Questions and Answers
Which disease is associated with the degradation of purine nucleotides?
Gout
What deficiency is associated with adenosine deaminase deficiency?
Immune deficiency
Which condition is related to orotic aciduria?
Genetic disorder
What type of drugs are used for treating cancer as mentioned in the text?
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What topic is covered in the text 'Biochemistry 11 Nucleotide metabolism'?
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Study Notes
Nucleotide Metabolism
- Purine nucleotides undergo degradation, a process crucial for maintaining cellular homeostasis
Diseases Associated with Purine Degradation
- Gout: a metabolic disorder caused by the accumulation of uric acid crystals in joints, resulting in inflammation and pain
- Adenosine deaminase deficiency: a genetic disorder that impairs the breakdown of adenosine, leading to severe combined immunodeficiency
Pyrimidine Metabolism
- Pyrimidine synthesis and degradation are critical processes in nucleic acid metabolism
- Pyrimidine synthesis occurs de novo, using aspartate, glutamine, and CO2 as precursors
- Pyrimidine degradation involves the breakdown of pyrimidine nucleotides to urea, CO2, and ammonia
Orotic Aciduria
- A rare genetic disorder characterized by the excretion of orotic acid in the urine
- Caused by a deficiency of the enzyme orotidylic acid decarboxylase
- Symptoms include megaloblastic anemia, intellectual disability, and cardiac problems
Antineoplastic Drugs
- Chemotherapeutic agents used to treat cancer by inhibiting nucleotide synthesis and degradation
- Examples include 5-fluorouracil, cytarabine, and gemcitabine, which target pyrimidine metabolism and DNA synthesis
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