Questions and Answers
Match the drug resistance to the appropriate cell lines:
NSCLC = Greater resistance to all four drugs SCLC = Less resistance to drugs
Why does active transport require ATP?
An input of energy is needed to allow the movement of molecules from an area of low concentration to one of higher concentration.
The movement of water into, or out of, a cell is an example of:
What factors are required for net movement of a substance to occur by facilitated diffusion?
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The sodium-potassium pump is an example of:
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What process do plasma membranes of some plant cells use to move protons out of the cell?
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The random movement of molecules is referred to as:
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What is the potential of an unstimulated neuron (resting potential)?
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How did membrane potential change when the red probe measured it during the nerve impulse?
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Why do over-expressed MRP proteins confer resistance to multiple different drugs?
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What was the single best description of the data shown regarding MRP2 mRNA in NSCLC and SCLC?
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Study Notes
Multi-Drug Resistance and Tumor Cells
- Non-small cell lung carcinoma (NSCLC) exhibits higher resistance to four different drugs compared to small cell lung carcinoma (SCLC).
- MRP genes, associated with multi-drug resistance (MDR), are vital for understanding drug resistance mechanisms in tumors.
Active Transport Mechanisms
- Active transport requires ATP because energy input is essential for moving molecules against their concentration gradient, from low to high concentration.
- Examples of active transport include sodium-potassium pumps and proton transport in plant cells, where transport proteins move substances against their concentration gradients.
Movement of Water and Molecules
- The movement of water across membranes is known as osmosis, while the random movement of molecules without a gradient is referred to as diffusion.
- Facilitated diffusion necessitates three factors: a concentration gradient, a transport protein, and an intact plasma membrane for net substance movement.
Membrane Potential in Neurons
- An unstimulated neuron, at resting potential, measures approximately -65 mV.
- During a nerve impulse, membrane potential becomes less negative when measured, indicating a depolarization event.
Role of MRP Proteins
- MRP proteins transport waste products and certain chemotherapy drugs out of cells, which can lead to resistance against multiple drugs when these proteins are over-expressed.
- The abundance of MRP2 mRNA was significantly higher in some NSCLC tumor cell lines and patient samples compared to SCLC counterparts.
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Description
Test your understanding of membrane transport concepts in this pre-class flashcard quiz for Biology 1610. Focus on the mechanisms of drug resistance in tumors and the role of ATP in active transport. Enhance your knowledge before class discussions.
