Bile Storage and Release Mechanism

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Questions and Answers

What is the main function of the Sphincter of Oddi in relation to bile?

  • It contracts to prevent bile reflux into the gallbladder.
  • It reabsorbs bile acids in the ileum for recycling.
  • It relaxes to allow bile flow into the duodenum. (correct)
  • It secretes bicarbonate to neutralize bile acids.

Which process mainly occurs in the lumen of the small intestine for fat assimilation?

  • Formation of micelles conjugated with bile acids
  • Esterification to form triglycerides (correct)
  • Conjugation of secondary bile acids by colonic bacteria
  • Reabsorption of bile acids in the ileum

What happens to ~5% of conjugated bile acids in the enterohepatic circulation?

  • They are stored in the gallbladder.
  • They are broken down by pancreatic lipase.
  • They are reabsorbed in the jejunum.
  • They are lost in the feces. (correct)

Which molecule is responsible for delivering fat to tissues via lymphatics for utilization?

<p>Chylomicron (C)</p> Signup and view all the answers

How do bile acids mainly assist in the assimilation of fat?

<p>By forming micelles with fatty acids and monoglycerides. (A)</p> Signup and view all the answers

What is the primary function of the acinus in the liver?

<p>Bile acid synthesis (C)</p> Signup and view all the answers

Which amino acid is used for conjugation with primary bile acids in dogs?

<p>Taurine (D)</p> Signup and view all the answers

Which part of the gastrointestinal tract plays a significant role in reabsorbing 95% of conjugated bile acids?

<p>Ileum (B)</p> Signup and view all the answers

What is the rate-limiting step in the synthesis of primary bile acids?

<p>7-β hydroxylation (D)</p> Signup and view all the answers

Where are bile acids stored before being released into the intestine for digestion?

<p>Gallbladder (C)</p> Signup and view all the answers

Which species requires Taurine as an essential amino acid for bile acid conjugation?

<p>Cats (B)</p> Signup and view all the answers

What is the role of cholecystokinin (CCK) in gallbladder contraction?

<p>Mediates the contraction of the gallbladder (D)</p> Signup and view all the answers

In which species is the sphincter of Oddi less well-defined and constantly secreting bile into the intestinal tract?

<p>Ruminants (D)</p> Signup and view all the answers

What is a key difference in bile acid metabolism between dogs/cats and ruminants/pigs/horses?

<p>Ruminants/pigs/horses have a closed sphincter of Oddi between meals (D)</p> Signup and view all the answers

Which animal species does not have a gallbladder and has a weak sphincter of Oddi?

<p>Horses (C)</p> Signup and view all the answers

What is the significance of bile acids in systemic circulation for liver function?

<p>Increased bile acids in systemic circulation can signal impaired liver function (C)</p> Signup and view all the answers

What is the effect of special considerations like fasting on bile samples for liver function tests?

<p>Fasting can decrease bile production in horses, leading to unreliable results (A)</p> Signup and view all the answers

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