Biochemistry: Gluconeogenesis Pathway
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Questions and Answers

What is the primary role of the mitochondrial pyruvate transporter in the process described?

  • To export malate from the mitochondria to the cytosol
  • To transport pyruvate from the cytosol into the mitochondria (correct)
  • To convert pyruvate to oxaloacetate
  • To generate malate from oxaloacetate

    • What is the purpose of the reaction catalyzed by pyruvate carboxylase?

  • To generate NADH from mitochondrial NADH
  • To convert pyruvate to oxaloacetate (correct)
  • To transport malate from the mitochondria to the cytosol
  • To convert oxaloacetate to phosphoenolpyruvate

    • What is the purpose of the malate/α-ketoglutarate carrier in the process described?

  • To generate NADH from mitochondrial NADH
  • To convert oxaloacetate to phosphoenolpyruvate
  • To transport malate from the mitochondria to the cytosol (correct)
  • To transport pyruvate from the cytosol into the mitochondria

    • Which of the following is NOT a precursor for gluconeogenesis in the process described?

    <p>Glycerol (A)</p> Signup and view all the answers

    What is the purpose of the reaction catalyzed by phosphoenolpyruvate carboxykinase?

    <p>To convert oxaloacetate to phosphoenolpyruvate (C)</p> Signup and view all the answers

    Which of the following statements about gluconeogenesis is incorrect?

    <p>It is catalyzed by the same enzymes as glycolysis, but in the reverse direction. (B)</p> Signup and view all the answers

    Which of the following is not a key enzyme specific to gluconeogenesis?

    <p>Aldolase (B)</p> Signup and view all the answers

    In which of the following situations is gluconeogenesis required?

    <p>During prolonged starvation (B)</p> Signup and view all the answers

    What is the first bypass reaction in gluconeogenesis?

    <p>Conversion of pyruvate to phosphoenolpyruvate (C)</p> Signup and view all the answers

    Which of the following is not a reason for the continuous supply of glucose required by the body?

    <p>As a source of energy for adipose tissue (A)</p> Signup and view all the answers

    Flashcards

    Mitochondrial pyruvate transporter role?

    Transports pyruvate from the cytosol to the mitochondria.

    Pyruvate carboxylase function?

    Converts pyruvate to oxaloacetate.

    Malate/α-ketoglutarate carrier function?

    Moves malate out of the mitochondria to the cytosol.

    Gluconeogenesis precursor NOT glycerol?

    Glycerol isn't a gluconeogenesis precursor.

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    PEP carboxykinase function?

    Converts oxaloacetate to phosphoenolpyruvate.

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    Gluconeogenesis enzyme similarity to glycolysis?

    Gluconeogenesis uses different enzymes than glycolysis, not the same ones in reverse.

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    Gluconeogenesis-specific enzyme?

    Aldolase is NOT a gluconeogenesis-specific enzyme.

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    When is gluconeogenesis required?

    During prolonged starvation when glucose levels are low.

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    First gluconeogenesis bypass reaction?

    Conversion of pyruvate to phosphoenolpyruvate (PEP).

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    Glucose need - adipose tissue?

    Glucose isn't a primary energy source for adipose tissue.

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