Biotech 8-Cell Cycle Regulation Part B

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Which of the following is NOT a key regulatory protein involved in cell cycle progression?

p53 (correct)

Rb

Cdk1

Cyclin B

Which cyclin-CDK complex operates at the G1/S transition?

Cyclin B/Cdk1

Cyclin E/Cdk2

Cyclin A/Cdk1

Cyclin D/Cdk4/6 (correct)

Which of the following is a CKI (cyclin-dependent kinase inhibitor)?

Cdk1

Cyclin B

Rb

p21 (correct)

Which proteins are phosphorylated in the active form of MPF (maturation-promoting factor)?

Cdc2 and Cyclin B Signup and view all the answers

What is the role of CDC25 in cell cycle regulation?

Promotes M phase Signup and view all the answers

How is MPF regulated?

All of the above Signup and view all the answers

Which of the following is true about the Rb protein?

It is a transcription factor Signup and view all the answers

Which of the following is true about p53?

It is a transcription factor Signup and view all the answers

Which CDK4/6 inhibitor is marketed by Pfizer?

Ibrance Signup and view all the answers

CDK4/6 inhibitors are usually administered in combination with hormone therapies to treat which type of breast cancer?

HR+ and HER2- Signup and view all the answers

What is the main function of MPF at M phase?

Regulation of MPF Signup and view all the answers

Which of the following is NOT a component of MPF?

Cyclin D Signup and view all the answers

What is the role of CKIs in the cell cycle?

Regulation of Cyclins and CDKs Signup and view all the answers

Which of the following is NOT involved in the regulation of Cyclin D / CDK4//6?

Drugs that target CDK4/6 Signup and view all the answers

What is the molecular basis of cell cycle regulation?

Studies in mammalian cells Signup and view all the answers

Which of the following is NOT a method used to study the history of the discovery of MPF?

Studies in yeast Signup and view all the answers

What are the substrates of Cdc2?

Cyclin B Signup and view all the answers

Which of the following is NOT a topic covered in the lectures on Biochemical foundations of pharmaceutical biotechnology?

Control of cell behavior A: Cell membrane and transport, drugs that impact cell transport Signup and view all the answers

Which cell types were used in the studies to understand the molecular mechanism of cell cycle regulation?

Frog (Xenopus) oocytes Signup and view all the answers

What is the name of the factor found in the cytoplasm of M phase cells that can cause G2 arrested cells to enter M phase?

MPF (Maturation Promoting Factor) Signup and view all the answers

Which genes were found to be important for progression from G1 to S in yeast?

Cdc28 (gene in Saccharomyces cerevisiae) and Cdc2 (gene in Saccharomyces pombe) Signup and view all the answers

What are the proteins encoded by certain genes that are required for yeast to pass through various phases of the cell cycle called?

cdcs Signup and view all the answers

What is the name of the proteins in sea urchin eggs that show a cyclic pattern throughout the cell cycle?

Cyclins Signup and view all the answers

What is the name of the phosphatase that dephosphorylates two of Cdc2's phospho-sites, activating MPF?

A phosphatase Signup and view all the answers

What is the role of Cdc2 (CDK1) in the cell cycle?

Phosphorylates substrates important for M phase Signup and view all the answers