaction
- Explains eigen-value vibrational pseudo spectra analysis combined with unsupervised machine learning algorithms like spectral clustering
- Shows diagram illustrating shape and vibration theory, class identification and human perception-based classification for distinct odor classes
- Referenced paper: Vibration-based biomimetic odor classification, 2021
Artificial Nose – Examples (Quantum Biomimetic Electronic Nose Sensor)
- Discusses quantum biomimetic Electronic Nose Sensor with diagrams demonstrating the different structural aspects of this model
- Shows how the model mimics the vibration theory of biological olfaction, while employing photon-assisted inelastic electron tunneling spectroscopy.
- Referenced paper: A quantum biomimetic electronic nose sensor, 2018
Recap – Gustation
- Shows diagrams about sweet/sour/bitter/salty/umami receptors and their interactions in the tongue
Gustation – Physiology
- Details on the structure and function of taste buds, taste receptor cells (50-100 in each taste bud) in response to various substances
- Describes the central role of the brain (recognition of patterns) in differentiating, classifying and analyzing the detected substances and inducing sensation
... (rest of the notes remain the same)
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Description
Test your knowledge on biomimetic technology, specifically in the context of artificial vestibular systems and odor detection. This quiz covers various components, mechanisms, and functions related to biomimetic sensors and their applications in balance and smell. Challenge yourself with matching exercises and research-based questions.