Biology Chapter 2 Quiz
67 Questions
1 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the primary function of the plasma membrane in a cell?

  • To provide structural support for the cell.
  • To store genetic information.
  • To synthesize proteins.
  • To control the movement of substances into and out of the cell. (correct)
  • Which of the following statements BEST describes the relationship between cellular structure and function?

  • Cellular structure is independent of function, with each component performing a unique task.
  • Cellular structure and function are closely related, where structure dictates the specific function. (correct)
  • Cellular function is primarily determined by the environment, with little influence from structure.
  • Cellular structure and function are unrelated, as cells can adapt to different environments.
  • Which of the following BEST explains the role of the nucleus in a cell?

  • The nucleus safeguards and controls the use of the cell's genetic information. (correct)
  • The nucleus provides structural support and shape to the cell.
  • The nucleus is the primary site of protein synthesis.
  • The nucleus is the site of energy production for the cell.
  • Which of the following cellular components is NOT considered an organelle?

    <p>Cytosol (C)</p> Signup and view all the answers

    What is the significance of the statement "Biochemical activities dictated by subcellular structure" as it relates to the cell?

    <p>The organization of structures within the cell determines its specific capabilities. (B)</p> Signup and view all the answers

    Based on the characteristics discussed, which of the following is the most likely reason for the diversity of cell types in the human body?

    <p>Each cell type possesses a unique set of genes. (D)</p> Signup and view all the answers

    What is the main reason why the cell is considered the fundamental unit of life?

    <p>Cells are the building blocks of all living organisms. (C)</p> Signup and view all the answers

    Which of the following correctly describes the relationship between the cell and the organismal level?

    <p>Individual and collective actions of cells are essential for the organism's survival and function. (A)</p> Signup and view all the answers

    During which phase of mitosis do chromosomes uncoil and revert to chromatin?

    <p>Telophase (A)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of a malignant tumor?

    <p>Does not metastasize (C)</p> Signup and view all the answers

    What is the primary function of the mitotic spindle during mitosis?

    <p>To transport chromosomes toward the poles (C)</p> Signup and view all the answers

    In what way does the protein cyclin contribute to cell division?

    <p>It triggers the transition from interphase to mitosis (D)</p> Signup and view all the answers

    What is the primary difference between apoptosis and necrosis?

    <p>Apoptosis is triggered by injury, while necrosis is programmed cell death (A)</p> Signup and view all the answers

    During which phase of mitosis do sister chromatids line up across the middle of the cell?

    <p>Metaphase (B)</p> Signup and view all the answers

    Which type of microtubules within the mitotic spindle attach to the kinetochore protein on the centromere?

    <p>Those that bind to kinetochore protein on the centromere (A)</p> Signup and view all the answers

    What is the role of actin microfilaments during cytokinesis?

    <p>To create the cleavage furrow that divides the cytoplasm (D)</p> Signup and view all the answers

    What is the name of the structure that holds sister chromatids together during prophase?

    <p>Centromere (D)</p> Signup and view all the answers

    What is the primary function of the Golgi complex?

    <p>Processing and packaging proteins (D)</p> Signup and view all the answers

    Which disorder is associated with the improper secretion of a chloride ion pump protein?

    <p>Cystic fibrosis (B)</p> Signup and view all the answers

    What substances do lysosomes primarily digest?

    <p>Cellular waste and foreign substances (A)</p> Signup and view all the answers

    How are peroxisomes formed within a cell?

    <p>Through division of preexisting peroxisomes (A)</p> Signup and view all the answers

    Which process follows transcription during protein synthesis?

    <p>Translation of mRNA (A)</p> Signup and view all the answers

    What is the main function of mitochondria within a cell?

    <p>Generation of ATP (C)</p> Signup and view all the answers

    In what phase of the cell cycle does DNA replication occur?

    <p>S phase (B)</p> Signup and view all the answers

    Which of the following describes the nucleolus?

    <p>Spherical bodies without a membrane (B)</p> Signup and view all the answers

    What characterizes interphase in somatic cells?

    <p>Doubling of DNA and cytoplasmic growth (C)</p> Signup and view all the answers

    What is the consequence of the absence of a specific lysosomal enzyme in Tay-Sachs disorder?

    <p>Accumulation of glycolipids in nerve cells (C)</p> Signup and view all the answers

    Which of the following processes describes the movement of a substance from a region of high concentration to a region of low concentration through a cell membrane, without the help of membrane proteins?

    <p>Simple diffusion (B)</p> Signup and view all the answers

    What is the primary driving force behind simple diffusion?

    <p>The concentration gradient (C)</p> Signup and view all the answers

    What is the role of transporter proteins in facilitated diffusion?

    <p>To bind to and transport substances across the membrane (D)</p> Signup and view all the answers

    Which of the following factors can influence the rate of simple diffusion?

    <p>The chemical nature of the membrane (A), The size and shape of the diffusing molecule (C)</p> Signup and view all the answers

    What is the difference between channel-mediated and carrier-mediated facilitated diffusion?

    <p>Channel-mediated diffusion involves the formation of a channel through the membrane, while carrier-mediated diffusion involves the binding of a substance to a transporter protein (C)</p> Signup and view all the answers

    What is osmosis?

    <p>The movement of water across a selectively permeable membrane from a region of high water concentration to a region of low water concentration (A)</p> Signup and view all the answers

    What is the role of aquaporins in osmosis?

    <p>To bind to and transport water molecules across the membrane (B)</p> Signup and view all the answers

    What is the difference between a hypotonic solution and a hypertonic solution?

    <p>A hypotonic solution has a lower solute concentration than a hypertonic solution (D)</p> Signup and view all the answers

    What is the difference between primary active transport and secondary active transport?

    <p>Primary active transport uses energy directly from ATP hydrolysis, while secondary active transport uses energy stored in an ionic concentration gradient (C)</p> Signup and view all the answers

    What is the role of the Na+/K+ ATPase pump in maintaining cell homeostasis?

    <p>To maintain a low concentration of Na+ and a high concentration of K+ in the cytosol (C)</p> Signup and view all the answers

    What initiates the process of Na+ ions being transported out of the cell?

    <p>ATP split (C)</p> Signup and view all the answers

    Which of the following correctly describes the action of Na+ symporter proteins?

    <p>Facilitate the inward rush of Na+ with glucose or amino acids. (C)</p> Signup and view all the answers

    What is the primary function of receptor-mediated endocytosis?

    <p>To uptake specific substances by binding to receptor proteins. (C)</p> Signup and view all the answers

    What is one consequence of Digitalis on cardiac cells?

    <p>Decreases Na+ concentration gradient across the membrane. (D)</p> Signup and view all the answers

    How does endocytosis differ from exocytosis?

    <p>Endocytosis involves merging of vesicles with lysosomes. (C)</p> Signup and view all the answers

    Which component of the cytoskeleton is primarily responsible for cell movement?

    <p>Microfilaments (D)</p> Signup and view all the answers

    What is the role of rough ER in a cell?

    <p>Processing and packaging proteins for export. (C)</p> Signup and view all the answers

    Which of the following statements about vesicles is true?

    <p>They can transport substances both into and out of the cell. (A)</p> Signup and view all the answers

    Which type of endocytosis allows cells to take in small droplets of extracellular fluid?

    <p>Pinocytosis (D)</p> Signup and view all the answers

    What are centrosomes primarily involved in?

    <p>Formation of microtubules and mitotic spindle. (B)</p> Signup and view all the answers

    What defines the difference between antiporters and symporters in transport mechanisms?

    <p>Antiporters transport two substances in opposite directions, symporters transport two in the same direction. (A)</p> Signup and view all the answers

    Which component of the cytoplasm is primarily responsible for important chemical reactions?

    <p>Cytosol (A)</p> Signup and view all the answers

    What characterizes lipids within the cytosol?

    <p>They can form aggregates called inclusions. (A)</p> Signup and view all the answers

    What is a primary role of membrane-bound ribosomes?

    <p>Synthesize proteins for the plasma membrane or for export. (B)</p> Signup and view all the answers

    Which of the following is NOT a function of membrane proteins?

    <p>Providing a structural framework for the cell membrane (C)</p> Signup and view all the answers

    Which component of the cell membrane contributes to its fluidity?

    <p>Phospholipids (D)</p> Signup and view all the answers

    Which type of membrane protein spans the entire cell membrane?

    <p>Integral transmembrane proteins (B)</p> Signup and view all the answers

    What is the role of the glycocalyx in the cell membrane?

    <p>To create a sticky surface for cell-cell interactions (D)</p> Signup and view all the answers

    Which of the following molecules can easily pass through the lipid bilayer of the cell membrane?

    <p>Oxygen (O2) (B)</p> Signup and view all the answers

    Which of these describes the movement of a substance from an area of high concentration to an area of low concentration?

    <p>Passive transport (D)</p> Signup and view all the answers

    Which type of transport process utilizes transporter proteins to move substances across the membrane?

    <p>Both B and C (D)</p> Signup and view all the answers

    What is the role of cholesterol in the cell membrane?

    <p>To decrease membrane fluidity (C)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of passive transport?

    <p>Requires cellular energy (C)</p> Signup and view all the answers

    What is the difference between simple diffusion and facilitated diffusion?

    <p>Facilitated diffusion requires a transporter protein, while simple diffusion does not. (C)</p> Signup and view all the answers

    What is meant by the term 'selective permeability' in relation to the cell membrane?

    <p>The membrane only allows certain substances to pass through. (D)</p> Signup and view all the answers

    Which of the following is an example of active transport?

    <p>Movement of sodium ions (Na+) out of a cell (C)</p> Signup and view all the answers

    Which of the following is NOT a component of the phospholipid bilayer?

    <p>Proteins (C)</p> Signup and view all the answers

    Which type of membrane protein is responsible for recognizing and binding to specific substances?

    <p>Receptor proteins (B)</p> Signup and view all the answers

    What is the role of 'linker' proteins in the cell membrane?

    <p>To anchor proteins in the membrane or to other cells (D)</p> Signup and view all the answers

    Which of the following processes involves the movement of large particles into the cell by the formation of vesicles?

    <p>Endocytosis (A)</p> Signup and view all the answers

    Flashcards

    Cell

    The basic living unit of structure and function in all organisms.

    Plasma Membrane

    A flexible barrier that surrounds the cytoplasm of a cell, regulating what enters and exits.

    Cytoplasm

    The jelly-like substance within the cell membrane that contains organelles and cytosol.

    Nucleus

    The control center of the cell that contains genetic material (DNA).

    Signup and view all the flashcards

    Cell Growth

    The process by which a cell increases in size and mass, preparing for division.

    Signup and view all the flashcards

    Mitosis

    The process of cell division that results in two identical daughter cells.

    Signup and view all the flashcards

    Cell Organelles

    Specialized structures within the cytoplasm that perform specific functions for the cell.

    Signup and view all the flashcards

    Cellular Diversity

    The variety of cell types and their functions in the human body, totaling about 200 different types.

    Signup and view all the flashcards

    Simple Diffusion

    Movement of particles from high to low concentration until equilibrium.

    Signup and view all the flashcards

    Factors Affecting Diffusion

    Key elements influencing the rate of diffusion include concentration gradient, temperature, and surface area.

    Signup and view all the flashcards

    Facilitated Diffusion

    Process where transmembrane proteins assist solutes in passing through the membrane.

    Signup and view all the flashcards

    Transporter Proteins

    Proteins that bind substances and undergo conformational changes to transport them across membranes.

    Signup and view all the flashcards

    Osmosis

    Net movement of water through a membrane from high to low water concentration.

    Signup and view all the flashcards

    Isotonic Solution

    Solution where water concentration is equal inside and outside the cell, leading to no net movement.

    Signup and view all the flashcards

    Hypotonic Solution

    Solution where water concentration is higher outside the cell, potentially causing hemolysis.

    Signup and view all the flashcards

    Hypertonic Solution

    Solution where water concentration is lower outside the cell, causing crenation.

    Signup and view all the flashcards

    Active Transport

    Movement of substances against their concentration gradient, requiring energy from ATP.

    Signup and view all the flashcards

    Na+/K+ ATPase Pump

    A primary active transport protein maintaining Na+ low and K+ high inside cells using ATP.

    Signup and view all the flashcards

    Na+/K+ Pump

    A membrane protein that moves 3 Na+ out and 2 K+ in using ATP energy.

    Signup and view all the flashcards

    Secondary Active Transport

    Uses ion gradients to move substances against their concentration gradient.

    Signup and view all the flashcards

    Symporter

    A transporter that moves two substances in the same direction across a membrane.

    Signup and view all the flashcards

    Antiporter

    A transporter that moves two substances in opposite directions across a membrane.

    Signup and view all the flashcards

    Digitalis

    A drug that slows the sodium pump in heart cells, increasing Ca2+ levels.

    Signup and view all the flashcards

    Exocytosis

    The process of vesicles fusing with the plasma membrane to release contents.

    Signup and view all the flashcards

    Endocytosis

    The process of taking substances into the cell via vesicles.

    Signup and view all the flashcards

    Phagocytosis

    'Cell eating' process where cells engulf large particles or bacteria.

    Signup and view all the flashcards

    Pinocytosis

    'Cell drinking' where cells take in liquid and small molecules.

    Signup and view all the flashcards

    Receptor-Mediated Endocytosis

    Selective process where ligands bind to receptors and enter cells.

    Signup and view all the flashcards

    Cytoskeleton

    Network of protein filaments that provide support and shape to the cell.

    Signup and view all the flashcards

    Microfilaments

    The thinnest filaments, primarily composed of actin, for shape and movement.

    Signup and view all the flashcards

    Rough Endoplasmic Reticulum

    Membrane network with ribosomes, involved in protein synthesis and processing.

    Signup and view all the flashcards

    Smooth Endoplasmic Reticulum

    Membrane network without ribosomes, synthesizes lipids and detoxifies substances.

    Signup and view all the flashcards

    Fluid Mosaic Model

    Describes the plasma membrane's structure as a bilayer of lipids with dispersed proteins.

    Signup and view all the flashcards

    Phospholipid Bilayer

    Two layers of phospholipid molecules forming the main structure of the cell membrane.

    Signup and view all the flashcards

    Glycolipids

    Lipids with bound carbohydrate groups, contributing to the cell membrane's structure and function.

    Signup and view all the flashcards

    Cholesterol in Membrane

    20% of membrane lipids, it stabilizes membrane fluidity and reduces permeability.

    Signup and view all the flashcards

    Integral Proteins

    Proteins that extend into or across the cell membrane, vital for transport and signaling.

    Signup and view all the flashcards

    Peripheral Proteins

    Proteins located on the inner or outer surface of the membrane, easily removed.

    Signup and view all the flashcards

    Passive Transport

    Movement of substances across the membrane without energy input, down their concentration gradient.

    Signup and view all the flashcards

    Selective Permeability

    The cell membrane's ability to allow some substances to pass while blocking others.

    Signup and view all the flashcards

    Concentration Gradient

    Differences in the concentration of a substance across a space, driving diffusion.

    Signup and view all the flashcards

    Electrochemical Gradient

    Combined difference in concentration and charge across a membrane, influencing ion movement.

    Signup and view all the flashcards

    Channel Proteins

    Integral proteins that form passages to allow specific substances to cross the membrane.

    Signup and view all the flashcards

    Vesicular Transport

    Transport of materials across the cell membrane in small vesicles (exocytosis or endocytosis).

    Signup and view all the flashcards

    S Phase

    The stage in interphase where DNA is replicated.

    Signup and view all the flashcards

    Prophase

    The first stage of mitosis, where chromatin condenses into chromosomes.

    Signup and view all the flashcards

    Metaphase

    A stage in mitosis where chromatids align in the middle of the cell.

    Signup and view all the flashcards

    Anaphase

    The stage of mitosis where chromatids move to opposite poles of the cell.

    Signup and view all the flashcards

    Telophase

    The final stage of mitosis characterized by the reformation of the nucleus.

    Signup and view all the flashcards

    Cytokinesis

    The division of the cytoplasm, creating two daughter cells.

    Signup and view all the flashcards

    Cyclin

    A protein that regulates the cell cycle by initiating mitosis.

    Signup and view all the flashcards

    Apoptosis

    Programmed cell death that occurs when triggered.

    Signup and view all the flashcards

    Hyperplasia

    An increase in the number of cells, often seen in tumors.

    Signup and view all the flashcards

    Carcinogenesis

    The multistep process of cancer development.

    Signup and view all the flashcards

    Golgi Complex

    Organelles made of flattened sacs that process and package proteins from the rough ER.

    Signup and view all the flashcards

    Cystic Fibrosis

    A genetic disorder caused by improper secretion of chloride ion pump from the Golgi, leading to thick mucus buildup.

    Signup and view all the flashcards

    Lysosomes

    Membranous vesicles that contain digestive enzymes, formed in the Golgi complex.

    Signup and view all the flashcards

    Tay-Sachs Disorder

    A genetic disorder in children, due to absence of a lysosomal enzyme, leading to nerve cell dysfunction.

    Signup and view all the flashcards

    Peroxisomes

    Small membranous vesicles that oxidize organic materials and detoxify harmful substances.

    Signup and view all the flashcards

    Mitochondria

    Double-membraned organelles that generate ATP, known as the powerhouse of the cell.

    Signup and view all the flashcards

    Nucleus Function

    The control center containing DNA in chromosomes, which directs protein synthesis.

    Signup and view all the flashcards

    Transcription

    The process of copying DNA to synthesize messenger RNA.

    Signup and view all the flashcards

    Translation

    The process where mRNA is translated into an amino acid sequence to form proteins.

    Signup and view all the flashcards

    Cell Cycle

    The series of events that a cell goes through to grow and divide, including interphase and mitosis.

    Signup and view all the flashcards

    Study Notes

    Course Information

    • Course: PHARM. 181: INTRODUCTION TO HUMAN ANATOMY & PHYSIOLOGY I
    • Instructor: Charles Ansah, PhD; FPCPharm; FGHCPharm
    • Professor of Pharmacology & Toxicology/Former Dean & Pro Vice-Chancellor
    • Location: Room C118 Tackie Building, Department of Pharmacology, Faculty of Pharmacy & Pharmaceutical Sciences, College of Health Sciences, KNUST

    Cellular Level of Organization

    • Cells are basic, living, structural and functional units of life
    • Organismal activity depends on individual and collective activity of cells
    • Biochemical activities are dictated by subcellular structure
    • General functions of the cell include compartmentalization of biochemical reactions within specialized structures, regulation of inflow & outflow of materials, use of genetic material to direct cell activities, and continuity of life originates from the cell.

    Cellular Diversity

    • 100 trillion cells in the body, with 200 different types
    • Cells vary in size and shape, with different shapes correlating to their specific functions.

    Parts of a Cell

    • Plasma (cell) membrane
    • Cytoplasm (cytosol and organelles)
    • Nucleus (chromosomes and genes)

    A Typical Cell (Diagram)

    • Various organelles are labeled on the diagram.

    Plasma Membrane (PM)

    • Flexible but sturdy barrier surrounding cytoplasm
    • Fluid Mosaic Model:
      • Double (bilayer) lipid layer with embedded and dispersed proteins
      • Lipids are barriers to polar substances
      • Proteins regulate traffic (act as gatekeepers)
      • Bilayer consists of phospholipids, cholesterol, and glycolipids
      • Glycolipids are lipids with carbohydrates attached
      • Phospholipids have both hydrophobic and hydrophilic poles. (hydro phobic tails, hydrophilic heads).

    Lipid Bilayer

    • Two back-to-back layers of lipid molecules
    • Cholesterol and glycolipids scattered among phospholipid molecules

    Phospholipids

    • Comprise 75% of lipids
    • Phospholipid bilayer = 2 parallel layers of molecules
    • Each molecule is amphipathic (polar and non-polar regions)
      • Polar parts (heads) are hydrophilic and face watery environments on both surfaces
      • Nonpolar parts (tails) are hydrophobic and line up in the interior.

    Glycolipids

    • Comprise 5% of lipids
    • Carbohydrate groups form a polar head on the side of the membrane facing the extracellular fluid.

    Cholesterol

    • Comprises 20% of cell membrane lipids
    • Stiff steroid rings and hydrocarbon tail are non-polar and hide in the middle of the cell membrane

    Types of Membrane Proteins

    • Integral proteins
      • Extend into or completely across the cell membrane.
      • Transmembrane proteins if they extend completely across the membrane
      • Glycoproteins have a sugar portion facing the extracellular fluid to form a glycocalyx; this gives the cell "uniqueness" and creates stickiness to hold it to other cells (or creates a slippery surface).
    • Peripheral proteins
      • Attached to either inner or outer surface
      • Easily removed

    Membrane Protein Functions (I)

    • Channel Proteins
      • Allow specific substances to move through the water-filled pore
    • Transporter Proteins
      • Change shape to transport specific substances (e.g., amino acids) across the membrane
    • Receptor Proteins
      • Recognize ligands and change the cell's function (e.g., in the kidney's altering water permeability)

    Summary of Membrane Protein Functions (II)

    • Cell Identity Marker
    • Linker
    • Act as an Enzyme

    Membrane Fluidity

    • Membranes are fluid structures (like an oil layer)
    • Self-sealing if punctured
    • Membrane molecules can rotate, and move freely
    • Difficult for hydrophilic parts to pass through the hydrophobic core of the lipid bilayer

    Selective Permeability of the Membrane

    • Lipid bilayer is permeable to nonpolar, uncharged molecules (e.g., oxygen, CO2, steroids) and water. Water can flow through gaps in the hydrophobic lipid core.
    • Transmembrane proteins act as specific channels for smaller and medium polar, and charged particles.
    • Macromolecules cannot directly pass through the membrane, requiring vesicular transport.

    Gradients Across the Plasma Membrane

    • Membrane maintains differences in concentration of substances (concentration gradient)
    • Membrane maintains differences in charged ions (electrical gradient or membrane potential).
    • These gradients together create an electrochemical gradient
    • Substances move down their concentration gradient and toward the oppositely charged area.

    Transport Across the Plasma Membrane

    • Passive Processes
      • Simple diffusion
      • Facilitated diffusion
      • Osmosis
    • Active Processes
      • Active transport
      • Vesicular transport

    Transport Across Membranes (Summary)

    • Mediated transport requires transporter protein
    • Non-mediated transport does not use a transporter protein
    • Active transport uses ATP to move against the concentration gradient
    • Passive transport moves down the concentration gradient using kinetic energy only
    • Vesicular transport occurs in small vesicles (exocytosis and endocytosis).

    Diffusion Through the Lipid Bilayer

    • Important for nutrient absorption and waste excretion of non-polar, hydrophobic molecules like oxygen, carbon dioxide, nitrogen, fatty acids, steroids, small alcohols, ammonia, and fat-soluble vitamins (A, E, D, and K).

    Diffusion Through Membrane Channels

    • Each channel protein is specific for particular ions (K+, Cl−, Na+, or Ca2+)
    • Slower than simple diffusion, but still very rapid.
    • Channels may be open all the time or gated (controlled processes).

    Passive Processes

    • Simple Diffusion
    • Facilitated Diffusion
    • Osmosis

    Simple Diffusion

    • Crystal of dye in water, dye diffuses from higher to lower concentration.
    • Influenced by: concentration gradient, temperature, mass of the diffusing substance, surface area, diffusion distance.

    Principles of Diffusion

    • Random mixing of particles due to kinetic energy
    • Greater difference in concentration = faster rate of diffusion
    • Higher temperature = faster rate of diffusion
    • Larger substance = slower rate of diffusion.
    • Increase in surface area = faster rate of diffusion
    • Longer distance = slower rate of diffusion
    • Equilibrium reached when molecules are evenly distributed.

    Facilitated Diffusion

    • Transmembrane proteins help polar or highly charged solutes pass through the lipid bilayer.
    • Two types: channel-mediated and carrier-mediated

    Facilitated Diffusion of Glucose

    • Glucose binds to a transporter protein.
    • Transporter protein changes shape to move glucose into cells.
    • Glucose moves only down a concentration gradient.
    • Kinase enzymes convert glucose into glucose-6-phosphate, reducing concentration of glucose inside the cell.
    • Transporter proteins always bring glucose into the cell.

    Channel Mediated Facilitated Diffusion

    • Illustrates specifics of how a channel works to move K+ across a membrane (e.g., opening/closing).

    Carrier Mediated Facilitated Diffusion

    • Illustrates specifics of how a carrier protein works to move glucose across a membrane.

    Diffusion: A Comparison

    • Compares simple diffusion, channel-mediated, and carrier-mediated facilitated diffusion

    Osmosis

    • Net movement of water through a selectively permeable membrane from an area of higher water concentration to an area of lower water concentration.
    • Occurs if the membrane is permeable to water but not to certain solutes.
    • Water diffuses through the lipid bilayer or through aquaporins (transmembrane proteins that act as water channels).

    Osmosis of Water Through a Membrane

    • Net movement of water from one side of a selectively permeable membrane to the other until hydrostatic pressure (equal or more balanced osmotic pressure) stops net water movement.

    Tonicity Effects on RBCs in the Lab

    • Isotonic solution: osmotic pressure of cell equals fluid outside the cell; cell volume constant
    • Water enters the cell faster than it leaves;
    • Water enters and leaves the cell in equal amounts.

    Effects of Tonicity on Cell Membranes

    • Isotonic solutions (same water concentration inside and outside the cell) result in no net movement of water across the cell membrane.
    • Hypotonic solutions (greater water concentration outside the cell) result in hemolysis.
    • Hypertonic solutions (lower water concentration outside the cell) result in crenation.

    Active Transport

    • Movement of polar or charged substances against their concentration gradient.
    • Requires energy (e.g., from ATP hydrolysis). Two types:
      • Primary active transport (uses ATP directly)
      • Secondary active transport (uses an electrochemical gradient).

    Primary Active Transport

    • ATP energy changes a transporter protein's shape, resulting in a substance being pumped across a plasma membrane against its concentration gradient.
    • Na+/K+ ATPase is the most common example (actively pumps Na+ out of the cell and K+ into the cell). Critical to maintaining osmotic pressure across the membrane.

    Secondary Active Transport

    • Uses energy stored in an ionic concentration gradient to move other substances against their own concentration gradient.
    • Na+/K+ pump maintains a low concentration of Na+ inside cells
    • The gradient (the Na+ leaking back inside) provides energy for other substances to be transported.
    • symporters move substances in the same direction , antiporters move substances in opposite directions

    Antiporters and Symporters (Diagram)

    Digitalis

    • Slows the sodium pump, letting more Na+ accumulate in heart muscle cells, which increases the force of contraction.

    Vesicular Transport of Particles

    • Exocytosis: vesicles inside the cell fuse with the plasma membrane, releasing their contents (e.g., digestive enzymes, hormones, neurotransmitters, or waste).
    • Endocytosis
      • Phagocytosis: cell eating (e.g., macrophages engulfing bacteria).
      • Pinocytosis: cell drinking (no pseudopods involved; nonselective input of extracellular fluid)
      • Receptor-mediated endocytosis: selective input (e.g., receptor for LDL or a virus)

    Active Transport in Vesicles: Receptor-mediated Endocytosis (diagram)

    • Mechanism for uptake of specific substances

    Active Transport in Vesicles: Phagocytosis (diagram)

    • Mechanism for cell eating

    Active Transport in Vesicles: Bulk-Phase Endocytosis (Pinocytosis) (diagram)

    Pinocytosis and Phagocytosis (diagram)

    Active Transport in Vesicles: Exocytosis and Transcytosis

    • Exocytosis: membrane-enclosed secretory vesicles fuse with the plasma membrane, releasing contents into the extracellular fluid.
    • Transcytosis: combined endocytosis and exocytosis to move substances from one side of a cell across and out the other side.

    Comparison of Transport Types

    • Table comparing passive (diffusion, simple diffusion, facilitated diffusion, osmosis) and active transport (primary, secondary, vesicular) processes

    Cell Organelles

    • Nonmembranous organelles do not have membranes and are in direct contact with the cytoplasm. Examples include microfilaments, intermediate filaments, microtubules.
    • Membranous organelles have one or two lipid bilayer membranes. Examples include ER, Golgi apparatus, lysosomes, peroxisomes, and mitochondria.

    Cytosol (Intracellular Fluid)

    • 55% of cell volume
    • 75-90% water
    • Large organic molecules (proteins, carbohydrates, and lipids) suspended by electrical charges
    • Small organic molecules (simple sugars) and ions
    • Dissolved substances like inclusions (aggregates of a single material), lipid droplets, and glycogen granules.

    Cytoskeleton

    • Network of protein filaments throughout the cytosol
    • Gives cell support, shape, organizes chemical reactions, and allows movement.

    Microfilaments, Intermediate Filaments, Microtubules

    • Structural components of the cytoskeleton
    • Different roles (support, motility, etc)

    Centrosome

    • Formation site for mitotic spindle and microtubules needed for cell division
    • Contains two centrioles arranged at 90 degrees to each other

    Ribosomes

    • Synthesize proteins
    • Free ribosomes synthesize proteins for use inside the cell.
    • Membrane-bound ribosomes synthesize proteins needed for the plasma membrane or export.
    • Multiple ribosomes can work together as a polyribosome.

    Endoplasmic Reticulum (ER)

    • Network of membranes forming flattened sacs (cisternae)
      • Rough ER: continuous with nuclear envelope, covered in ribosomes; synthesizes, processes, and packages proteins for export; synthesizes proteins locally for use.
      • Smooth ER: no attached ribosomes; synthesizes phospholipids, steroid, fats, detoxifies harmful substances (e.g., alcohol).

    Golgi Complex

    • 3–20 flattened, curved membranous sacs (cisternae)
    • Convex side faces ER and concave side faces the cell membrane
    • Processes and packages proteins (produced by rough ER).

    Packaging By Golgi Complex (diagram)

    • Shows process of how proteins are packaged and transferred.

    Cystic Fibrosis

    • Deadly inherited disorder due to a defect in the chloride ion pump protein secreted by the Golgi or rough ER
    • Imbalance in fluid and ion transport across the plasma membrane results in a buildup of thick mucus outside certain cells.

    Lysosomes

    • Membranous vesicles formed in the Golgi complex
    • Contain digestive enzymes
    • Digest foreign substances and recycle organelles.

    Tay-Sachs Disorder

    • Genetic disorder in children of Eastern European descent
    • Absence of a single lysosomal enzyme, which normally breaks down a glycolipid.
    • Glycolipid accumulates, nerve cells lose functionality, and result in seizures, muscle rigidity, blindness, dementia, death before age 5.

    Peroxisomes

    • Membranous vesicles smaller than lysosomes (-formed by preexisting ones)
    • Contain enzymes to oxidize organic material (eg amino acids and fatty acids, toxic substances like alcohol & formaldehyde)
    • Contain catalase that breaks down H2O2

    Mitochondria

    • Double membrane organelle (outer and inner mitochondrial membrane)
    • Inner membrane folds are called cristae
    • Central cavity is the matrix; increased surface area for chemical reactions;
    • Generate ATP (energy); mitochondria replicate and increase number according to need.

    Nucleus

    • Large organelle with a double membrane nuclear envelope; continuous with rough ER.
    • Perforated by water-filled nuclear pores
    • Contains the nucleolus, which is a spherical, dark body within the nucleus (no membrane), site of ribosome assembly. The nucleus contains chromatin—loosely packed DNA in non-dividing cells and chromosomes (tightly packed DNA) in dividing cells.

    Function of Nucleus

    • DNA is organized into 46 chromosomes.
    • Instructions on each chromosome direct the synthesis of specific proteins.
    • Non-dividing cells contain nuclear chromatin (loosely packed DNA); dividing cells contain chromosomes (tightly packed DNA before condensing); DNA is copied before condensing.

    Protein Synthesis (diagram)

    • Transcription and translation steps that show where they are happening within the cell.

    Transcription

    • DNA sense strand is used as a template to create a messenger RNA (mRNA) strand.

    Translation

    • mRNA, rRNA, and tRNA work together to make a specific protein.

    Normal Cell Division

    • Mitosis (somatic cell division) -one parent cell gives rise to 2 identical daughter cells; mitosis= nuclear division; cytokinesis = cytoplasmic division occurring billions of times a day for tissue repair and growth.
    • Meiosis (reproductive cell division) -egg and sperm cell production, only in testes and ovaries

    The Cell Cycle in Somatic Cells

    • Process of cell duplication and division
    • Chromosomes must be duplicated to pass genes correctly; genes are passed on correctly via mitosis (4 stages: prophase, metaphase, anaphase, and telophase)
    • Cytoplasmic division (cytokinesis) also occurs.

    Interphase Stage of Cell Cycle

    • Phases of interphase (G1, S, G2)
    • G1 = cytoplasm increase (resting stage for non-dividing cells);
    • S = DNA replication
    • G2 = cytoplasmic growth

    Replication of Chromosomes

    • Doubling of genetic material (DNA replication) during interphase (S phase)
    • DNA unzips; mirror copy is formed (complementary bases) from each old strand (two complete identical DNA molecules are formed).

    Stages of Nuclear Division: Mitosis (diagram)

    • Shows individual stages of cell division.

    Prophase

    • Chromatin condenses to form chromosomes
    • Nucleolus and nuclear envelope disappear
    • Centrosomes move to opposite ends
    • Mitotic spindle forms (microtubules)

    Metaphase

    • Chromatids align at the metaphase plate (middle of cell).

    Anaphase

    • Sister chromatids separate and move towards opposite poles of the cell

    Telophase

    • Chromosomes arrive at poles, uncoil to become chromatin
    • Nucleoli and nuclear envelopes reform
    • Mitotic spindle breaks down

    Cytokinesis

    • Division of the cytoplasm (and organelles)
    • Cleavage furrow forms by actin microfilaments, which indent the plasma membrane
    • This division is perpendicular to the mitotic spindle to separate chromosomes correctly
    • Results in two daughter cells returning to interphase.

    Control of Cell Destiny

    • Cell destinies include remaining active, growing/dividing, or dying
    • Homeostasis maintains cell multiplication and cell death balance
    • The protein cyclin builds up during interphase (and triggers mitosis)
    • Programmed cell death (apoptosis)
    • Necrosis (cell death from injury or infection)

    Aging

    • Body's adaptive capacity decreases with age.
    • Theories for aging include limited cell divisions, glucose binding to proteins, free radicals, and autoimmune responses
    • Aging evidence includes damaged skin, hardened arteries, and stiff joints.

    Cancer

    • Out of control cell division
    • Hyperplasia, benign to malignant tumours
    • Causes include carcinogens, x-rays, and viruses
    • Mutations in genes that regulate growth and development lead to uncontrolled growth factors
    • Carcinogenesis is a multistep process taking years and requiring multiple mutations.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Description

    Test your knowledge on cellular biology with this quiz focusing on the plasma membrane, nucleus, and the relationship between cellular structure and function. It covers fundamental concepts essential for understanding the significance of cells in living organisms.

    More Like This

    Cell Structure and Composition Quiz
    5 questions
    Cytology hard
    20 questions

    Cytology hard

    WiseTropicalIsland4758 avatar
    WiseTropicalIsland4758
    The Cell - organisation
    28 questions

    The Cell - organisation

    UserFriendlySagacity4401 avatar
    UserFriendlySagacity4401
    Use Quizgecko on...
    Browser
    Browser