Biology Chapter: The Cell

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Questions and Answers

Who first observed cells and named them in 1665?

  • Theodor Schwann
  • Rudolf Virchow
  • Robert Hooke (correct)
  • Matthias Schleiden

What principle did Rudolf Virchow introduce to the Cell Theory in 1855?

  • Every cell arises from a pre-existing one. (correct)
  • The cell is the basic unit of life.
  • Cells are the smallest units of matter.
  • All living organisms are made up of cells.

What percentage of a cell's composition is water?

  • 70% (correct)
  • 80%
  • 50%
  • 60%

Which of the following is NOT a key element that cells are composed of?

<p>Boron (A)</p> Signup and view all the answers

What is the primary function of the plasma membrane in a cell?

<p>To regulate movement of substances in and out. (C)</p> Signup and view all the answers

Which of the following statements is part of the Cell Theory?

<p>All living organisms are composed of one or more cells. (C)</p> Signup and view all the answers

What component of the cell provides a medium for metabolic reactions?

<p>Cytoplasm (C)</p> Signup and view all the answers

Which of the following is NOT a characteristic shared by all cells?

<p>Possession of a nucleus (C)</p> Signup and view all the answers

What is the primary role of ATP in the cell?

<p>Acting as an energy currency. (A)</p> Signup and view all the answers

Which of the following defines the function of NAD and NADP?

<p>Serving as electron carriers in redox reactions. (D)</p> Signup and view all the answers

What is Acetyl-CoA mainly involved in?

<p>Linking carbohydrate, fat, and protein metabolism. (A)</p> Signup and view all the answers

What triggers the release of energy from ATP?

<p>The breaking of the bond with the terminal phosphate group. (B)</p> Signup and view all the answers

What is vesicular trafficking primarily responsible for?

<p>Transporting molecules within the cell. (D)</p> Signup and view all the answers

Which molecule is involved in the citric acid cycle to extract energy?

<p>FAD. (A)</p> Signup and view all the answers

Which component is essential for membrane trafficking?

<p>Vesicles and organelle contact points. (B)</p> Signup and view all the answers

How do NAD and NADP molecules alternate during metabolic reactions?

<p>Between oxidized and reduced states. (D)</p> Signup and view all the answers

What do sugars combine to form, which provides energy and structural support?

<p>Polysaccharides (B)</p> Signup and view all the answers

Which process involves the removal of water to form covalent bonds between monomers?

<p>Condensation reactions (C)</p> Signup and view all the answers

What is the typical size range for most eukaryotic cells?

<p>10--100 microns (D)</p> Signup and view all the answers

What factor is crucial for the efficiency of nutrient exchange in cells?

<p>Surface-to-volume ratio (D)</p> Signup and view all the answers

What are activated carrier molecules responsible for in a cell?

<p>Storing and transporting energy (D)</p> Signup and view all the answers

Which of the following is NOT an example of an activated carrier molecule?

<p>Cellulose (D)</p> Signup and view all the answers

How does cell size affect metabolism when a cell grows larger?

<p>Increases metabolic demands (B), Decreases surface area proportion (C)</p> Signup and view all the answers

What role do cell-cell junctions play in multicellular structures?

<p>Enhance intercellular communication (D)</p> Signup and view all the answers

What is primarily responsible for the selective barrier function of the plasma membrane?

<p>Phospholipid bilayer (C)</p> Signup and view all the answers

Which component of the plasma membrane is crucial for maintaining its fluidity?

<p>Cholesterol (B)</p> Signup and view all the answers

What does membrane asymmetry allow for in a cell?

<p>Distinct chemical environments (D)</p> Signup and view all the answers

How do most ions and larger molecules cross the plasma membrane?

<p>Facilitated by transport proteins (C)</p> Signup and view all the answers

What establishes the directional organization of the plasma membrane during vesicle fusion?

<p>Membrane polarity (C)</p> Signup and view all the answers

Which lipids are more abundant in the extracellular leaflet of the plasma membrane?

<p>Phosphatidylcholine (C)</p> Signup and view all the answers

What is a critical role of cholesterol in the plasma membrane?

<p>Enhancing rigidity (B)</p> Signup and view all the answers

What is one of the essential functions of the plasma membrane?

<p>Facilitating communication with surroundings (A)</p> Signup and view all the answers

What role do vesicles play in hormone secretion?

<p>They transport hormones from the Golgi apparatus to the plasma membrane. (A)</p> Signup and view all the answers

Which type of proteins assist vesicles in moving along the cytoskeleton?

<p>Kinesins and dyneins (C)</p> Signup and view all the answers

How does compartmentalization of organelles benefit cellular processes?

<p>By isolating specific processes and maintaining distinct environments. (B)</p> Signup and view all the answers

What is the significance of contact points in cellular trafficking?

<p>They provide regions for direct exchange of molecules. (C)</p> Signup and view all the answers

What does the dynamic nature of cellular processes reveal about traditional textbook representations?

<p>They often fail to capture the rapid and coordinated cellular events. (C)</p> Signup and view all the answers

In neurons, what process is facilitated by vesicles containing neurotransmitters?

<p>They enable communication between neurons at the synapse. (A)</p> Signup and view all the answers

Which organelle is specifically mentioned as having an acidic environment for breaking down macromolecules?

<p>Lysosomes (D)</p> Signup and view all the answers

What is the overall purpose of vesicular trafficking in multicellular organisms?

<p>To maintain internal cellular organization and support extracellular processes. (A)</p> Signup and view all the answers

What is the primary function of the nucleus in a cell?

<p>To regulate gene expression and house DNA (A)</p> Signup and view all the answers

What structure encloses the nucleus?

<p>Nuclear envelope (D)</p> Signup and view all the answers

Why are nuclear pores important?

<p>They allow selective transport of macromolecules (D)</p> Signup and view all the answers

What role does the nucleolus play within the nucleus?

<p>It assembles ribosomes and produces rRNA (A)</p> Signup and view all the answers

What happens to chromatin during DNA transcription?

<p>Chromatin becomes less condensed (C)</p> Signup and view all the answers

Which of the following best describes the dynamic nature of the nucleus?

<p>The nucleus changes based on the cell's metabolic state (D)</p> Signup and view all the answers

What typically influences the number of nucleoli within a cell?

<p>The specific metabolic needs of the cell (D)</p> Signup and view all the answers

What is the diameter of the nucleus, on average?

<p>5 micrometers (µm) (C)</p> Signup and view all the answers

Flashcards

Cell

The smallest and most fundamental unit of life, responsible for all biological processes.

Cell Theory

The concept that all living organisms are composed of cells, cells are the basic unit of life, and new cells arise from pre-existing cells.

Robert Hooke

A scientist who observed plant tissue under a microscope and named the small, chamber-like structures "cells", laying the groundwork for the Cell Theory.

Matthias Schleiden and Theodor Schwann

Scientists who formally proposed the Cell Theory, stating that all living organisms are made up of cells and the cell is the basic unit of life.

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"Omnis cellula e cellula"

The principle that all cells arise from pre-existing cells, expanding on Cell Theory.

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Plasma membrane

The outer boundary of a cell that separates the cell's internal environment from its surroundings.

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Cytoplasm

The gel-like substance within a cell that provides a medium for metabolic reactions.

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Nucleus

The central organelle in eukaryotic cells that contains the genetic material.

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Macromolecules

Complex molecules made up of repeating subunits called monomers.

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Monosaccharides

Sugars that combine to form polysaccharides, serving as energy sources and structural components.

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Fatty acids

The building blocks of lipids, essential for cell membranes and long-term energy storage.

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Amino acids

Components of proteins, responsible for various functions like catalyzing reactions and transporting molecules.

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Nucleotides

Monomers of nucleic acids like DNA and RNA, responsible for storing and transmitting genetic information.

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Condensation reaction

A chemical reaction that removes water to form covalent bonds between monomers, creating macromolecules.

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Hydrolysis

A chemical reaction that uses water to break covalent bonds between monomers, releasing energy.

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Activated carrier molecules

Molecules that store chemical-bond energy in a readily usable form, powering cellular processes.

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What is ATP?

A molecule that carries energy within cells, breaking down into ADP and releasing energy for processes like active transport, cell movement, and molecule synthesis.

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What are NAD/NADP?

A central carrier molecule for electrons, switching between oxidized (NAD⁺/NADP⁺) and reduced (NADH/NADPH) states in metabolic reactions. Helps with electron transfer for energy production.

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What is FAD?

Works like NAD/NADP, crucial for the citric acid cycle, capturing electrons and helping extract energy from organic molecules.

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What is Acetyl-CoA?

A key metabolic molecule connecting carbohydrate, fat, and protein metabolism, delivering acetyl groups to the citric acid cycle for energy production.

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What is membrane trafficking?

The movement of materials within cells, essential for maintaining cell organization and function; it involves two major components: vesicular trafficking and organelle contact points.

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What are vesicles?

Small, membrane-bound carriers that transport molecules between cellular compartments, acting as vehicles for cargo, but not performing chemical reactions themselves.

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What is vesicular trafficking?

The process of moving molecules between organelles and the plasma membrane using vesicles.

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What are organelle contact points?

Sites where different organelles come together to exchange molecules or signals, facilitating communication and coordinated function within the cell.

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Vesicular Trafficking

The movement of membrane-bound sacs (vesicles) within a cell. This process is crucial for maintaining proper cell organization and carrying out various functions.

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Organelles

Specialized compartments within eukaryotic cells that have unique functions and environments. Examples include lysosomes, mitochondria, and the Golgi apparatus.

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Organelle Compartmentalization

The process of keeping organelles separate within a cell, maintaining optimal environments for specific reactions and processes.

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Cytoskeleton

A network of protein filaments that give structure to the cell and act as 'rails' for moving vesicles and organelles.

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Motor Proteins (e.g., Kinesins and Dyneins)

Motor proteins that 'walk' along microtubules in the cytoskeleton, transporting vesicles to specific destinations.

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Contact Points

Regions where membranes from different organelles come very close, allowing for direct exchange of molecules.

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Real-Time Cellular Imaging

The process of using microscopic techniques to observe live cells in action, revealing the dynamic nature of cellular processes.

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Limitations of Fixed Cells

Traditional images of organelles in textbooks often fail to capture the dynamism of cellular processes. This is because those images come from cells that were preserved (fixed) for observation.

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What is the nucleus?

The nucleus is the control center of the cell, housing the genetic material (DNA) and regulating gene expression.

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What is the nuclear envelope?

The nuclear envelope is a double membrane that surrounds the nucleus, separating it from the cytoplasm.

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What are nuclear pores?

Nuclear pores are tiny openings in the nuclear envelope that control the movement of molecules in and out of the nucleus.

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What is the nucleolus?

The nucleolus is a dense region within the nucleus responsible for producing ribosomal RNA (rRNA) and assembling ribosomes.

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What molecules move through nuclear pores?

mRNA, ribosomal subunits, and enzymes are examples of molecules that move through nuclear pores.

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Is the nucleus static or dynamic?

The nucleus is dynamic, changing its organization and activity based on the cell's needs.

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How does chromatin change during transcription?

During DNA transcription, chromatin becomes less condensed, allowing access to the genetic material.

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Why is the nucleus important?

The nucleus is essential for cell function, controlling gene expression and regulating cellular processes.

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Phospholipid Bilayer

A type of lipid with a hydrophilic head and a hydrophobic tail. Two layers of phospholipids form the basis of the plasma membrane.

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Membrane Asymmetry

The property of the plasma membrane where the inside and outside layers have different compositions and functions.

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Membrane Polarity

The property of the plasma membrane where its structure is organized in a specific direction during processes like vesicle budding and fusion.

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Passive Transport

The movement of molecules across the plasma membrane without the need for energy or transport proteins.

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Active Transport

The movement of molecules across the plasma membrane that requires energy and transport proteins.

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Endocytosis

The process by which cells take in substances from their surrounding environment, forming small membrane-bound packages called vesicles.

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Exocytosis

The process by which cells release substances from their interior into the surrounding environment using membrane-bound vesicles.

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Study Notes

The Cell: The Fundamental Unit of Life

  • Cells are the basic units of all living organisms
  • Responsible for all life processes including growth, reproduction, and function
  • First recognized by Robert Hooke in 1665
  • Cell Theory, proposed by Matthias Schleiden and Theodor Schwann (1838-39), states all living organisms are composed of cells, the cell is the basic unit of life, and new cells arise only from pre-existing cells
  • Cell Theory expanded in 1855 by Rudolf Virchow with the principle “omnis cellula e cellula” – every cell arises from a pre-existing cell

Universal Features of Cells

  • All cells share common characteristics
  • Plasma membrane: boundary between interior and exterior
  • Cytoplasm: medium for metabolic reactions
  • Nucleus (eukaryotic cells): Houses genetic material
  • Cells are primarily composed of water (~70%) and six key elements (H, C, O, N, S, P)

Macromolecule Composition

  • Sugars: form polysaccharides, provide energy and structure
  • Fatty acids: form lipids, for cell membranes and energy storage
  • Amino acids: form proteins, with diverse functions (catalysing reactions, transporting molecules)
  • Nucleotides: form nucleic acids (DNA, RNA), store and transmit genetic information

Understanding Cell Size and Limitations

  • Eukaryotic cells: 10-100 microns
  • Prokaryotic cells (bacteria): 1-50 microns
  • Small size is crucial for efficient exchange of nutrients, gases, and waste with the environment
  • Surface-to-volume ratio impacts a cell's ability to sustain itself as it grows.

Energy and Cellular Processes

  • Cells need energy for essential functions (movement, synthesis, maintaining stability)
  • Stored in activated carrier molecules (ATP, NAD, NADP, FAD, Acetyl-CoA)
  • Easily exchangeable and transportable, powering a wide range of cellular processes.

Activated Carrier Molecules

  • ATP: the primary energy currency, releases energy when bonds are broken. Fuels active transport, cell motility and synthesis of macromolecules like DNA and proteins.
  • NAD/NADP: Electron carriers, alternate between oxidized (NAD+/NADP+) and reduced (NADH/NADPH) states, critical for redox reactions, transferring electrons for energy production.
  • FAD: Similar electron carrier function to NAD and NADP. Key in the citric acid cycle, extracting energy from organic molecules.
  • Acetyl-CoA: Central metabolic intermediate, links carbohydrate, fat, and protein metabolism.

Membrane Trafficking

  • Movement of materials within cells (between organelles and plasma membrane)
  • Vesicular Trafficking: Small membrane-bound carriers transport molecules between compartments
  • Organelle Trafficking and Compartmentalization: Specific organelles (like lysosomes) isolate reactions to maintain proper cellular functions

The Plasma Membrane: Structure and Function

  • Defines the cell boundary, regulates molecule transport, and facilitates communication
  • Primarily composed of a phospholipid bilayer with embedded proteins, cholesterol, and other lipids.
  • Amphipathic nature (hydrophilic heads, hydrophobic tails) creates a selective barrier.
  • Regulates movement of molecules in and out of the cell
  • Plays roles in cell signaling and communication, intercellular adhesion, and maintaining intracellular/extracellular environments.

The Plasma Membrane: Asymmetry and Polarity

  • Asymmetry: uneven distribution of phospholipids across the inner and outer layers. Essential to biological processes
  • Polarity: Membrane layers display distinct directional organization, vital for processes like secretion and endocytosis.

Membrane Proteins and Lipid Modifications

  • Integral membrane proteins: span the bilayer; function as transporters, receptors, enzymes
  • Peripheral membrane proteins: located on membrane surface; often interact with integral proteins
  • Lipid modifications (like GPI anchoring) play roles in anchoring and localization of specific membrane proteins in precise locations.

Cytoskeleton: Structure and Function

  • Dynamic network of protein filaments that provides structural support and facilitates intracellular transport and cell movement.
  • Intermediate Filaments: Strong, rope-like components providing structural strength
  • Microtubules: Hollow tubes involved in cell shape, movement, intracellular transport; grow and shrink regularly; originate from the centrosome
  • Actin filaments: Thinnest; involved in processes like cell shape, movement, and intracellular transport

The Endoplasmic Reticulum (ER)

  • Extensive network of membranes and sacs called cisternae; continuous with the nuclear envelope.
  • Rough ER: Studded with ribosomes; site of protein synthesis and modification (e.g., glycosylation)
  • Smooth ER: Lacks ribosomes; involved in lipid synthesis, detoxification of harmful substances, and calcium storage.

Mitochondria

  • "Powerhouses of the cell"; responsible for ATP generation via oxidative phosphorylation.
  • Double membrane system (outer and inner); inner membrane highly folded into cristae to maximize surface area for protein complexes.
  • Site of the Krebs (citric acid) cycle, generating electron carriers (NADH, FADH2) that drive ATP production in the electron transport chain.

Nucleus: The Control Center

  • The cell's control center, containing genetic material (DNA)
  • Separates genetic material from cytoplasm
  • Encloses DNA; site of transcription (DNA to RNA)
  • Nuclear envelope: double membrane with nuclear pores allowing specific molecules to pass through

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