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Questions and Answers
What is the name of the peptide hormone involved in initiating puberty?
What is the name of the peptide hormone involved in initiating puberty?
What is the role of the granulosa cells in the developing follicle?
What is the role of the granulosa cells in the developing follicle?
What is the role of LH and FSH in the development of the oocyte?
What is the role of LH and FSH in the development of the oocyte?
What is the name of the stage in which the oogonia of the female fetus enter prophase of the first meiotic division?
What is the name of the stage in which the oogonia of the female fetus enter prophase of the first meiotic division?
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What is the number of primary follicles present at birth?
What is the number of primary follicles present at birth?
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What is the role of GnRH in the hypothalamic-pituitary-gonadal axis?
What is the role of GnRH in the hypothalamic-pituitary-gonadal axis?
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What happens to the primary follicles at the start of each ovarian cycle?
What happens to the primary follicles at the start of each ovarian cycle?
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What is the name of the structure formed by the surrounding stromal cells in the developing follicle?
What is the name of the structure formed by the surrounding stromal cells in the developing follicle?
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What is the role of human Chorionic Gonadotrophin (hCG) in maintaining pregnancy?
What is the role of human Chorionic Gonadotrophin (hCG) in maintaining pregnancy?
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What is the primary difference between the cervical mucus in the follicular and luteal phases of the menstrual cycle?
What is the primary difference between the cervical mucus in the follicular and luteal phases of the menstrual cycle?
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What hormone stimulates the development of primary follicles in the early follicular phase?
What hormone stimulates the development of primary follicles in the early follicular phase?
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Which of the following is NOT a target tissue effect of estrogens?
Which of the following is NOT a target tissue effect of estrogens?
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What hormone promotes the synthesis of progesterone and estradiol receptors in the uterine endometrium during the proliferative phase?
What hormone promotes the synthesis of progesterone and estradiol receptors in the uterine endometrium during the proliferative phase?
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Which of the following events directly triggers ovulation?
Which of the following events directly triggers ovulation?
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Where is testosterone produced and what stimulates its production?
Where is testosterone produced and what stimulates its production?
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How does the presence of the Sry gene in a male embryo influence steroid production?
How does the presence of the Sry gene in a male embryo influence steroid production?
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Which hormone is responsible for the changes in the endometrium necessary for implantation during the secretory phase?
Which hormone is responsible for the changes in the endometrium necessary for implantation during the secretory phase?
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What happens to granulosa cells in the follicle just before ovulation?
What happens to granulosa cells in the follicle just before ovulation?
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What is the main function of the corpus luteum?
What is the main function of the corpus luteum?
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What happens to FSH levels as follicles develop in the ovary?
What happens to FSH levels as follicles develop in the ovary?
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Which of the following hormones is directly involved in the degeneration of the corpus luteum?
Which of the following hormones is directly involved in the degeneration of the corpus luteum?
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What is the role of Sertoli cells in spermatogenesis?
What is the role of Sertoli cells in spermatogenesis?
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Which hormone is responsible for stimulating the Leydig cells in the testes?
Which hormone is responsible for stimulating the Leydig cells in the testes?
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What is the role of testosterone in spermatogenesis?
What is the role of testosterone in spermatogenesis?
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Which of the following is NOT a direct effect of testosterone?
Which of the following is NOT a direct effect of testosterone?
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What is the role of GnRH in the male reproductive system?
What is the role of GnRH in the male reproductive system?
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How does inhibin regulate the male reproductive system?
How does inhibin regulate the male reproductive system?
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What is the main reason why individuals with a deficiency in 5α-reductase have ambiguous external genitalia at birth?
What is the main reason why individuals with a deficiency in 5α-reductase have ambiguous external genitalia at birth?
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Which of the following statements accurately describes the development of germ cells in the testes?
Which of the following statements accurately describes the development of germ cells in the testes?
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What is the fluid-filled cavity that develops in a secondary follicle called?
What is the fluid-filled cavity that develops in a secondary follicle called?
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What is the structure that supports the ovum in the graafian follicle?
What is the structure that supports the ovum in the graafian follicle?
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What happens to the ruptured graafian follicle after ovulation?
What happens to the ruptured graafian follicle after ovulation?
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What is the name of the first half of the ovarian cycle?
What is the name of the first half of the ovarian cycle?
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What happens to the corpus luteum if fertilization does not occur?
What happens to the corpus luteum if fertilization does not occur?
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What is the role of GnRH?
What is the role of GnRH?
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Which hormone is responsible for stimulating ovulation?
Which hormone is responsible for stimulating ovulation?
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Which hormone(s) are responsible for inhibiting the release of FSH and LH?
Which hormone(s) are responsible for inhibiting the release of FSH and LH?
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Which of the following statements about steroid hormones is FALSE?
Which of the following statements about steroid hormones is FALSE?
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What is the primary function of hCG?
What is the primary function of hCG?
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What is the role of inhibin?
What is the role of inhibin?
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Which of the following BEST describes the role of LH in the production of steroid hormones in the ovary?
Which of the following BEST describes the role of LH in the production of steroid hormones in the ovary?
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Which of the following is NOT a characteristic of feedback mechanisms in hormone regulation?
Which of the following is NOT a characteristic of feedback mechanisms in hormone regulation?
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Flashcards
Graafian Follicle
Graafian Follicle
A mature ovarian follicle containing the ovum supported by cumulus oophorus in the antrum.
Corpus Luteum
Corpus Luteum
The structure formed from the ruptured graafian follicle, producing hormones in the luteal phase.
Ovarian Cycle Phases
Ovarian Cycle Phases
The ovarian cycle consists of two main phases: follicular phase and luteal phase, driven by hormone changes.
Corpus Albicans
Corpus Albicans
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Ovulation
Ovulation
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Steroid Hormones
Steroid Hormones
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Gonadal Hormones
Gonadal Hormones
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Kisspeptin
Kisspeptin
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GnRH
GnRH
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LH and FSH
LH and FSH
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Ovarian Cycle
Ovarian Cycle
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Primary Follicles
Primary Follicles
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Menstrual Cycle Hormones
Menstrual Cycle Hormones
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Aromatase function
Aromatase function
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Granulosa cells early cycle
Granulosa cells early cycle
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Follicular phase hormone action
Follicular phase hormone action
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LH spike effect
LH spike effect
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Corpus luteum function
Corpus luteum function
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LH level drop effect
LH level drop effect
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Endometrium after menstruation
Endometrium after menstruation
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Secretory phase maintenance
Secretory phase maintenance
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Feedback Mechanism
Feedback Mechanism
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Gonadotrophin
Gonadotrophin
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Gonadotrophin-Releasing Hormone (GnRH)
Gonadotrophin-Releasing Hormone (GnRH)
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Follicle Stimulating Hormone (FSH)
Follicle Stimulating Hormone (FSH)
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Leutenizing Hormone (LH)
Leutenizing Hormone (LH)
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Human Chorionic Gonadotropin (HCG)
Human Chorionic Gonadotropin (HCG)
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Estradiol
Estradiol
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Progesterone
Progesterone
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Testosterone Function
Testosterone Function
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Spermatogenesis
Spermatogenesis
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Role of Sertoli Cells
Role of Sertoli Cells
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Puberty Hormonal Sequence
Puberty Hormonal Sequence
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Functions of FSH
Functions of FSH
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Functions of LH
Functions of LH
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Effects of Testosterone
Effects of Testosterone
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5alpha-reductase Deficiency
5alpha-reductase Deficiency
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Cervical Mucus Changes
Cervical Mucus Changes
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Effects of Estrogens
Effects of Estrogens
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Testosterone Production
Testosterone Production
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In Utero Effects of Testosterone
In Utero Effects of Testosterone
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Study Notes
Biochemistry of Main Gonadal Hormones
- Learning Objectives: Recall precursor relationships of steroid hormones, outline the biochemical synthesis pathway of gonadal hormones and identify key enzymes, describe the hormonal inter-relationship in the control of female and male reproductive system (hypothalamic-pituitary-gonadal axis), outline the hormonal control of the normal female menstrual cycle, describe the actions of gonadal hormones, outline the role of pituitary gonadotropins in steroidogenesis in males and females, recognise defects of steroid hormone synthesis that cause abnormalities of sexual development.
- Ovarian Cycle - Follicular Changes: At weeks 11-12 of gestation, oogonia enter prophase of the first meiotic division and arrest. This forms the primary oocyte, with surrounding granulosa cells, forming primary follicles. No further development occurs until puberty. At birth, approximately 2 million primary follicles are present; by puberty, there are about 300,000.
Female
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Ovarian Cycle - Follicular Changes (cont.): At the start of each cycle, 10-20 primary follicles begin to develop. Follicular cells proliferate to form granulosa, and surrounding stromal cells form theca. Enlargement of the antrum (fluid-filled cavity) occurs, developing into the secondary follicle. The ovum is supported in the antrum on a stalk of cells called the cumulus oophorus, within the Graafian follicle.
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Ovulation: Around day 14, ovulation occurs: the Graafian follicle migrates to the surface of the ovary and ruptures, releasing the ovum. The cells of the ruptured follicle proliferate and develop into the corpus luteum ("yellow body"). The corpus luteum remains active for the second half of the cycle ("luteal phase"). If fertilization and implantation do not occur, the corpus luteum degenerates and is replaced by scar tissue (corpus albicans).
Ovarian Cycle - Hormonal Changes
- Hormonal Changes: The changes throughout the cycle are driven by the levels of various hormones. Feedback and feedforward mechanisms exist where one hormone controls the level of another.
Hormones in Male
- Hormones in Male: Testosterone is produced in Leydig cells under LH stimulation. The steroid synthesis pathway in testes produces testosterone (enzymes not available for other products). Testosterone is converted to DHT (a more potent androgen) by 5a-reductase in various tissues.
Spermatogenesis
- Spermatogenesis: Germ cells are laid down in the testes during fetal development, becoming spermatogonia. No further development occurs until puberty. In adolescence and adulthood, spermatogonia increase in number via mitosis. Spermatozoa are produced via meiosis. Sertoli cells in the testes secrete nutrients and growth factors for developing spermatogonia.
Puberty (Male and Female)
- Puberty (Male and Female): Kisspeptin increases GnRH, increasing LH and FSH from hypothalamus → puberty. FSH stimulates Sertoli cells, LH stimulates Leydig cells. The initiation of spermatogenesis requires both FSH and LH.
Hormonal Regulation Summary
- Hormonal control of both males and females involves a complex interplay between the hypothalamus and pituitary gland regulating gonadal hormone production. Negative and positive feedback loops exist, ensuring appropriate levels of hormones.
Target Tissue Effects (Males and Females)
- Estrogen Targets: Widening pelvis, breast development, maturation of genitalia, female pattern pubic hair, subcutaneous fat deposition, menstrual cycle, and ovulation.
- Androgen Targets: Foetal development of males, increased aggression and libido, enlargement of larynx, male pattern pubic hair, male physique, promotion of anabolic metabolism, beard growth, maturation of genitalia, sperm production.
Defects in Steroid Hormone Synthesis
- Defects: Inherited deficiency of 5 alpha-reductase prevents DHT synthesis from testosterone; leading to ambiguous external genitalia in affected boys. Congenital adrenal hyperplasia (CAH) is a deficiency in enzymes needed for corticosteroid synthesis, leading to overproduction of progestins/androgens and potentially life-threatening electrolyte imbalances and ambiguous genitalia in both sexes.
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Description
This quiz focuses on the biochemistry of main gonadal hormones and their synthesis pathways. It covers the hormonal control of the reproductive systems in both genders, detailing the ovarian cycle and the role of pituitary gonadotropins. Assess your understanding of key enzymes and defects in steroid hormone synthesis that can affect sexual development.