Podcast
Questions and Answers
Which factor does NOT affect the bioavailability of drugs?
Which factor does NOT affect the bioavailability of drugs?
- Lipophilicity
- Transporters
- Hydrophilicity
- Temperature (correct)
Which parameter is used to define the role of Transporters on bioavailability?
Which parameter is used to define the role of Transporters on bioavailability?
- Plasma concentration
- Clearance
- Area Under the Curve (AUC) (correct)
- Exposure
What is the significance of logP in drug absorption?
What is the significance of logP in drug absorption?
- It measures the drug's solubility in water
- It indicates the rate of drug metabolism
- It predicts the drug's permeability through biological membranes (correct)
- It reflects the drug's molecular weight
What is the relationship between AUC and Vd?
What is the relationship between AUC and Vd?
What is the primary parameter used to measure drug clearance?
What is the primary parameter used to measure drug clearance?
What is the ratio used to calculate the absolute bioavailability of a drug?
What is the ratio used to calculate the absolute bioavailability of a drug?
Which of the following best describes bioequivalence according to the US FDA?
Which of the following best describes bioequivalence according to the US FDA?
What is the primary factor used to assess clinically significant drug interactions?
What is the primary factor used to assess clinically significant drug interactions?
In relation to bioavailability, what does an absolute bioavailability of 1 (F=1) indicate?
In relation to bioavailability, what does an absolute bioavailability of 1 (F=1) indicate?
What is the purpose of comparing AUC values in relative bioavailability assessment?
What is the purpose of comparing AUC values in relative bioavailability assessment?
Which of the following routes of drug administration is NOT mentioned in the provided text?
Which of the following routes of drug administration is NOT mentioned in the provided text?
What is the primary factor affecting drug absorption mentioned in the text?
What is the primary factor affecting drug absorption mentioned in the text?
Which component is NOT mentioned as a part of the cell membrane in the provided text?
Which component is NOT mentioned as a part of the cell membrane in the provided text?
What type of barrier surrounds and contains the cytoplasm of a cell, as mentioned in the text?
What type of barrier surrounds and contains the cytoplasm of a cell, as mentioned in the text?
Which route of drug administration is specifically mentioned to avoid the First-Pass effect in the provided text?
Which route of drug administration is specifically mentioned to avoid the First-Pass effect in the provided text?
Which of the following is NOT a factor influencing drug transfer across cell membranes?
Which of the following is NOT a factor influencing drug transfer across cell membranes?
In which anatomical disposition do gaps between endothelial cells act as filters retaining large molecules?
In which anatomical disposition do gaps between endothelial cells act as filters retaining large molecules?
What is the primary role of fenestrated epithelium in endocrine glands in relation to drug transfer?
What is the primary role of fenestrated epithelium in endocrine glands in relation to drug transfer?
Which type of drug delivery to the site of action involves absorption, distribution, metabolism, and elimination in one compartment like the gut?
Which type of drug delivery to the site of action involves absorption, distribution, metabolism, and elimination in one compartment like the gut?
What is the driving force behind the process of aqueous diffusion across cell membranes?
What is the driving force behind the process of aqueous diffusion across cell membranes?
