28 Questions
Which of the following is NOT a key regulatory protein involved in cell cycle progression?
p53
Which cyclin-CDK complex operates at the G1/S transition?
Cyclin D/Cdk4/6
Which of the following is a CKI (cyclin-dependent kinase inhibitor)?
p21
Which proteins are phosphorylated in the active form of MPF (maturation-promoting factor)?
Cdc2 and Cyclin B
What is the role of CDC25 in cell cycle regulation?
Promotes M phase
How is MPF regulated?
All of the above
Which of the following is true about the Rb protein?
It is a transcription factor
Which of the following is true about p53?
It is a transcription factor
Which CDK4/6 inhibitor is marketed by Pfizer?
Ibrance
CDK4/6 inhibitors are usually administered in combination with hormone therapies to treat which type of breast cancer?
HR+ and HER2-
What is the main function of MPF at M phase?
Regulation of MPF
Which of the following is NOT a component of MPF?
Cyclin D
What is the role of CKIs in the cell cycle?
Regulation of Cyclins and CDKs
Which of the following is NOT involved in the regulation of Cyclin D / CDK4//6?
Drugs that target CDK4/6
What is the molecular basis of cell cycle regulation?
Studies in mammalian cells
Which of the following is NOT a method used to study the history of the discovery of MPF?
Studies in yeast
What are the substrates of Cdc2?
Cyclin B
Which of the following is NOT a topic covered in the lectures on Biochemical foundations of pharmaceutical biotechnology?
Control of cell behavior A: Cell membrane and transport, drugs that impact cell transport
Which cell types were used in the studies to understand the molecular mechanism of cell cycle regulation?
Frog (Xenopus) oocytes
What is the name of the factor found in the cytoplasm of M phase cells that can cause G2 arrested cells to enter M phase?
MPF (Maturation Promoting Factor)
Which genes were found to be important for progression from G1 to S in yeast?
Cdc28 (gene in Saccharomyces cerevisiae) and Cdc2 (gene in Saccharomyces pombe)
What are the proteins encoded by certain genes that are required for yeast to pass through various phases of the cell cycle called?
cdcs
What is the name of the proteins in sea urchin eggs that show a cyclic pattern throughout the cell cycle?
Cyclins
What is the name of the phosphatase that dephosphorylates two of Cdc2's phospho-sites, activating MPF?
A phosphatase
What is the role of Cdc2 (CDK1) in the cell cycle?
Phosphorylates substrates important for M phase
What happens when Cdc2 phosphorylates Cyclin B?
Cyclin B gets degraded
What are the substrates of Cdc2 (CDK1) in the cell cycle?
Nuclear lamins, Histone H1, MAPs
What are the two components of MPF from Xenopus?
A 34 kd protein and a 45 kd protein
Test your knowledge on the biochemical foundations of pharmaceutical biotechnology and cell cycle regulation. This quiz covers lectures 1-10, including topics such as the importance of biochemistry, molecular biology techniques, and drugs that target the cell cycle.
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