Biology Chapter on Electron Transport Chain

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Questions and Answers

What is the role of complex I in the electron transport chain?

  • It reduces cytochrome c.
  • It directly synthesizes ATP from ADP.
  • It pumps protons from the intermembrane space into the matrix.
  • It hydrolyzes NADH to form NAD+ and protons. (correct)

What is produced as a byproduct in complex IV?

  • Fumarate
  • Carbon dioxide
  • Water (correct)
  • Reactive oxygen species

Which of the following describes the function of phosphocreatine?

  • It permanently alters ADP to form ATP.
  • It directly phosphorylates ADP into ATP.
  • It replaces ATP as the primary energy source.
  • It acts as a transport molecule for high-energy phosphates. (correct)

What does the proton motive force (Δp) depend on?

<p>pH gradient and membrane potential (B)</p> Signup and view all the answers

What is the main function of complex V in the electron transport chain?

<p>To synthesize ATP using the proton gradient. (D)</p> Signup and view all the answers

What happens to phosphocreatine after it donates its phosphate group?

<p>It converts into creatine and is phosphorylated again. (C)</p> Signup and view all the answers

What drives the process of ATP synthesis in the electron transport chain?

<p>The buildup of a proton gradient and the resulting energy. (C)</p> Signup and view all the answers

What is the primary function of the giant axons in earthworms?

<p>Conducting action potentials rapidly (D)</p> Signup and view all the answers

Which cells are responsible for forming the myelin sheath in the central nervous system?

<p>Oligodendrocytes (B)</p> Signup and view all the answers

What structural feature of myelinated axons allows for rapid ion exchange?

<p>Nodes of Ranvier (A)</p> Signup and view all the answers

How does myelination affect membrane resistance?

<p>Increases membrane resistance (B)</p> Signup and view all the answers

In which organism is the squid giant axon most notably studied for action potential features?

<p>Squid (D)</p> Signup and view all the answers

What is a key mechanism to prevent inefficient energy use in metabolic pathways?

<p>Reciprocal regulation (A)</p> Signup and view all the answers

Which of the following is a method for measuring metabolic rate?

<p>31P-NMR Spectroscopy (C)</p> Signup and view all the answers

What is one of the main advantages of using 31P-NMR Spectroscopy?

<p>Measures cellular energy currency (D)</p> Signup and view all the answers

What is a limitation of Direct Calorimetry?

<p>Requires the subject to be restrained (B)</p> Signup and view all the answers

According to Hess’s Law, what determines the total energy released from fuel breakdown?

<p>Given amount of fuel (A)</p> Signup and view all the answers

Which of the following nutrient types is used as a metabolic fuel?

<p>Carbohydrates (A)</p> Signup and view all the answers

What is a disadvantage of both 31P-NMR Spectroscopy and Direct Calorimetry?

<p>Require complex and heavy equipment (A)</p> Signup and view all the answers

Which of the following correctly describes a metabolic state?

<p>Energetic intermediates regulate the balance between anabolism and catabolism (A)</p> Signup and view all the answers

What does measuring ATP turnover indicate?

<p>The energy balance of the cell (C)</p> Signup and view all the answers

What occurs to the partial pressure of all gases with increased elevation?

<p>It decreases for all gases. (C)</p> Signup and view all the answers

Which adaptive physiological response occurs to compensate for lower PO2 levels at high elevations?

<p>Hyperventilation to enhance O2 exchange. (A)</p> Signup and view all the answers

What effect does lowering CO2 levels in blood have?

<p>It raises blood pH. (B)</p> Signup and view all the answers

How does the Bohr effect relate to oxygen release at tissues?

<p>It discourages oxygen release at low pH. (B)</p> Signup and view all the answers

What physiological change occurs after a few days at high elevation?

<p>Increased release of 2,3-DPG into circulation. (B)</p> Signup and view all the answers

What type of ventilation is characterized by animals propelling themselves through water to facilitate gas exchange?

<p>Ram ventilation. (B)</p> Signup and view all the answers

What anatomical feature allows mammals to create negative pressure in the lungs during inspiration?

<p>Contraction of the diaphragm. (B)</p> Signup and view all the answers

What is defined as the volume of the non-respiratory portion of the respiratory system?

<p>Anatomical dead space. (D)</p> Signup and view all the answers

What term describes the volume not involved in gas transfer, including anatomical dead space?

<p>Physiological dead space. (A)</p> Signup and view all the answers

What occurs during exhalation in mammals?

<p>Internal intercostals contract. (A)</p> Signup and view all the answers

What causes the action potential to propagate in a unidirectional manner along the neuron?

<p>The influx of sodium ions and the refractory state of upstream channels. (B)</p> Signup and view all the answers

What is the length constant in terms of neuronal signals?

<p>The distance over which the potential decays by 63%. (B)</p> Signup and view all the answers

What happens to sodium channels immediately upstream of the action potential site as the wave progresses?

<p>They are in a refractory period and cannot generate another action potential. (C)</p> Signup and view all the answers

What role does diffusion of sodium ions play in action potential propagation?

<p>It causes depolarization at the next segment of the neuron. (D)</p> Signup and view all the answers

What can affect the length constant of an axon?

<p>The quantity of myelin sheath surrounding the axon. (C)</p> Signup and view all the answers

What is the consequence of the decay of potential as one moves away from the action potential site?

<p>The ability of downstream membranes to respond decreases. (B)</p> Signup and view all the answers

Why is it important to understand the concept of the Hodgkin cycle in relation to action potentials?

<p>It outlines the feedback mechanism for channel activation during depolarization. (A)</p> Signup and view all the answers

What leads to the decrease of Vm detection away from the stimulation site?

<p>Passive movement of charge potential diminishes over distance. (A)</p> Signup and view all the answers

What is the characteristic behavior of Na channels during an action potential wave?

<p>They experience rapid closure followed by sequential opening. (A)</p> Signup and view all the answers

Flashcards

Proton Motive Force (𝚫p)

The difference in proton concentration and electrical potential across the inner mitochondrial membrane.

F1F0ATPase

An enzyme that uses the energy stored in the proton motive force (𝚫p) to synthesize ATP.

Phosphocreatine

An alternative high-energy phosphate compound used as a substrate for muscle energy.

Phosphocreatine Reduction

A process by which a phosphate group is removed from phosphocreatine and added to ADP to form ATP.

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Phosphocreatine Phosphorylation

The process by which creatine is phosphorylated by ATP to form phosphocreatine.

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Phosphocreatine Mobility

Phosphocreatine can move throughout the cell, like ATP.

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Reversible Phosphocreatine Reaction

The relative rate of ATP versus phosphocreatine production depends on the ratio of substrates and products.

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Reciprocal regulation

The process of regulating metabolic pathways to avoid simultaneous synthesis and breakdown of molecules, preventing wasted energy.

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Metabolic fuel selection

The process of choosing the most appropriate energy source for the body's needs, such as carbohydrates or lipids.

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31P-NMR Spectroscopy

A technique that measures the concentration of ATP and inorganic phosphate using magnetic resonance spectroscopy.

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Direct Calorimetry

A method used to measure the heat produced by biological processes.

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Hess's Law

A law stating that the total energy released by a reaction is constant, no matter the intermediate steps.

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Catabolic state

The metabolic state where the body is breaking down stored energy (catabolism) to meet energy demands.

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Anabolic state

The metabolic state where the body is building up molecules and storing energy (anabolism).

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Basal Metabolic Rate (BMR)

The total amount of energy expended by the body to sustain basic life functions.

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Total Daily Energy Expenditure (TDEE)

The total amount of energy expended by the body over a certain period, including physical activity.

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How does elevation affect gas pressure?

With increasing elevation, the partial pressure of all gases decreases.

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How does elevation affect oxygen absorption?

The lower partial pressure of oxygen at higher elevations makes it harder for your body to absorb oxygen.

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What is acclimatization?

Acclimatization is the process your body goes through to adjust to the lower partial pressure of oxygen at higher altitudes.

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What is hyperventilation?

Hyperventilation is a rapid and deep breathing response to lower oxygen levels at high altitudes.

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What's the Hypoxic Ventilatory Response?

The Hypoxic Ventilatory Response (HVR) is the increased breathing rate caused by low oxygen levels in the blood.

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How does hyperventilation affect gas exchange?

Hyperventilation helps to temporarily increase oxygen absorption and carbon dioxide removal, but it also makes it easier to lose carbon dioxide from the body.

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How does hyperventilation affect blood pH?

Lowering of carbon dioxide levels in the blood leads to a slight increase in pH, making it more alkaline.

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What is the Bohr effect?

The Bohr effect describes how the acidity of blood affects the affinity of hemoglobin for oxygen.

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How does the Bohr effect affect oxygen uptake and release?

The increase in blood pH due to hyperventilation encourages hemoglobin to hold onto oxygen more tightly at the lungs, but it also makes it harder for hemoglobin to release oxygen to the tissues.

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What is 2,3-DPG?

2,3-DPG is a molecule released into circulation that increases the affinity of hemoglobin for oxygen, offsetting the effects of the pH change caused by hyperventilation.

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Refractory Period

The period after an action potential where a neuron cannot fire another action potential, due to the inactivation of sodium channels.

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Why is action potential propagation unidirectional?

The unidirectional propagation of the action potential along the axon, from the site of initiation to the axon terminal.

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Length Constant

The distance along the axon where the membrane potential decays to 37% of its initial value.

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Current Movement Along Axon

The movement of electrical charge along the axon, due to the passive flow of ions.

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Factors Affecting Length Constant

The length constant is affected by factors such as axonal diameter, membrane resistance, and intracellular resistance.

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Impact of Axonal Diameter on Length Constant

A larger axonal diameter decreases membrane resistance, allowing for a longer length constant.

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Impact of Membrane Resistance on Length Constant

A higher membrane resistance increases the length constant, as the signal is less likely to leak out.

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Impact of Intracellular Resistance on Length Constant

A lower intracellular resistance increases the length constant, as the signal encounters less resistance inside the axon.

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Importance of Length Constant

The length constant is crucial for determining the speed of action potential propagation.

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Length Constant in Action

The length constant helps to explain why action potentials travel faster in thicker axons and in neurons with lower membrane resistance.

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Giant Axons in Earthworm Nerve Cord

Large axons in the earthworm nerve cord that transmit action potentials (APs) very quickly, enabling a rapid escape response.

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Myelin Sheath

Specialized cells that wrap around axons to increase the speed of action potential conduction, acting as an insulator.

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Nodes of Ranvier

Gaps between the myelin sheaths along an axon where there is a high concentration of voltage-gated ion channels, allowing for rapid ion exchange and AP transmission.

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Saltatory Conduction

The process where action potentials are conducted more rapidly by hopping between the nodes of Ranvier, skipping over myelinated segments.

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Increased Membrane Resistance (rm)

The increase in membrane resistance due to the myelin sheath, which reduces ion leakage and speeds up action potential propagation.

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Study Notes

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