Bioavailability and Drug Absorption
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Questions and Answers

Which factor does NOT affect the bioavailability of drugs?

  • Lipophilicity
  • Transporters
  • Hydrophilicity
  • Temperature (correct)
  • Which parameter is used to define the role of Transporters on bioavailability?

  • Plasma concentration
  • Clearance
  • Area Under the Curve (AUC) (correct)
  • Exposure
  • What is the significance of logP in drug absorption?

  • It measures the drug's solubility in water
  • It indicates the rate of drug metabolism
  • It predicts the drug's permeability through biological membranes (correct)
  • It reflects the drug's molecular weight
  • What is the relationship between AUC and Vd?

    <p>There is no direct relationship between AUC and Vd</p> Signup and view all the answers

    What is the primary parameter used to measure drug clearance?

    <p>Half-life (T1/2)</p> Signup and view all the answers

    What is the ratio used to calculate the absolute bioavailability of a drug?

    <p>AUC iv / AUC oral</p> Signup and view all the answers

    Which of the following best describes bioequivalence according to the US FDA?

    <p>Similar in-vivo performance with same active ingredient and dosage form</p> Signup and view all the answers

    What is the primary factor used to assess clinically significant drug interactions?

    <p>Peak plasma drug concentrations (Cmax)</p> Signup and view all the answers

    In relation to bioavailability, what does an absolute bioavailability of 1 (F=1) indicate?

    <p>Complete absorption</p> Signup and view all the answers

    What is the purpose of comparing AUC values in relative bioavailability assessment?

    <p>To assess bioequivalence with an established standard</p> Signup and view all the answers

    Which of the following routes of drug administration is NOT mentioned in the provided text?

    <p>Intravenous injection</p> Signup and view all the answers

    What is the primary factor affecting drug absorption mentioned in the text?

    <p>Lipophilicity</p> Signup and view all the answers

    Which component is NOT mentioned as a part of the cell membrane in the provided text?

    <p>Nucleic acids</p> Signup and view all the answers

    What type of barrier surrounds and contains the cytoplasm of a cell, as mentioned in the text?

    <p>Flexible barrier</p> Signup and view all the answers

    Which route of drug administration is specifically mentioned to avoid the First-Pass effect in the provided text?

    <p>Sub-lingual</p> Signup and view all the answers

    Which of the following is NOT a factor influencing drug transfer across cell membranes?

    <p>Concentration gradient</p> Signup and view all the answers

    In which anatomical disposition do gaps between endothelial cells act as filters retaining large molecules?

    <p>Vascular endothelium</p> Signup and view all the answers

    What is the primary role of fenestrated epithelium in endocrine glands in relation to drug transfer?

    <p>Facilitating the transfer of hormones to the bloodstream</p> Signup and view all the answers

    Which type of drug delivery to the site of action involves absorption, distribution, metabolism, and elimination in one compartment like the gut?

    <p>Direct application</p> Signup and view all the answers

    What is the driving force behind the process of aqueous diffusion across cell membranes?

    <p>Concentration gradient</p> Signup and view all the answers

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