Biochemical Mechanisms and Drug Interactions
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Biochemical Mechanisms and Drug Interactions

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Questions and Answers

Qual es le function de le autoregulation in relation al NE release?

  • Es un systema pro regular le activity neuronale
  • Es un mechanism pro augmentar le release de NE
  • Es un modo de promover le excitatory response
  • Es un methodo pro inhibir le release de NE (correct)

    • Qual de le sequente es un effecto del sistema nervose simpatic?

  • Sedation
  • Central depression
  • Vasoconstriction (correct)
  • Vasodilation

    • Qual es le resultato de le binding del NE al receptor post-synaptic?

  • Activation del excitatory response (correct)
  • Inhibitor de la neurotransmission
  • Reduction del vascular tone
  • Inhibition del exocytosis

    • Qual es le relatio inter exocytosis e le post-synaptic response?

    <p>Exocytosis es essencial pro le excitatory response</p> Signup and view all the answers

    Qual es un effecto impressente de le stimulation post-synaptic excitatory?

    <p>Augmentation del diastolic blood pressure (DBP)</p> Signup and view all the answers

    Qual es le effecto principal de autoreceptores in neurones?

    <p>Inhibitorio</p> Signup and view all the answers

    Qual parte del sistema nervose controla le function del nervo CN 7?

    <p>Craniosacral NS</p> Signup and view all the answers

    Unde se trova le majority de receptores in un neurone?

    <p>Post-synapse</p> Signup and view all the answers

    Qual nerve es responsabile pro le function craniosacral?

    <p>CN 10</p> Signup and view all the answers

    Qual es le principa function de enzimas in le systema nervose?

    <p>Medier le transmission del signal</p> Signup and view all the answers

    Qual parte del systema nervose es associate con le nervo CN 3?

    <p>Craniosacral NS</p> Signup and view all the answers

    Qual es le categoria del CN 9 in le systema nervose?

    <p>Mixed</p> Signup and view all the answers

    Qual es le principal effecto de le systema thoracolumbar?

    <p>Excitar le reaction de lutto</p> Signup and view all the answers

    Quale de istos representa un exemple de antagonista de purina?

    <p>Thioguanina</p> Signup and view all the answers

    Quo es le resultato principal del meccanismo de contrafacimento in relation a DNA?

    <p>Bloca le synthese de DNA</p> Signup and view all the answers

    Quale de le sequente es un antagonista de pirimidina?

    <p>5-fluorouracil</p> Signup and view all the answers

    Quale de le sequente combina affinity e effector protectores?

    <p>Propranolol e NE</p> Signup and view all the answers

    Quale affirmation describe le 'affinity' in le context de ligandos?

    <p>Le capacitate de un ligando de vincular se</p> Signup and view all the answers

    Quo es le principale function de un antagonista?

    <p>Impedisce le action del ligando</p> Signup and view all the answers

    Quo es un exemplo de un meccanismo que interfere le DNA?

    <p>Cytarabine</p> Signup and view all the answers

    Quale anti-metabolite es un antagonista de purina?

    <p>Mercaptopurine</p> Signup and view all the answers

    Qual es le function principale del ATPase in relation a caltion?

    <p>Extruder caltion</p> Signup and view all the answers

    Qual enzyme es tote uno de los exemplares de catalysatores biologic?

    <p>MAO (Monoamine Oxidase)</p> Signup and view all the answers

    Qual neurotransmittitor es associateva con le depressions major?

    <p>Norepinefrina</p> Signup and view all the answers

    Qual es le effecto de MAOIs in relation a neurotransmittitores?

    <p>Augmentar le concentration de neurotransmittitores</p> Signup and view all the answers

    Qual dopamine dysfunction es associateva con Parkinsonism?

    <p>Diminution de dopamina</p> Signup and view all the answers

    Qual es le role importante del NAP in le cellular functions?

    <p>Manter le equilibre de ionos</p> Signup and view all the answers

    Qual es un exemplo de un drug que inibisce le NAP?

    <p>Digoxin</p> Signup and view all the answers

    Qual neurotransmittitore es non generalemente associateva con le metabolismo de MAO?

    <p>Glutamato</p> Signup and view all the answers

    Qual es le resultado de le dysfunction de MAO en terminos de neurotransmittitors?

    <p>Incremento de catecholamines</p> Signup and view all the answers

    Qual proteina es responsabile pro le contraction muscular?

    <p>Actina</p> Signup and view all the answers

    Quale substancia es considerata como un substrato pro reabsorption in iste contexte?

    <p>Hydralazine</p> Signup and view all the answers

    Qual es le categoria del processo de reabsorption mentionate in le texto?

    <p>Saturabile</p> Signup and view all the answers

    Qual methodo es relevante pro describer le reabsorption de Peni?

    <p>Michaelis-Menten</p> Signup and view all the answers

    Quale de le sequente es un exemplo de droga sulfa?

    <p>Sulfamethoxazole</p> Signup and view all the answers

    Quale statement es correcte riguardante le reabsorption de substanti?

    <p>Dependente de concentrati.</p> Signup and view all the answers

    Study Notes

    ATPase

    • Extrusion de cationes, especialmente calcio.
    • Enzymes functionanse como catalizadores biologicos: rapidece reactiones químicas.
    • Exemplo: MAO (Monoamine Oxidase) participa in metabolism de aminas biogenicas.

    Metabolism de Aminas Biogenicas

    • MAO A et MAO B implicate in metabolism de norepinephrine (NE), epinephrine (Epi), e dopamine.
    • Disciplina de enfermedad major depression implica disalination de NE e serotonin (5-HT).
    • Parkinsonismo caracterizate per diminution de dopamine.

    Medicamentos

    • Digoxin actua in contractilitate cardiaca.
    • MAOIs (Inhibitores de MAO) altere concentrasiones de aminas biogenicas.

    Interferentia de Drugs

    • Interfere con DNA e metabolismo intermediarie.
    • Inibition de synthese de DNA mediante antimetabolites.
    • Exemples: Mercaptopurina, Thioguanine, 5-fluorouracil, Cytarabine.

    Interacciones de Receptores de Medicamentos

    • Caracteristicas de receptores inclue afinidade de ligando, capace de vincular.
    • Diferente effectos de ligandos que targeta le stesso receptor, como NE versus Propranolol.
    • Substratos como Hydralazine e Isoniazid son saturabile e subjecte a Michaelis-Menten.

    Neurones e Autoreceptores

    • Autoreceptores in neurones exercita effecto inhibitory, impede liberazione de neurotransmittedores.
    • Majority de receptores localizate in post-synapse.

    Efectos Central e Peripherale

    • Efectos centrales incluyen sedativitate e depression.
    • Exocitosis e vasodilatation somma interacciones de neurotransmittedores.
    • Reuptake inhibition resulta in concentration elevate de neurotransmittedores in cleft synaptic.

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    Description

    Este quiz explora los mecanismos bioquímicos de las enfermedades, incluyendo el papel de MAO en el metabolismo de aminas biogénicas y la influencia de medicamentos en la interacción con receptores. También se abordan temas como la extrusión de cationes y la interferencia de drogas con el ADN. Comprender estos conceptos es crítico para el manejo de diversas condiciones médicas.

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