Biochemistry of Gonadal Hormones
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Questions and Answers

What is the name of the peptide hormone involved in initiating puberty?

  • Kisspeptin (correct)
  • GnRH
  • LH
  • FSH
  • What is the role of the granulosa cells in the developing follicle?

  • They produce estrogen. (correct)
  • They produce testosterone.
  • They form the theca interna and externa.
  • They produce progesterone.
  • What is the role of LH and FSH in the development of the oocyte?

  • They stimulate the release of progesterone.
  • They stimulate the development of the corpus luteum.
  • They stimulate the development of the follicle and the oocyte. (correct)
  • They stimulate ovulation.
  • What is the name of the stage in which the oogonia of the female fetus enter prophase of the first meiotic division?

    <p>Primary oocyte (A)</p> Signup and view all the answers

    What is the number of primary follicles present at birth?

    <p>2 million (C)</p> Signup and view all the answers

    What is the role of GnRH in the hypothalamic-pituitary-gonadal axis?

    <p>Stimulates the anterior pituitary to secrete LH and FSH. (C)</p> Signup and view all the answers

    What happens to the primary follicles at the start of each ovarian cycle?

    <p>10-20 of them begin to develop. (C)</p> Signup and view all the answers

    What is the name of the structure formed by the surrounding stromal cells in the developing follicle?

    <p>Theca interna (C), Theca externa (D)</p> Signup and view all the answers

    What is the role of human Chorionic Gonadotrophin (hCG) in maintaining pregnancy?

    <p>hCG stimulates the development of the corpus luteum, which produces progesterone. (C)</p> Signup and view all the answers

    What is the primary difference between the cervical mucus in the follicular and luteal phases of the menstrual cycle?

    <p>The mucus is thinner and more alkaline in the follicular phase, aiding sperm motility. (A)</p> Signup and view all the answers

    What hormone stimulates the development of primary follicles in the early follicular phase?

    <p>FSH (B)</p> Signup and view all the answers

    Which of the following is NOT a target tissue effect of estrogens?

    <p>Development of male secondary sex characteristics. (D)</p> Signup and view all the answers

    What hormone promotes the synthesis of progesterone and estradiol receptors in the uterine endometrium during the proliferative phase?

    <p>Estradiol (C)</p> Signup and view all the answers

    Which of the following events directly triggers ovulation?

    <p>Increased levels of LH (C)</p> Signup and view all the answers

    Where is testosterone produced and what stimulates its production?

    <p>Testosterone is produced in the Leydig cells of the testes and stimulated by LH. (C)</p> Signup and view all the answers

    How does the presence of the Sry gene in a male embryo influence steroid production?

    <p>It suppresses the expression of aromatase, resulting in testosterone production instead of estrogen. (A)</p> Signup and view all the answers

    Which hormone is responsible for the changes in the endometrium necessary for implantation during the secretory phase?

    <p>Progesterone (D)</p> Signup and view all the answers

    What happens to granulosa cells in the follicle just before ovulation?

    <p>They begin to produce progesterone (D)</p> Signup and view all the answers

    What is the main function of the corpus luteum?

    <p>Produce estradiol and progesterone (B)</p> Signup and view all the answers

    What happens to FSH levels as follicles develop in the ovary?

    <p>They decrease gradually (A)</p> Signup and view all the answers

    Which of the following hormones is directly involved in the degeneration of the corpus luteum?

    <p>LH (C)</p> Signup and view all the answers

    What is the role of Sertoli cells in spermatogenesis?

    <p>Nurturing developing spermatozoa (B)</p> Signup and view all the answers

    Which hormone is responsible for stimulating the Leydig cells in the testes?

    <p>LH (D)</p> Signup and view all the answers

    What is the role of testosterone in spermatogenesis?

    <p>Maintenance of spermatogenesis (D)</p> Signup and view all the answers

    Which of the following is NOT a direct effect of testosterone?

    <p>Stimulation of Sertoli cells (A)</p> Signup and view all the answers

    What is the role of GnRH in the male reproductive system?

    <p>Stimulate the pituitary gland to release LH and FSH (A)</p> Signup and view all the answers

    How does inhibin regulate the male reproductive system?

    <p>Inhibits the release of FSH (D)</p> Signup and view all the answers

    What is the main reason why individuals with a deficiency in 5α-reductase have ambiguous external genitalia at birth?

    <p>They cannot convert testosterone to DHT (A)</p> Signup and view all the answers

    Which of the following statements accurately describes the development of germ cells in the testes?

    <p>Spermatogonia are present at birth, but their development stalls until puberty (A)</p> Signup and view all the answers

    What is the fluid-filled cavity that develops in a secondary follicle called?

    <p>Antrum (A)</p> Signup and view all the answers

    What is the structure that supports the ovum in the graafian follicle?

    <p>Cumulus oophorus (D)</p> Signup and view all the answers

    What happens to the ruptured graafian follicle after ovulation?

    <p>It proliferates and develops into the corpus luteum. (D)</p> Signup and view all the answers

    What is the name of the first half of the ovarian cycle?

    <p>Follicular phase (D)</p> Signup and view all the answers

    What happens to the corpus luteum if fertilization does not occur?

    <p>It degenerates and becomes the corpus albicans. (A)</p> Signup and view all the answers

    What is the role of GnRH?

    <p>Stimulates the release of FSH and LH from the pituitary gland. (B)</p> Signup and view all the answers

    Which hormone is responsible for stimulating ovulation?

    <p>LH (A)</p> Signup and view all the answers

    Which hormone(s) are responsible for inhibiting the release of FSH and LH?

    <p>Both progesterone and estradiol (C)</p> Signup and view all the answers

    Which of the following statements about steroid hormones is FALSE?

    <p>Steroid hormones are produced by the pituitary gland. (D)</p> Signup and view all the answers

    What is the primary function of hCG?

    <p>Maintain the corpus luteum during pregnancy (C)</p> Signup and view all the answers

    What is the role of inhibin?

    <p>Inhibit the release of FSH and LH (C)</p> Signup and view all the answers

    Which of the following BEST describes the role of LH in the production of steroid hormones in the ovary?

    <p>LH stimulates theca cells to produce androgens, which are then converted to estradiol by granulosa cells. (B)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of feedback mechanisms in hormone regulation?

    <p>Feedback mechanisms are always initiated by a change in the level of a hormone. (C)</p> Signup and view all the answers

    Flashcards

    Graafian Follicle

    A mature ovarian follicle containing the ovum supported by cumulus oophorus in the antrum.

    Corpus Luteum

    The structure formed from the ruptured graafian follicle, producing hormones in the luteal phase.

    Ovarian Cycle Phases

    The ovarian cycle consists of two main phases: follicular phase and luteal phase, driven by hormone changes.

    Corpus Albicans

    Scar tissue replacing the corpus luteum if fertilization does not occur, known as the 'white body'.

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    Ovulation

    The release of the ovum from the graafian follicle around day 14 of the ovarian cycle.

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    Steroid Hormones

    Hormones derived from cholesterol involved in various body functions, especially reproduction.

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    Gonadal Hormones

    Hormones produced by the gonads (ovaries and testes) that regulate sexual development and reproduction.

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    Kisspeptin

    A peptide hormone that initiates puberty by stimulating GnRH secretion from the hypothalamus.

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    GnRH

    Gonadotropin-releasing hormone that triggers LH and FSH release from the anterior pituitary.

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    LH and FSH

    Luteinizing hormone and Follicle-stimulating hormone that regulate gonadal function.

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    Ovarian Cycle

    The series of events in the ovaries that lead to the maturation of eggs and the menstrual cycle.

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    Primary Follicles

    Immature ovarian structures that contain primary oocytes, present at birth and develop during the menstrual cycle.

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    Menstrual Cycle Hormones

    The hormones involved in regulating the menstrual cycle, including estrogen, progesterone, LH, and FSH.

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    Aromatase function

    Converts androgens to estrogens in granulosa cells.

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    Granulosa cells early cycle

    Do not have LH receptors and don't convert cholesterol to pregnenolone.

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    Follicular phase hormone action

    FSH stimulates follicle development and granulosa cell increase.

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    LH spike effect

    Trigger ovulation and development of LH receptors in granulosa cells.

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    Corpus luteum function

    Produces progesterone and estradiol after ovulation under LH stimulation.

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    LH level drop effect

    Leads to degeneration of corpus luteum and drop in steroid hormones.

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    Endometrium after menstruation

    Estradiol promotes repair and proliferation of uterine endometrium.

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    Secretory phase maintenance

    Depends on progesterone from corpus luteum; lack causes endometrium to slough off.

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    Feedback Mechanism

    A process where one hormone regulates another hormone's level.

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    Gonadotrophin

    Hormones like FSH and LH that stimulate reproductive functions.

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    Gonadotrophin-Releasing Hormone (GnRH)

    Hormone from hypothalamus that stimulates pituitary gonadotrophin release.

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    Follicle Stimulating Hormone (FSH)

    Produced by the pituitary; stimulates ovary for steroid and follicle maturation.

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    Leutenizing Hormone (LH)

    Pituitary hormone that triggers ovulation and maintains the corpus luteum.

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    Human Chorionic Gonadotropin (HCG)

    Produced by the placenta; maintains corpus luteum during pregnancy.

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    Estradiol

    A form of estrogen; inhibits LH and FSH release and supports follicle maturation.

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    Progesterone

    Hormone produced by corpus luteum; prepares the endometrium for implantation.

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    Testosterone Function

    Development of Wolffian duct into male reproductive structures.

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    Spermatogenesis

    Process of sperm production from spermatogonia, occurring in testes.

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    Role of Sertoli Cells

    Cells in testes providing nutrients and support for developing sperm.

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    Puberty Hormonal Sequence

    Kisspeptin stimulates GnRH, triggering LH and FSH release.

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    Functions of FSH

    Stimulates Sertoli cells for initiation of spermatogenesis.

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    Functions of LH

    Stimulates Leydig cells to produce testosterone.

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    Effects of Testosterone

    Mature male characteristics: aggression, libido, and body hair.

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    5alpha-reductase Deficiency

    Inherited condition leading to ambiguous genitalia due to DHT lack.

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    Cervical Mucus Changes

    Cervical mucus becomes less viscous and higher pH during the follicular phase, promoting sperm survival; more viscous and lower pH during the luteal phase, blocking sperm entry.

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    Effects of Estrogens

    Estrogens cause widening of the pelvis, breast development, maturation of genitalia, female pattern pubic hair, and subcutaneous fat deposition.

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    Testosterone Production

    Testosterone is produced in the Leydig cells of the testes under LH stimulation, primarily through a specific steroid synthesis pathway.

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    In Utero Effects of Testosterone

    The presence of Sry gene in male embryos suppresses estrogen production and leads to testosterone-driven male development.

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    Study Notes

    Biochemistry of Main Gonadal Hormones

    • Learning Objectives: Recall precursor relationships of steroid hormones, outline the biochemical synthesis pathway of gonadal hormones and identify key enzymes, describe the hormonal inter-relationship in the control of female and male reproductive system (hypothalamic-pituitary-gonadal axis), outline the hormonal control of the normal female menstrual cycle, describe the actions of gonadal hormones, outline the role of pituitary gonadotropins in steroidogenesis in males and females, recognise defects of steroid hormone synthesis that cause abnormalities of sexual development.
    • Ovarian Cycle - Follicular Changes: At weeks 11-12 of gestation, oogonia enter prophase of the first meiotic division and arrest. This forms the primary oocyte, with surrounding granulosa cells, forming primary follicles. No further development occurs until puberty. At birth, approximately 2 million primary follicles are present; by puberty, there are about 300,000.

    Female

    • Ovarian Cycle - Follicular Changes (cont.): At the start of each cycle, 10-20 primary follicles begin to develop. Follicular cells proliferate to form granulosa, and surrounding stromal cells form theca. Enlargement of the antrum (fluid-filled cavity) occurs, developing into the secondary follicle. The ovum is supported in the antrum on a stalk of cells called the cumulus oophorus, within the Graafian follicle.

    • Ovulation: Around day 14, ovulation occurs: the Graafian follicle migrates to the surface of the ovary and ruptures, releasing the ovum. The cells of the ruptured follicle proliferate and develop into the corpus luteum ("yellow body"). The corpus luteum remains active for the second half of the cycle ("luteal phase"). If fertilization and implantation do not occur, the corpus luteum degenerates and is replaced by scar tissue (corpus albicans).

    Ovarian Cycle - Hormonal Changes

    • Hormonal Changes: The changes throughout the cycle are driven by the levels of various hormones. Feedback and feedforward mechanisms exist where one hormone controls the level of another.

    Hormones in Male

    • Hormones in Male: Testosterone is produced in Leydig cells under LH stimulation. The steroid synthesis pathway in testes produces testosterone (enzymes not available for other products). Testosterone is converted to DHT (a more potent androgen) by 5a-reductase in various tissues.

    Spermatogenesis

    • Spermatogenesis: Germ cells are laid down in the testes during fetal development, becoming spermatogonia. No further development occurs until puberty. In adolescence and adulthood, spermatogonia increase in number via mitosis. Spermatozoa are produced via meiosis. Sertoli cells in the testes secrete nutrients and growth factors for developing spermatogonia.

    Puberty (Male and Female)

    • Puberty (Male and Female): Kisspeptin increases GnRH, increasing LH and FSH from hypothalamus → puberty. FSH stimulates Sertoli cells, LH stimulates Leydig cells. The initiation of spermatogenesis requires both FSH and LH.

    Hormonal Regulation Summary

    • Hormonal control of both males and females involves a complex interplay between the hypothalamus and pituitary gland regulating gonadal hormone production. Negative and positive feedback loops exist, ensuring appropriate levels of hormones.

    Target Tissue Effects (Males and Females)

    • Estrogen Targets: Widening pelvis, breast development, maturation of genitalia, female pattern pubic hair, subcutaneous fat deposition, menstrual cycle, and ovulation.
    • Androgen Targets: Foetal development of males, increased aggression and libido, enlargement of larynx, male pattern pubic hair, male physique, promotion of anabolic metabolism, beard growth, maturation of genitalia, sperm production.

    Defects in Steroid Hormone Synthesis

    • Defects: Inherited deficiency of 5 alpha-reductase prevents DHT synthesis from testosterone; leading to ambiguous external genitalia in affected boys. Congenital adrenal hyperplasia (CAH) is a deficiency in enzymes needed for corticosteroid synthesis, leading to overproduction of progestins/androgens and potentially life-threatening electrolyte imbalances and ambiguous genitalia in both sexes.

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    Description

    This quiz focuses on the biochemistry of main gonadal hormones and their synthesis pathways. It covers the hormonal control of the reproductive systems in both genders, detailing the ovarian cycle and the role of pituitary gonadotropins. Assess your understanding of key enzymes and defects in steroid hormone synthesis that can affect sexual development.

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