Biochemical Mechanisms and Drug Interactions

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Questions and Answers

Qual es le function de le autoregulation in relation al NE release?

Es un systema pro regular le activity neuronale
Es un mechanism pro augmentar le release de NE
Es un modo de promover le excitatory response
Es un methodo pro inhibir le release de NE (correct)

Qual de le sequente es un effecto del sistema nervose simpatic?

Sedation
Central depression
Vasoconstriction (correct)
Vasodilation

Qual es le resultato de le binding del NE al receptor post-synaptic?

Activation del excitatory response (correct)
Inhibitor de la neurotransmission
Reduction del vascular tone
Inhibition del exocytosis

Qual es le relatio inter exocytosis e le post-synaptic response?

Exocytosis es essencial pro le excitatory response (C) Signup and view all the answers

Qual es un effecto impressente de le stimulation post-synaptic excitatory?

Augmentation del diastolic blood pressure (DBP) (C) Signup and view all the answers

Qual es le effecto principal de autoreceptores in neurones?

Inhibitorio (D) Signup and view all the answers

Qual parte del sistema nervose controla le function del nervo CN 7?

Craniosacral NS (C) Signup and view all the answers

Unde se trova le majority de receptores in un neurone?

Post-synapse (D) Signup and view all the answers

Qual nerve es responsabile pro le function craniosacral?

CN 10 (A) Signup and view all the answers

Qual es le principa function de enzimas in le systema nervose?

Medier le transmission del signal (B) Signup and view all the answers

Qual parte del systema nervose es associate con le nervo CN 3?

Craniosacral NS (C) Signup and view all the answers

Qual es le categoria del CN 9 in le systema nervose?

Mixed (A) Signup and view all the answers

Qual es le principal effecto de le systema thoracolumbar?

Excitar le reaction de lutto (A) Signup and view all the answers

Quale de istos representa un exemple de antagonista de purina?

Thioguanina (B) Signup and view all the answers

Quo es le resultato principal del meccanismo de contrafacimento in relation a DNA?

Bloca le synthese de DNA (D) Signup and view all the answers

Quale de le sequente es un antagonista de pirimidina?

5-fluorouracil (C) Signup and view all the answers

Quale de le sequente combina affinity e effector protectores?

Propranolol e NE (A) Signup and view all the answers

Quale affirmation describe le 'affinity' in le context de ligandos?

Le capacitate de un ligando de vincular se (C) Signup and view all the answers

Quo es le principale function de un antagonista?

Impedisce le action del ligando (A) Signup and view all the answers

Quo es un exemplo de un meccanismo que interfere le DNA?

Cytarabine (A) Signup and view all the answers

Quale anti-metabolite es un antagonista de purina?

Mercaptopurine (A) Signup and view all the answers

Qual es le function principale del ATPase in relation a caltion?

Extruder caltion (C) Signup and view all the answers

Qual enzyme es tote uno de los exemplares de catalysatores biologic?

MAO (Monoamine Oxidase) (C) Signup and view all the answers

Qual neurotransmittitor es associateva con le depressions major?

Norepinefrina (B), Serotonina (C) Signup and view all the answers

Qual es le effecto de MAOIs in relation a neurotransmittitores?

Augmentar le concentration de neurotransmittitores (B) Signup and view all the answers

Qual dopamine dysfunction es associateva con Parkinsonism?

Diminution de dopamina (A) Signup and view all the answers

Qual es le role importante del NAP in le cellular functions?

Manter le equilibre de ionos (B) Signup and view all the answers

Qual es un exemplo de un drug que inibisce le NAP?

Digoxin (C) Signup and view all the answers

Qual neurotransmittitore es non generalemente associateva con le metabolismo de MAO?

Glutamato (B) Signup and view all the answers

Qual es le resultado de le dysfunction de MAO en terminos de neurotransmittitors?

Incremento de catecholamines (A), Reduction de serotonina (C) Signup and view all the answers

Qual proteina es responsabile pro le contraction muscular?

Actina (A), Myosina (B) Signup and view all the answers

Quale substancia es considerata como un substrato pro reabsorption in iste contexte?

Hydralazine (B) Signup and view all the answers

Qual es le categoria del processo de reabsorption mentionate in le texto?

Saturabile (C) Signup and view all the answers

Qual methodo es relevante pro describer le reabsorption de Peni?

Michaelis-Menten (C) Signup and view all the answers

Quale de le sequente es un exemplo de droga sulfa?

Sulfamethoxazole (B) Signup and view all the answers

Quale statement es correcte riguardante le reabsorption de substanti?

Dependente de concentrati. (A) Signup and view all the answers

Study Notes

ATPase

Extrusion de cationes, especialmente calcio.
Enzymes functionanse como catalizadores biologicos: rapidece reactiones químicas.
Exemplo: MAO (Monoamine Oxidase) participa in metabolism de aminas biogenicas.

Metabolism de Aminas Biogenicas

MAO A et MAO B implicate in metabolism de norepinephrine (NE), epinephrine (Epi), e dopamine.
Disciplina de enfermedad major depression implica disalination de NE e serotonin (5-HT).
Parkinsonismo caracterizate per diminution de dopamine.

Medicamentos

Digoxin actua in contractilitate cardiaca.
MAOIs (Inhibitores de MAO) altere concentrasiones de aminas biogenicas.

Interferentia de Drugs

Interfere con DNA e metabolismo intermediarie.
Inibition de synthese de DNA mediante antimetabolites.
Exemples: Mercaptopurina, Thioguanine, 5-fluorouracil, Cytarabine.

Interacciones de Receptores de Medicamentos

Caracteristicas de receptores inclue afinidade de ligando, capace de vincular.
Diferente effectos de ligandos que targeta le stesso receptor, como NE versus Propranolol.
Substratos como Hydralazine e Isoniazid son saturabile e subjecte a Michaelis-Menten.

Neurones e Autoreceptores

Autoreceptores in neurones exercita effecto inhibitory, impede liberazione de neurotransmittedores.
Majority de receptores localizate in post-synapse.

Efectos Central e Peripherale

Efectos centrales incluyen sedativitate e depression.
Exocitosis e vasodilatation somma interacciones de neurotransmittedores.
Reuptake inhibition resulta in concentration elevate de neurotransmittedores in cleft synaptic.

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Description

Este quiz explora los mecanismos bioquímicos de las enfermedades, incluyendo el papel de MAO en el metabolismo de aminas biogénicas y la influencia de medicamentos en la interacción con receptores. También se abordan temas como la extrusión de cationes y la interferencia de drogas con el ADN. Comprender estos conceptos es crítico para el manejo de diversas condiciones médicas.