COPY: Lecture 3
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Questions and Answers

What term describes the process by which organisms maintain a relatively stable internal environment?

  • Equilibrium
  • Homeostasis (correct)
  • Diffusion
  • Osmosis

Which of the following is NOT a key concept associated with homeostasis?

  • Intracellular fluid (ICF)
  • Dynamic steady state
  • Absolute equilibrium (correct)
  • Extracellular fluid (ECF)

In multicellular organisms, what is essential for maintaining homeostasis at the cellular level?

  • Unregulated cell growth
  • Cellular isolation
  • Random cell migration
  • Intercellular communication (correct)

Which of the following represents the primary role of intercellular communication?

<p>Enabling cell survival, division, differentiation, and death (A)</p> Signup and view all the answers

What are the two basic types of signals cells use for intercellular communication?

<p>Electrical and Chemical (A)</p> Signup and view all the answers

What happens if an organism's compensatory mechanism is NOT successful when homeostasis is disrupted?

<p>Homeostasis is further disrupted, possibly leading to disease (C)</p> Signup and view all the answers

Which term describes cells that respond to either electrical or chemical signals?

<p>Target cells (C)</p> Signup and view all the answers

What is the extracellular fluid (ECF)'s function in relation to homeostasis?

<p>To serve as a link between cells and the external environment (B)</p> Signup and view all the answers

What is the immediate effect of a ligand binding to a cell-surface receptor?

<p>Change in receptor conformation (A)</p> Signup and view all the answers

Which factor primarily determines the type of ion channel that will be activated?

<p>The type of stimuli present (D)</p> Signup and view all the answers

What property defines the 'selectivity' of an ion channel?

<p>The specific types of ions it allows to pass through (A)</p> Signup and view all the answers

What is the primary function of protein kinases?

<p>To phosphorylate specific proteins. (C)</p> Signup and view all the answers

A voltage-gated ion channel is least likely to be open when:

<p>The cell membrane is polarized. (A)</p> Signup and view all the answers

What is the primary function of ligand-gated ion channels in neural communication?

<p>To convert chemical signals into electrical signals (D)</p> Signup and view all the answers

Which subunit of a G protein is most crucial for determining the specificity of signal transduction?

<p>The alpha (α) subunit (D)</p> Signup and view all the answers

In the inactive state of a G protein, which molecule is bound to the alpha (α) subunit?

<p>GDP (B)</p> Signup and view all the answers

Which of the following is NOT a typical outcome of ion channel activation following neurotransmitter binding?

<p>Increased synthesis of neurotransmitter molecules. (D)</p> Signup and view all the answers

What two molecules are created after the activation of a G protein when GTP replaces GDP??

<p>The α-subunit linked to GTP and the βγ complex. (B)</p> Signup and view all the answers

How do G protein-coupled receptors (GPCRs) generally differ from ion channel-coupled receptors in their signaling action?

<p>GPCRs transmit signals through secondary signaling molecules. (D)</p> Signup and view all the answers

Which of the following is NOT a typical target of G proteins?

<p>Protein kinase (B)</p> Signup and view all the answers

What is an important characteristic of an ion channel in its role as a cell receptor?

<p>Fast response to stimuli. (D)</p> Signup and view all the answers

What is the second messenger molecule formed by adenylyl cyclase?

<p>cAMP (B)</p> Signup and view all the answers

Which of these ligands can cause the activation of adenylyl cyclase?

<p>Glucagon (D)</p> Signup and view all the answers

What two molecules are produced by the activation of phospholipase C?

<p>IP3 and DAG (C)</p> Signup and view all the answers

Which of the following is NOT a characteristic of ligands that bind to intracellular receptors?

<p>Large and hydrophilic (A)</p> Signup and view all the answers

In its active state, where are intracellular receptors primarily located?

<p>Nucleus (A)</p> Signup and view all the answers

What type of cellular communication involves direct contact between cells for signal transfer?

<p>Juxtacrine (A)</p> Signup and view all the answers

Which domain of a nuclear receptor is responsible for interacting with specific DNA sequences?

<p>DNA binding domain (DBD) (A)</p> Signup and view all the answers

What is the typical length of the hormone response element (HRE) sequence?

<p>15 nucleotides (B)</p> Signup and view all the answers

Which communication method involves molecules released by a cell acting on neighboring cells through the extracellular fluid?

<p>Paracrine (D)</p> Signup and view all the answers

What term describes a nuclear receptor composed of two different protein subunits?

<p>Heterodimer (A)</p> Signup and view all the answers

In autocrine communication, where do the released molecules exert their effect?

<p>On the same cell that released them (D)</p> Signup and view all the answers

What is the primary means of signal distribution in endocrine communication?

<p>The circulatory system via the bloodstream (D)</p> Signup and view all the answers

Which of the following is NOT a family of receptors included in the intracellular receptor category?

<p>Receptors for growth factors (A)</p> Signup and view all the answers

Which of these is a characteristic associated with cell-surface receptors?

<p>Binding of large, hydrophilic or charged molecules (D)</p> Signup and view all the answers

Which system uses a combination of electrical and chemical signals to communicate over long distances?

<p>The nervous system (D)</p> Signup and view all the answers

How do neurotransmitters differ from neurohormones in their mode of action?

<p>Neurotransmitters have a fast, localized effect by diffusing across the synaptic cleft, while neurohormones travel through the bloodstream for a slower effect. (C)</p> Signup and view all the answers

How do ion channel-linked receptors affect the cell membrane?

<p>They cause a change in membrane potential and permeability to specific ions (D)</p> Signup and view all the answers

In neuronal communication, what type of signal is converted into a chemical signal at the end of the neuron?

<p>Electrical signal (D)</p> Signup and view all the answers

What is the function of cellular receptors in cell communication?

<p>To receive, transform, and transmit information from the external environment (D)</p> Signup and view all the answers

Which of the following is a characteristic of enzyme-linked receptors?

<p>Their activation typically involves multiple intracellular transduction steps. (A)</p> Signup and view all the answers

Which of the following is NOT a functional type of enzyme-linked receptor?

<p>Lipid kinase (A)</p> Signup and view all the answers

What process directly follows the binding of a ligand to a tyrosine kinase receptor?

<p>Formation of a receptor dimer. (B)</p> Signup and view all the answers

What is the role of tyrosine residues in the activation of tyrosine kinases?

<p>They are involved in mutual phosphorylation during receptor dimerization. (A)</p> Signup and view all the answers

Which of the following describes the Ras protein in its active state?

<p>Bound to GTP (C)</p> Signup and view all the answers

How is the Ras protein activated?

<p>By an adaptor protein binding a GEF protein, causing GDP to be replaced by GTP. (A)</p> Signup and view all the answers

What is the function of the phosphorylation cascade triggered by activated Ras?

<p>To amplify the signal through phosphorylation of downstream kinases. (D)</p> Signup and view all the answers

What is the role of MAP kinase in the signaling cascade?

<p>It phosphorylates target proteins to produce a cellular response. (B)</p> Signup and view all the answers

Which type of communication requires direct cell-to-cell contact?

<p>Juxtacrine communication (A)</p> Signup and view all the answers

In which type of communication do signaling molecules act on the same cell that released them?

<p>Autocrine communication (C)</p> Signup and view all the answers

What characterizes endocrine communication?

<p>Signaling molecules are transported via the bloodstream (D)</p> Signup and view all the answers

Which type of molecule does neuronal communication primarily utilize?

<p>Neurotransmitters and neurohormones (A)</p> Signup and view all the answers

What defines paracrine communication?

<p>It affects only neighboring cells through the extracellular fluid. (A)</p> Signup and view all the answers

What is the primary effect of neurotransmitters in synaptic communication?

<p>To diffuse across the synaptic cleft rapidly (C)</p> Signup and view all the answers

In which type of communication do signaling molecules travel long distances through the circulatory system?

<p>Endocrine communication (C)</p> Signup and view all the answers

Which cells are primarily affected by hormones in endocrine communication?

<p>Specific target cells with appropriate receptors (D)</p> Signup and view all the answers

What is a characteristic feature of enzyme-linked receptors?

<p>They have effects that may require multiple intracellular transduction steps. (A)</p> Signup and view all the answers

What is the first stage in the action of tyrosine kinases?

<p>Binding of signaling proteins to the receptor. (A)</p> Signup and view all the answers

What characteristic of a signaling molecule determines whether it can pass through the cell membrane?

<p>Hydrophobicity (D)</p> Signup and view all the answers

What is NOT a potential consequence of ligand binding to a receptor?

<p>Day-night cycle change (D)</p> Signup and view all the answers

How does the Ras protein become activated?

<p>By converting GDP to GTP via a GEF protein. (A)</p> Signup and view all the answers

Which of the following best describes the role of MAP kinase in the phosphorylation cascade?

<p>It is involved in the phosphorylation of target proteins. (A)</p> Signup and view all the answers

Which type of receptor is responsible for binding hydrophobic signaling molecules?

<p>Intracellular receptors (C)</p> Signup and view all the answers

In which way can a single signaling molecule affect different target cells?

<p>Different receptors on different cells (C)</p> Signup and view all the answers

What is a key function of tyrosine kinases?

<p>They induce a change in gene expression. (A)</p> Signup and view all the answers

Which ligands are known to activate tyrosine kinases?

<p>FGF, EGF, PDGF, and VEGF. (A)</p> Signup and view all the answers

Which of the following accurately describes antagonists in cellular signaling?

<p>They inhibit receptor activity (A)</p> Signup and view all the answers

What type of signaling molecules do NOT require the presence of a receptor on the target cell to exert their effect?

<p>Small and hydrophobic molecules (B)</p> Signup and view all the answers

What type of protein is predominantly activated by most tyrosine kinases?

<p>Ras proteins. (A)</p> Signup and view all the answers

Which category includes signaling molecules that are typically unable to cross the cell membrane?

<p>Hydrophilic signaling molecules (A)</p> Signup and view all the answers

What is the state of Ras protein when it is inactive?

<p>It is bound to GDP. (A)</p> Signup and view all the answers

Which of the following definitions correctly describes ligands in terms of their function?

<p>They act as signaling molecules that bind to receptors (C)</p> Signup and view all the answers

What occurs when homeostasis is disrupted and compensation is unsuccessful?

<p>The organism may develop a disease (B)</p> Signup and view all the answers

Which compartment serves as a link between the external environment and cells in the context of homeostasis?

<p>Extracellular fluid (ECF) (B)</p> Signup and view all the answers

How do cells communicate to maintain homeostasis in multicellular organisms?

<p>Through intercellular communication or signaling (B)</p> Signup and view all the answers

What characterizes a dynamic steady state in homeostasis?

<p>Constant movement and imbalance of substances (B)</p> Signup and view all the answers

What is the primary role of electrical signals in cell communication?

<p>To trigger changes in the cell's membrane potential (A)</p> Signup and view all the answers

Which of the following statements about intercellular signaling is true?

<p>Both electrical and chemical signals can initiate a response in target cells (D)</p> Signup and view all the answers

Which level of coordination is essential for maintaining homeostasis in multicellular organisms?

<p>Across cells, tissues, and entire systems (C)</p> Signup and view all the answers

What type of environment do cells within tissues maintain to achieve homeostasis?

<p>A relatively stable internal environment overall (B)</p> Signup and view all the answers

What role does a ligand play in the process of signal transduction?

<p>It binds to a specific receptor on the target cell membrane. (D)</p> Signup and view all the answers

How does the activation of G proteins occur?

<p>By the exchange of GDP for GTP. (D)</p> Signup and view all the answers

What describes the conformational change in 7TM receptors upon ligand binding?

<p>It induces further signaling within the cell. (C)</p> Signup and view all the answers

What mechanism is primarily responsible for the switch-like behavior of molecular switches?

<p>Phosphorylation and dephosphorylation. (C)</p> Signup and view all the answers

Which outcome is part of the signaling cascade within the cell?

<p>Activation or inactivation of an enzyme. (B)</p> Signup and view all the answers

What is the primary characteristic of G protein-coupled receptors (GPCRs)?

<p>They consist of seven transmembrane (7TM) domains. (D)</p> Signup and view all the answers

What is the role of intracellular signaling molecules in the context of a signaling cascade?

<p>They propagate the signal deeper into the cell. (C)</p> Signup and view all the answers

How do molecular switches maintain their active state?

<p>Through prolonged GTP binding. (A)</p> Signup and view all the answers

What is the primary function of intracellular receptors?

<p>Regulate gene expression (D)</p> Signup and view all the answers

Which component is NOT part of the nuclear receptor structure?

<p>Signal transducing domain (C)</p> Signup and view all the answers

What type of dimer is typically formed by most nuclear receptors?

<p>Both B and C (A)</p> Signup and view all the answers

Which of the following ligands can bind to intracellular receptors?

<p>Cortisol (A)</p> Signup and view all the answers

In which cellular location do intracellular receptors primarily function when active?

<p>Nucleus (B)</p> Signup and view all the answers

Which of these best describes the hormone response element (HRE)?

<p>A 15-nucleotide sequence within the nucleus (A)</p> Signup and view all the answers

How do cell-surface receptors differ from intracellular receptors in terms of ligand characteristics?

<p>Cell-surface receptors bind large, hydrophilic molecules (B)</p> Signup and view all the answers

Which ion would most likely pass through an opened ion channel linked to a receptor?

<p>Calcium ions (Ca2+) (C)</p> Signup and view all the answers

Intracellular receptors are divided into which of the following categories?

<p>Nuclear receptors and cytoplasmic receptors (B)</p> Signup and view all the answers

Cell surface receptors are divided into which of the following categories?

<p>All of the above (D)</p> Signup and view all the answers

Signup and view all the answers

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