BIOL 4130H Human Cell Biology Quiz
49 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the weight of the final exam in the course evaluation?

  • 30% (correct)
  • 15%
  • 50%
  • 20%

    • Journal Article Quizzes can be made up if a student misses the scheduled date.

    False

    What is the email address of Dr. Robert Huber?

    The course textbook is titled _____ World of the Cell.

    <p>Becker's</p> Signup and view all the answers

    Match the following evaluations with their corresponding percentages:

    <p>Journal Article Critique = 15% Research Proposal = 20% Midterm = 20% Final Exam = 30%</p> Signup and view all the answers

    When is the midterm exam scheduled?

    <p>October 28</p> Signup and view all the answers

    Office hours for Dr. Robert Huber are specified in the course details.

    <p>False</p> Signup and view all the answers

    Lectures for BIOL 4130H are held on _____ at 7:00 PM.

    <p>Mondays</p> Signup and view all the answers

    What allows HeLa cells to not age or die?

    <p>Abnormal telomerase expression</p> Signup and view all the answers

    HeLa cells shorten their telomeres and thus age like normal cells.

    <p>False</p> Signup and view all the answers

    What did the estate of Henrietta Lacks seek from ThermoFisher?

    <p>Financial disclosure about how much money was made from the commercialization of her cells.</p> Signup and view all the answers

    HeLa cells do not undergo normal aging due to their expression of _____, which prevents telomere shortening.

    <p>telomerase</p> Signup and view all the answers

    Match the following aspects regarding Henrietta Lacks with their descriptions:

    <p>ThermoFisher = Company involved in the lawsuit HeLa cells = Cells that do not age or die Estate of Henrietta Lacks = Requested financial disclosure Settlement = Agreement reached with ThermoFisher</p> Signup and view all the answers

    What happens if a student misses the midterm?

    <p>Their grade will go to the final exam</p> Signup and view all the answers

    A late penalty of 10% is imposed for every day an assignment is late.

    <p>False</p> Signup and view all the answers

    Name the three strands of biological inquiry that contribute to modern cell biology.

    <p>Cytology, Biochemistry, Genetics</p> Signup and view all the answers

    Students should ensure to take detailed ______ during lectures.

    <p>notes</p> Signup and view all the answers

    Match the scientific focus to its definition:

    <p>Cytology = Focuses on cellular structure using optical techniques Biochemistry = Studies cellular structure, function, and metabolism Genetics = Examines information flow and heredity Cellular approaches = Utilizes light microscopy and other techniques</p> Signup and view all the answers

    Which of the following is a learning objective of the course?

    <p>To critically analyze primary literature</p> Signup and view all the answers

    Students are encouraged to wait until the last minute to ask for help.

    <p>False</p> Signup and view all the answers

    Recent technological advances have improved knowledge about the ______.

    <p>human cell</p> Signup and view all the answers

    Which treatment strategy prevents the formation of amyloid plaques in Alzheimer’s disease?

    <p>RNAi to inhibit translation of plaque-associated proteins</p> Signup and view all the answers

    Light microscopy is generally used for observing living cells.

    <p>False</p> Signup and view all the answers

    What is the primary advantage of phase contrast microscopy?

    <p>It allows the examination of living cells by providing different levels of brightness.</p> Signup and view all the answers

    Differential interference contrast microscopy is preferred for examining __________ cells.

    <p>living</p> Signup and view all the answers

    Match the microscopy technique with its description:

    <p>Phase contrast microscopy = Examines behavior of living cells Fluorescence microscopy = Uses fluorescent dyes to visualize structures Confocal microscopy = Provides 3D images with improved resolution Light microscopy = Used for fixed tissues highlighting cell shape</p> Signup and view all the answers

    What is one potential side effect of using Aβ polypeptides in treatments?

    <p>They are necessary for neuronal function</p> Signup and view all the answers

    Fluorescence microscopy can only be used on fixed tissues.

    <p>False</p> Signup and view all the answers

    What is the result of phase-shifting in phase contrast microscopy?

    <p>Different parts of the cell appear as different levels of brightness.</p> Signup and view all the answers

    What is the primary function of nucleic acids?

    <p>Store, transmit, and express genetic information</p> Signup and view all the answers

    All lipids are formed through linear polymerization.

    <p>False</p> Signup and view all the answers

    What type of proteins act as catalysts in chemical reactions?

    <p>Enzymes</p> Signup and view all the answers

    Aβ polypeptides are not soluble in the _______ environment.

    <p>extracellular</p> Signup and view all the answers

    Match the following classes of proteins with their functions:

    <p>Enzymes = Increase reaction rates Motility proteins = Facilitate movement Structural proteins = Provide physical support Transport proteins = Move substances across membranes</p> Signup and view all the answers

    Which type of proteins is involved in cell communication?

    <p>Signaling proteins</p> Signup and view all the answers

    Most forms of Alzheimer's Disease are hereditary.

    <p>False</p> Signup and view all the answers

    What protein is hyperphosphorylated in neurofibrillary tangles in Alzheimer's Disease?

    <p>Tau</p> Signup and view all the answers

    Tau functions to stabilize _______.

    <p>microtubules</p> Signup and view all the answers

    What role does apolipoprotein E (APOE) have in Alzheimer's Disease?

    <p>It is involved in cholesterol transport</p> Signup and view all the answers

    What type of antibodies are produced when an animal's immune system responds to an antigen?

    <p>Polyclonal antibodies</p> Signup and view all the answers

    Monoclonal antibodies are non-renewable.

    <p>False</p> Signup and view all the answers

    What are the two regions of an antibody that are identical to each other but unique for each antibody called?

    <p>Variable regions</p> Signup and view all the answers

    Antibodies produced from cultured hybrid cells are called __________.

    <p>monoclonal antibodies</p> Signup and view all the answers

    Match the type of antibody with its characteristic:

    <p>Polyclonal antibodies = Non-renewable and recognize different sites Monoclonal antibodies = Renewable and single specificity Hybridomas = Cells resulting from fusion of B lymphocytes and myeloma cells Antigen-binding site = Region that attaches to a specific antigen</p> Signup and view all the answers

    What is one major drawback of polyclonal antibodies?

    <p>They are non-renewable</p> Signup and view all the answers

    Phagocytic cells function to destroy antigens by digesting them.

    <p>True</p> Signup and view all the answers

    What is the role of plasma B cells in the immune response?

    <p>They produce antibodies that bind to and inactivate antigens.</p> Signup and view all the answers

    The constant region of an antibody is __________ for all antibodies of a particular type.

    <p>the same</p> Signup and view all the answers

    Which animal is NOT commonly used for antibody production?

    <p>Goldfish</p> Signup and view all the answers

    Study Notes

    Course Information

    • Course: BIOL 4130H Human Cell Biology
    • Instructor: Dr. Robert Huber
    • Email: [email protected]
    • Office: LHS D243
    • Labs: LHS D244/246
    • Office Hours: Email for appointment
    • Lectures: Mondays 7:00 PM - 8:50 PM, ENW 103
    • Tutorials: Mondays 9:00 PM - 9:50 PM, ENW 103 (check syllabus for schedule)

    Textbook

    • Becker's World of the Cell (Hardin/Lodolce), 10th Edition
    • ISBN (eText): 9780135832356
    • ISBN (180-day rental): 9780135832318
    • Purchase options: Trent University Bookstore or Pearson

    Course Evaluation

    • Journal Article Critique: 15%
    • Research Proposal: 20%
    • Journal Article Quizzes (2): 7.5% each
    • Midterm Exam: 20%
    • Final Exam: 30%
    • Late submissions: 5% deduction per day late

    Learning Objectives

    • Understand conserved cellular processes
    • Understand how cell malfunction causes human disease
    • Understand advancements in technology improving human cell knowledge
    • Learn to critically analyze primary literature related to cell biology and diseases
    • Communicate ideas and hypotheses in research proposals

    Lecture Outline

    • Lecture 1: Overview of cell biology, macromolecules of the cell, cellular approaches and techniques

    • Emerging strands of biological inquiry: Cytology, biochemistry, genetics

    Microscopy

    • Light Microscopy: Examine fixed or living cells, use staining, and observe large organelles and tissues.
    • Specialized Light Microscopy: Phase contrast, DIC, fluorescence, and confocal microscopes. Each technique utilizes different methods of manipulation.
    • Electron Microscopy (TEM, SEM): Examine microscopic structures to a high resolution using electrons, examine whole organisms and other samples in 3D
    • Immunofluorescence: Use labeled antibodies to detect specific proteins within cells, use direct or indirect methods
    • Fluorescence vs. Confocal Microscopy: Confocal uses lasers, detects one plane to eliminate blurring

    Macromolecules of the Cell

    • Nucleic Acids (DNA/RNA): Store, transmit, express genetic information
    • Polysaccharides: Structure and storage, polymers of sugars
    • Lipids: Energy storage, membrane structure, signal transduction
    • Proteins: Chemical reactions, structural support, movement, and signaling

    Antibodies

    • Function: Used in research to detect specific proteins
    • Polyclonal Antibodies: Produced from multiple B cells; less specific but more readily available.
    • Monoclonal Antibodies: Produced from one B cell; highly specific, but difficult to produce.
    • Immunofluorescence: Antibody detection method using fluorescent probes

    Model Systems

    • Model organisms (e.g., bacteria, yeast, fruit flies, roundworms, mice and plants) provide insights into human cellular systems in the lab.

    Cells and Tissue Cultures

    • Used as model systems for cancer, viruses, and cell differentiation in cells or tissues
    • Immortal cells (e.g., HeLa cells): Do not age or die, useful for research.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Related Documents

    Description

    Test your understanding of key concepts in Human Cell Biology. This quiz covers material from Becker's World of the Cell and includes aspects of cellular processes, disease, and technological advancements. Perfect for students in Dr. Huber's course to prepare for exams and critiques.

    More Like This

    Cellular Physiology and Transport Quiz
    5 questions

    Cellular Physiology and Transport Quiz

    TerrificWonder6615 avatar
    TerrificWonder6615
    Cell Communication Methods Quiz
    2 questions

    Cell Communication Methods Quiz

    RichRococo avatar
    RichRococo
    Anatomy and Physiology: Cellular Level of Organization
    10 questions

    Anatomy and Physiology: Cellular Level of Organization

    MagicalMoldavite6694 avatar
    MagicalMoldavite6694
    The Human Cell Quiz
    37 questions

    The Human Cell Quiz

    BetterKnownTungsten1727 avatar
    BetterKnownTungsten1727
    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser