Podcast
Questions and Answers
What are the two primary causes of bilirubinuria?
What are the two primary causes of bilirubinuria?
Obstruction of bile outflow and hepatocellular disease.
How can gallstones contribute to bilirubinuria?
How can gallstones contribute to bilirubinuria?
Gallstones can block the common bile duct, leading to obstruction of bile outflow.
What is the effect of acute viral hepatitis on bilirubin levels?
What is the effect of acute viral hepatitis on bilirubin levels?
Acute viral hepatitis may lead to an increase in bilirubin levels, often preceding symptoms like jaundice.
Which genetic conditions are associated with bilirubinuria?
Which genetic conditions are associated with bilirubinuria?
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Why is bilirubin not found in Gilbert's disease?
Why is bilirubin not found in Gilbert's disease?
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What is the significance of using diazotized 2,4-dichloroaniline in the Multistix urine test?
What is the significance of using diazotized 2,4-dichloroaniline in the Multistix urine test?
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How does the time required for color change differ between Multistix and Chemstrip tests?
How does the time required for color change differ between Multistix and Chemstrip tests?
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What factors might lead to false-negative results in bilirubin testing using these strips?
What factors might lead to false-negative results in bilirubin testing using these strips?
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How do large amounts of ascorbic acid affect the results of the urine bilirubin test?
How do large amounts of ascorbic acid affect the results of the urine bilirubin test?
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What is the impact of drug metabolites, such as those from phenazopyridine, on the test results?
What is the impact of drug metabolites, such as those from phenazopyridine, on the test results?
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What are the typical urine characteristics associated with bilirubinuria?
What are the typical urine characteristics associated with bilirubinuria?
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How does a positive test for urinary bilirubin and a negative test for urobilinogen help in diagnosis?
How does a positive test for urinary bilirubin and a negative test for urobilinogen help in diagnosis?
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What does the presence of pale-colored feces indicate in relation to bilirubin?
What does the presence of pale-colored feces indicate in relation to bilirubin?
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Explain the method by which the reagent strip detects bilirubin in urine.
Explain the method by which the reagent strip detects bilirubin in urine.
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Why is bilirubinuria not found with hemolytic jaundice?
Why is bilirubinuria not found with hemolytic jaundice?
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Study Notes
Bilirubinuria Test Methods
- Multistix uses diazotized 2,4-dichloroaniline as the diazo salt.
- Color change from cream-buff to tan at 20 seconds.
- Detects 0.8 mg per deciliter urine.
- Chemstrip uses 2,6-dichlorobezene; color changes from pink to violet at 30-60 seconds.
- Detects 0.5 mg per deciliter urine.
- Test must be fresh.
- Quickly hydrolyzes to less reactive form.
- Specimens exposed to light give false-negative results.
- Large amounts of ascorbic acid and nitrite lower bilirubin.
- Metabolites of drugs such as phenazopyridine (Pyridium) give a reddish color at low pH.
- Rifampin and large amounts of chlorpromazine mask the result.
- Salicylate metabolites do not interfere.
- Urobilinogen does not affect the result.
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Description
Explore the different methods used to test for bilirubinuria, focusing on the specifics of the Multistix and Chemstrip methods. This quiz covers essential details such as color changes, detection limits, and factors affecting the test results. Test your knowledge on this important aspect of urine analysis.
