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Questions and Answers
What is the primary function of desmosine in elastin?
What is the primary function of desmosine in elastin?
Which protein provides a scaffold for elastin deposition?
Which protein provides a scaffold for elastin deposition?
What is the role of pyrophosphate in bone mineralization?
What is the role of pyrophosphate in bone mineralization?
Which type of bone is described as dense and provides structural support?
Which type of bone is described as dense and provides structural support?
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What is the primary function of osteoblasts in bone?
What is the primary function of osteoblasts in bone?
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Which disease is associated with defects in fibrillin?
Which disease is associated with defects in fibrillin?
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How is collagen organized within bone?
How is collagen organized within bone?
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What role does hydroxyapatite play in the composition of bone?
What role does hydroxyapatite play in the composition of bone?
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What condition is indicated by petechia on the lower extremities and gumline along with a super deficient platelet count?
What condition is indicated by petechia on the lower extremities and gumline along with a super deficient platelet count?
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What is the main difference between direct and indirect bilirubin?
What is the main difference between direct and indirect bilirubin?
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What is the role of estrogen in bone health?
What is the role of estrogen in bone health?
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How does calcium contribute to signal transduction?
How does calcium contribute to signal transduction?
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Which specimen type is NOT commonly used in clinical testing?
Which specimen type is NOT commonly used in clinical testing?
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What factor can have the largest impact on laboratory results?
What factor can have the largest impact on laboratory results?
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Which hormone is responsible for promoting calcium reabsorption in the kidneys?
Which hormone is responsible for promoting calcium reabsorption in the kidneys?
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What is NOT included in a basic metabolic panel?
What is NOT included in a basic metabolic panel?
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What triggers the release of parathyroid hormone (PTH)?
What triggers the release of parathyroid hormone (PTH)?
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Which of the following can occur if a patient eats before a fasting lab test?
Which of the following can occur if a patient eats before a fasting lab test?
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What role does calcium play in muscle contraction?
What role does calcium play in muscle contraction?
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Which cells are responsible for bone resorption?
Which cells are responsible for bone resorption?
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Which test is NOT part of liver function tests?
Which test is NOT part of liver function tests?
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What can imply a significant laboratory error due to sample collection issues?
What can imply a significant laboratory error due to sample collection issues?
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What effect does calcitonin have on calcium levels in the body?
What effect does calcitonin have on calcium levels in the body?
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Which factor is NOT associated with promoting osteoclastic activity?
Which factor is NOT associated with promoting osteoclastic activity?
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What is a common characteristic of oral precancerous lesions?
What is a common characteristic of oral precancerous lesions?
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Which of the following is considered a sign of advanced oral cancer?
Which of the following is considered a sign of advanced oral cancer?
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What appearance is most concerning for oral cancer?
What appearance is most concerning for oral cancer?
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What is considered the gold standard for diagnosing oral cancer?
What is considered the gold standard for diagnosing oral cancer?
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Which condition is a clear sign of hypophosphatasia?
Which condition is a clear sign of hypophosphatasia?
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Which alternative method is NOT scientifically backed for the diagnosis of oral lesions?
Which alternative method is NOT scientifically backed for the diagnosis of oral lesions?
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In which area of the mouth is there a higher concern for abnormalities indicative of oral cancer?
In which area of the mouth is there a higher concern for abnormalities indicative of oral cancer?
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What lesser-known condition can resemble oral cancer and is caused by friction?
What lesser-known condition can resemble oral cancer and is caused by friction?
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Which cells are primarily responsible for bone resorption?
Which cells are primarily responsible for bone resorption?
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What role do osteoblasts play in bone maintenance?
What role do osteoblasts play in bone maintenance?
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How does estrogen influence bone density in postmenopausal women?
How does estrogen influence bone density in postmenopausal women?
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Which process occurs on the pressure side of moving teeth during orthodontic treatment?
Which process occurs on the pressure side of moving teeth during orthodontic treatment?
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What is the primary component of enamel that contributes to its hardness?
What is the primary component of enamel that contributes to its hardness?
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What happens to bone density with age, particularly in women?
What happens to bone density with age, particularly in women?
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Which two factors are crucial for osteoclast differentiation?
Which two factors are crucial for osteoclast differentiation?
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What is one consequence of increased osteoclast activity in conditions like osteoporosis?
What is one consequence of increased osteoclast activity in conditions like osteoporosis?
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What is the primary component of plaque polysaccharides?
What is the primary component of plaque polysaccharides?
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What happens to the anaerobic environment within dental plaque as it develops?
What happens to the anaerobic environment within dental plaque as it develops?
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How does fluoride contribute to dental health?
How does fluoride contribute to dental health?
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Which of the following is a major type of oral cancer?
Which of the following is a major type of oral cancer?
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What are common risk factors for developing oral cancer?
What are common risk factors for developing oral cancer?
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At what sites is oral cancer typically found?
At what sites is oral cancer typically found?
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How does the access to oxygen change for bacteria in the interior of plaque?
How does the access to oxygen change for bacteria in the interior of plaque?
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Which statement accurately describes fluoride levels in nature?
Which statement accurately describes fluoride levels in nature?
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Flashcards
Thrombocytopenia
Thrombocytopenia
A condition where the platelet count is below the normal range.
Direct Bilirubin
Direct Bilirubin
Water-soluble bilirubin processed by the liver, ready for excretion.
Indirect Bilirubin
Indirect Bilirubin
Unconjugated, insoluble bilirubin, bound to albumin in the blood.
Pre-analytical variables
Pre-analytical variables
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Lipemia
Lipemia
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Hemolysis
Hemolysis
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Lipid Panel
Lipid Panel
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Basic Metabolic Panel (BMP)
Basic Metabolic Panel (BMP)
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Desmosine's role in elastin
Desmosine's role in elastin
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Elastin's structure
Elastin's structure
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Fibrillin's function
Fibrillin's function
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Bone composition
Bone composition
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Collagen's role in bone
Collagen's role in bone
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Hydroxyapatite's role in bone
Hydroxyapatite's role in bone
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Osteoblasts
Osteoblasts
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Osteons
Osteons
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Osteoblast function
Osteoblast function
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Osteoclast role
Osteoclast role
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RANKL and m-CSF
RANKL and m-CSF
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Bone resorption and remodeling
Bone resorption and remodeling
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Enamel composition
Enamel composition
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Bone Density and Age
Bone Density and Age
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Menopause and Osteoporosis
Menopause and Osteoporosis
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Bone loss in orthodontics
Bone loss in orthodontics
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Estrogen's effect on bone
Estrogen's effect on bone
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Calcium's role in signal transduction
Calcium's role in signal transduction
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Calcium's structural role
Calcium's structural role
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Calcium homeostasis
Calcium homeostasis
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Bone remodeling
Bone remodeling
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Parathyroid Hormone (PTH)
Parathyroid Hormone (PTH)
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Vitamin D role in Calcium Homeostasis
Vitamin D role in Calcium Homeostasis
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Osteoporosis's effect on teeth
Osteoporosis's effect on teeth
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Dental Plaque
Dental Plaque
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Anaerobic Microenvironment
Anaerobic Microenvironment
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Dextrans
Dextrans
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Fluoride's Role
Fluoride's Role
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Dental Calculus
Dental Calculus
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Squamous Cell Carcinoma
Squamous Cell Carcinoma
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Oral Cancer Risk Factors
Oral Cancer Risk Factors
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Oral Cancer Etiology
Oral Cancer Etiology
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Oral Precancer
Oral Precancer
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Leukoplakia
Leukoplakia
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Erythroplakia
Erythroplakia
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Hypophosphatemia
Hypophosphatemia
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Hypophosphatasia
Hypophosphatasia
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TNSALP
TNSALP
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Hydroxyapatite
Hydroxyapatite
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PPi (Pyrophosphate)
PPi (Pyrophosphate)
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Study Notes
Biochemistry Exam 3 Study Notes
-
Hemostasis and Blood Clotting:
- Clotting begins with platelet aggregation, triggered by contact with the sub endothelium, resulting in a prothrombotic response.
- Platelets are activated by collagen, thromboxane A2 (TXA2), and ADP.
- This process activates secondary messengers, IP3, leading to calcium release and platelet activation.
- Inactive platelets have receptors for PGI2, which antagonizes activation and inhibits calcium release.
- PGI2 and cyclic AMP decrease platelet aggregation, while TXA2 and ADP increase it.
- Blood clotting occurs through vasoconstriction, platelet plug formation (adhesion, activation, aggregation), and coagulation cascade.
- Blood clotting can be triggered by external or internal injury to the endothelial cell layer.
- Clotting factors (like II, VII, IX, X) rely on vitamin K (in their synthesis).
- Calcium plays a crucial role in the coagulation cascade.
- Inhibitors like antithrombin III and others help regulate clotting.
-
Roles of Calcium and Vitamin K:
- Clotting factors that bind calcium have modified amino acids.
- Vitamin K is a cofactor for the enzyme that carboxylates glutamic acid residues in clotting factors.
- These carboxylated residues are critical for binding calcium, an essential step in the clotting process.
- Citrate and EDTA are calcium chelators, that can block clotting.
-
Heme Biosynthesis:
- Heme is a prosthetic group found in hemoglobin and myoglobin.
- It's composed of a porphyrin ring with an iron ion (Fe2+) at the center.
- Critical steps of heme synthesis occur in mitochondria and cytoplasm.
- The synthesis pathway includes the formation of d-amino levulinic acid (d-ALA).
- The rate-limiting step in heme synthesis is the reaction catalyzed by d-ALA synthase.
- Enzymes like d-amino levulinic acid dehydratase and ferrochelatase are very sensitive to lead poisoning.
- Heme synthesis is regulated differently in liver and bone marrow. It can be regulated by feedback inhibition, by free heme, in the liver, through transcriptional and translational regulation of δ-aminolevulinate synthase. And in the bone marrow, heme synthesis is stimulated by erythropoietin and by iron.
-
Hemostasis Tests:
- PT (prothrombin time) tests the extrinsic pathway (factors VII, X,V).
- PTT (partial thromboplastin time) tests the intrinsic pathway (factors XII, XI, IX, VIII, X, V).
-
Blood Clotting Factors:
- Factors 8 and 9 are Vitamin K dependent.
- Factor Va is blocked by protein C in coagulation.
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Description
Prepare for your Biochemistry Exam 3 with this study guide focused on hemostasis and blood clotting mechanisms. Understand the roles of platelets, clotting factors, and the calcium-dependent cascade that leads to successful clot formation. Key concepts include the interaction of various molecules in the clotting process and the physiological responses to injury.