Biochemistry: Gluconeogenesis Pathway

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Questions and Answers

What is the primary role of the mitochondrial pyruvate transporter in the process described?

  • To export malate from the mitochondria to the cytosol
  • To transport pyruvate from the cytosol into the mitochondria (correct)
  • To convert pyruvate to oxaloacetate
  • To generate malate from oxaloacetate

What is the purpose of the reaction catalyzed by pyruvate carboxylase?

  • To generate NADH from mitochondrial NADH
  • To convert pyruvate to oxaloacetate (correct)
  • To transport malate from the mitochondria to the cytosol
  • To convert oxaloacetate to phosphoenolpyruvate

What is the purpose of the malate/α-ketoglutarate carrier in the process described?

  • To generate NADH from mitochondrial NADH
  • To convert oxaloacetate to phosphoenolpyruvate
  • To transport malate from the mitochondria to the cytosol (correct)
  • To transport pyruvate from the cytosol into the mitochondria

Which of the following is NOT a precursor for gluconeogenesis in the process described?

<p>Glycerol (A)</p> Signup and view all the answers

What is the purpose of the reaction catalyzed by phosphoenolpyruvate carboxykinase?

<p>To convert oxaloacetate to phosphoenolpyruvate (C)</p> Signup and view all the answers

Which of the following statements about gluconeogenesis is incorrect?

<p>It is catalyzed by the same enzymes as glycolysis, but in the reverse direction. (B)</p> Signup and view all the answers

Which of the following is not a key enzyme specific to gluconeogenesis?

<p>Aldolase (B)</p> Signup and view all the answers

In which of the following situations is gluconeogenesis required?

<p>During prolonged starvation (B)</p> Signup and view all the answers

What is the first bypass reaction in gluconeogenesis?

<p>Conversion of pyruvate to phosphoenolpyruvate (C)</p> Signup and view all the answers

Which of the following is not a reason for the continuous supply of glucose required by the body?

<p>As a source of energy for adipose tissue (A)</p> Signup and view all the answers

Flashcards

Mitochondrial pyruvate transporter role?

Transports pyruvate from the cytosol to the mitochondria.

Pyruvate carboxylase function?

Converts pyruvate to oxaloacetate.

Malate/α-ketoglutarate carrier function?

Moves malate out of the mitochondria to the cytosol.

Gluconeogenesis precursor NOT glycerol?

Glycerol isn't a gluconeogenesis precursor.

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PEP carboxykinase function?

Converts oxaloacetate to phosphoenolpyruvate.

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Gluconeogenesis enzyme similarity to glycolysis?

Gluconeogenesis uses different enzymes than glycolysis, not the same ones in reverse.

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Gluconeogenesis-specific enzyme?

Aldolase is NOT a gluconeogenesis-specific enzyme.

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When is gluconeogenesis required?

During prolonged starvation when glucose levels are low.

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First gluconeogenesis bypass reaction?

Conversion of pyruvate to phosphoenolpyruvate (PEP).

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Glucose need - adipose tissue?

Glucose isn't a primary energy source for adipose tissue.

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