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Questions and Answers
What does bioavailability provide an estimate of?
What does bioavailability provide an estimate of?
- The relative fraction of the administered dose that is absorbed into the systemic circulation (correct)
- The absolute fraction of the administered dose that is absorbed into the systemic circulation
- The concentration of the drug in the systemic circulation
- The total amount of unchanged drug that reaches the systemic circulation
How is bioavailability most often assessed for systemically available drug products?
How is bioavailability most often assessed for systemically available drug products?
- By assessing the volume of distribution of the drug
- By calculating the elimination rate constant of the drug
- By measuring the peak concentration of the drug in the plasma
- By determining the area under the drug plasma concentration-versus-time profile (AUC) (correct)
What does absolute bioavailability compare?
What does absolute bioavailability compare?
- The total amount of unchanged drug following different routes of administration
- The absolute concentration of the drug following different routes of administration
- The bioavailability of the active drug following intravenous administration with that following oral administration (correct)
- The bioavailability of different drugs within the systemic circulation
Why is intravenous drug administration considered 100% absorbed?
Why is intravenous drug administration considered 100% absorbed?
What route of administration is considered for extravascular administration in absolute bioavailability?
What route of administration is considered for extravascular administration in absolute bioavailability?
What does absolute bioavailability measure?
What does absolute bioavailability measure?
What is the absolute bioavailability of a drug given by the intravenous route?
What is the absolute bioavailability of a drug given by the intravenous route?
In a relative bioavailability study, what is compared?
In a relative bioavailability study, what is compared?
What is a multi-source drug product?
What is a multi-source drug product?
Why does it take years for innovator products to be released into the market?
Why does it take years for innovator products to be released into the market?
Which of the following is not a topic covered in the main course outline of Biopharmaceutics and Pharmacokinetics?
Which of the following is not a topic covered in the main course outline of Biopharmaceutics and Pharmacokinetics?
In the context of biopharmaceutics and pharmacokinetics, hepatic elimination refers to the:
In the context of biopharmaceutics and pharmacokinetics, hepatic elimination refers to the:
What type of study compares the bioavailability of a drug product to a reference standard, often the innovator product?
What type of study compares the bioavailability of a drug product to a reference standard, often the innovator product?
According to the course outline, which book would be a relevant reference for learning about controlled release medications?
According to the course outline, which book would be a relevant reference for learning about controlled release medications?
What does pharmacogenetics primarily focus on in the context of drug therapy?
What does pharmacogenetics primarily focus on in the context of drug therapy?
What does biopharmaceutics study?
What does biopharmaceutics study?
What does pharmacokinetics study?
What does pharmacokinetics study?
What is bioavailability defined as?
What is bioavailability defined as?
Where is the site of action usually located?
Where is the site of action usually located?
What is elimination defined as?
What is elimination defined as?
Study Notes
Bioavailability and Absorption
- Bioavailability provides an estimate of the fraction of an administered dose of a drug that reaches the systemic circulation.
- Bioavailability is most often assessed for systemically available drug products by comparing the area under the curve (AUC) of a drug concentration vs. time plot after administration via different routes.
Absolute Bioavailability
- Absolute bioavailability compares the bioavailability of a drug product administered via a non-intravenous route to the bioavailability of the same drug product administered via the intravenous route.
- Intravenous drug administration is considered 100% absorbed because the entire dose enters the systemic circulation directly.
- In absolute bioavailability, the extravascular route of administration is considered, such as oral, sublingual, or topical administration.
- Absolute bioavailability measures the fraction of the dose that reaches the systemic circulation after administration via a non-intravenous route.
Relative Bioavailability
- In a relative bioavailability study, the bioavailability of a drug product is compared to a reference standard, often the innovator product.
Biopharmaceutics and Pharmacokinetics
- A multi-source drug product is a product that is marketed by multiple manufacturers.
- Innovator products take years to be released into the market due to the need for extensive research, development, and regulatory approval.
- Hepatic elimination refers to the process by which the liver removes drugs from the bloodstream.
- Biopharmaceutics studies the relationship between the physical and chemical properties of a drug and its biological effects.
- Pharmacokinetics studies the movement of a drug within the body, including its absorption, distribution, metabolism, and elimination.
- Bioavailability is defined as the fraction of an administered dose of a drug that reaches the systemic circulation.
- The site of action is usually located at the target receptor or tissue where the drug exerts its therapeutic effect.
- Elimination is defined as the removal of a drug from the body, including processes such as metabolism, excretion, and transport.
Additional Topics
- Pharmacogenetics primarily focuses on the genetic factors that influence an individual's response to drug therapy.
- Controlled release medications are discussed in the book "Pharmaceutics: The Science of Dosage Form Design".
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Description
Test your knowledge of bioavailability and bioequivalence in pharmacokinetics through this lecture 11 quiz. Explore concepts such as relative and absolute availability, and the estimation of the fraction of the administered dose absorbed into the systemic circulation.
