Biochemistry Chapter on Glycoproteins
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Questions and Answers

What is the primary function of glycoproteins in the cell?

  • Energy storage
  • Protein degradation
  • Water binding
  • Cell-surface recognition (correct)

Proteoglycans are primarily composed of proteins.

False (B)

What are the two types of carbohydrates mentioned in the content?

Starch and Glycogen

Glycoproteins are proteins with __________ covalently attached.

<p>oligosaccharides</p> Signup and view all the answers

Match the following structures with their descriptions:

<p>Proteoglycan = Negatively charged heteropolysaccharides associated with proteins Glycosaminoglycan = Water-binding gel-like matrix components Glycoprotein = Proteins with short carbohydrate chains attached Extracellular Matrix = Structural framework for cells</p> Signup and view all the answers

Which type of glycan is associated with blood group A?

<p>GalNAc (A)</p> Signup and view all the answers

The primary function of glycosaminoglycans is to provide lubricating properties to mucous secretions.

<p>True (A)</p> Signup and view all the answers

What is the most common posttranslational modification of proteins?

<p>Glycosylation</p> Signup and view all the answers

Which blood group is associated with the absence of both GalNAc and galactose?

<p>Blood group O (A)</p> Signup and view all the answers

Humans can digest cellulose efficiently due to specific enzymes.

<p>False (B)</p> Signup and view all the answers

What are the two main types of glycosidic bonds found in plant carbohydrates?

<p>Alpha and Beta glycosidic bonds</p> Signup and view all the answers

The enzyme that disrupts α(1->4) bonds in digestion is called ___(a), and it breaks down oligosaccharides and disaccharides into monosaccharides.

<p>α-amilase</p> Signup and view all the answers

Match the following transporters with their functions:

<p>SGLT-1 = Transport of glucose and galactose with sodium GLUT-5 = Transport of fructose GLUT-2 = Transport of monosaccharides from intestine to blood</p> Signup and view all the answers

Which of the following is not a classification of carbohydrates?

<p>Polypeptide (D)</p> Signup and view all the answers

A glycosidic bond occurs between two polysaccharides to form a disaccharide.

<p>False (B)</p> Signup and view all the answers

What is the general formula for carbohydrates?

<p>C(H2O)n</p> Signup and view all the answers

The simplest form of carbohydrates is called a ______.

<p>monosaccharide</p> Signup and view all the answers

Match the following types of carbohydrates with their characteristics:

<p>Monosaccharides = Simplest form of carbohydrates Disaccharides = Formed by two monosaccharides Polysaccharides = Long chains of monosaccharides Glycogen = Storage form of glucose in animals</p> Signup and view all the answers

Which of the following is an example of a structural polysaccharide?

<p>Cellulose (D)</p> Signup and view all the answers

Fructose and glucose have the same chemical formula but different structures.

<p>True (A)</p> Signup and view all the answers

What type of carbonyl group do aldoses contain?

<p>Aldehyde group</p> Signup and view all the answers

A ______ is formed when two monosaccharides are joined together.

<p>disaccharide</p> Signup and view all the answers

Which carbohydrate serves as a storage form in plants?

<p>Starch (A)</p> Signup and view all the answers

Flashcards

What are carbohydrates?

Carbohydrates are a group of carbonyl compounds (aldehydes or ketones) that contain several hydroxyl groups.

What are monosaccharides?

Monosaccharides are simple sugars that cannot be broken down further.

What are disaccharides?

Disaccharides are formed by the combination of two monosaccharides joined by a glycosidic bond.

What are polysaccharides?

Polysaccharides are long chains of monosaccharides linked together by glycosidic bonds.

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What are aldoses?

Aldoses are monosaccharides containing an aldehyde group.

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What are ketoses?

Ketoses are monosaccharides containing a ketone group.

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Name some common monosaccharides.

Glucose, fructose, and galactose are common examples of monosaccharides.

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Name some common disaccharides.

Sucrose, lactose, and maltose are common examples of disaccharides.

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Name some common polysaccharides.

Starch, glycogen, and cellulose are common examples of polysaccharides.

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What is the difference between glycogen and starch?

Glycogen is a storage polysaccharide in animals, while starch is a storage polysaccharide in plants.

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Starch

A type of polysaccharide that is made up of glucose molecules. It is found in plants and is a major source of energy for humans.

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Amylose

A linear chain of glucose molecules linked by alpha-1,4 glycosidic bonds. It is one of the two components of starch, the other being amylopectin.

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Amylopectin

A branched chain of glucose molecules linked by alpha-1,4 glycosidic bonds and alpha-1,6 glycosidic bonds. It is one of the two components of starch, the other being amylose.

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Proteoglycan

A type of complex molecule composed of a core protein and one or more glycosaminoglycan (GAG) chains. It forms a gel-like matrix in the extracellular space and is crucial for various biological functions.

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Glycosaminoglycans (GAGs)

Large, negatively charged, unbranched polysaccharide chains composed of repeating disaccharide units. They are a major component of proteoglycans and play a role in cell-cell interactions and tissue organization.

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Glycoprotein

A type of molecule that consists of a protein with one or more oligosaccharide chains (glycans) covalently attached to it. They are involved in a variety of cellular processes, including cell-cell recognition and cell signaling.

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Glycosylation

The process of adding a sugar molecule (glycan) to a protein. It is a common post-translational modification that is often found in secreted proteins.

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Mucin

A type of glycoprotein that is found in the extracellular matrix and plays a role in cell-cell interaction and tissue organization. It is characterized by its large size and its branched structure.

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Carbohydrate digestion

The breakdown of carbohydrates into simpler sugars and monosaccharides by enzymes like α-amylases and intestinal disaccharidases.

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Why humans can't digest cellulose

Human enzymes can only break down alpha glycosidic bonds, so we cannot digest cellulose (beta bonds).

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What is SGLT-1

The primary transporter in the intestine for glucose and galactose, which moves them into mucosal cells with sodium ions.

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Blood glucose regulation

The process of maintaining stable blood glucose levels, typically around 5mM, which is essential for brain function.

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What is hyperglycemia?

A condition where blood glucose levels remain above 8mM for an extended period, potentially causing damage to blood vessels.

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Study Notes

Carbohydrates Overview

  • Carbohydrates are a group of carbonyl compounds (aldehydes or ketones) that also contain several hydroxyl groups.
  • Carbohydrates have the general formula (CH₂O)ₙ.
  • Isomers have the same formula, but different structure.
  • Fructose and glucose have the formula C₆H₁₂O₆.

Carbohydrate Objectives

  • Recognize the general structure of carbohydrates
  • Classify carbohydrates
  • Recognize disaccharides
  • Recognize polysaccharides
  • Explain carbohydrate-modified protein structures and functions
  • Explain carbohydrate digestion

Carbohydrate Classification

  • Classification by number of units: monosaccharide, disaccharide, oligosaccharide, polysaccharide
  • "-ose" suffix is added to name monosaccharides.
  • Type of carbonyl group: aldose, ketose
  • Number of carbons: triose, tetrose, pentose, hexose, heptose, nonose

Important Monosaccharides Examples

  • Aldoses
    • 5 carbons: Aldopentose sugars (e.g., ribose, xylose)
    • 6 carbons: Aldohexose sugars (e.g., glucose, mannose)
  • Ketoses
    • 5 carbons: Ketopentose sugars (e.g., ribulose)
    • 6 carbons: Ketohexose sugars (e.g., fructose)

More Carbohydrate Information

  • Deoxyaldoses: A hydroxyl group (-OH) is missing in these sugars
  • Acetylated amino sugars: N-acetyl groups are added to the structure; examples include N-Acetyl-D-glucosamine (GlcNAc) and N-Acetyl-D-galactosamine (GalNAc)
  • Acidic monosaccharides: Contain carboxyl groups (-COOH); examples include D-glucuronic acid (GIcUA) and L-iduronic acid (IduUA).
  • Sugar alcohols (alditols): When an aldehyde group is oxidized, it becomes an alcohol; examples include D-sorbitol and D-mannitol.

Disaccharides

  • Two monosaccharides joined by a glycosidic bond.
  • Examples: maltose (glucose + glucose), lactose (galactose + glucose), sucrose (glucose + fructose).

Polysaccharides

  • Polymers of monosaccharides.
  • Examples:
    • Cellulose: Structural component in plants
    • Starch: Energy storage in plants
    • Glycogen: Energy storage in animals
    • Chitin: Structural component in fungi and exoskeletons of insects

Protein-Carbohydrate Structures

  • Carbohydrates can combine with proteins.
  • Proteoglycan: Negatively charged heteropolysaccharide (GAG) chains linked to a core protein.
  • Glycoproteins: Proteins with oligosaccharides attached.

Glycoprotein Functions

  • Cell-cell communication
  • Cell-surface recognition
  • Antigen display associated with blood types
  • Important for immune system reactions
  • Components of extracellular matrix (ECM)

Carbohydrate Digestion

  • Enzymes cleave glycosidic bonds.
  • Alpha-amylase in the mouth and intestines breaks down alpha glycosidic bonds in starch.
  • Humans lack enzymes that degrade beta glycosidic bonds in cellulose.

Carbohydrate Absorption

  • Monosaccharides (glucose, fructose, galactose) are absorbed from the small intestine into the bloodstream.
  • Different transport proteins (e.g., SGLT-1, GLUT-2, GLUT-5) are used for different monosaccharides.

Carbohydrate Metabolism

  • Blood glucose concentration is maintained around 5 mM (90 mg/dL).
  • Important for normal brain function.
  • Lower levels can lead to confusion, coma, and higher levels can lead to vascular damage.

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Description

Test your knowledge on glycoproteins and carbohydrates in this biochemistry quiz. Questions cover their functions, structures, and involvement in blood groups. Explore glycosaminoglycans and bond types to deepen your understanding.

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