BI302 Lecture 7: Antibiotic Resistance Mechanisms

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the main focus of Lecture 7 on Antibiotic resistance in Microbiology Bacteriology?

  • Exploring the development of bacterial resistance to antibiotics (correct)
  • Minimizing the impact of antibiotic resistance
  • Understanding the mechanisms of antibiotic resistance
  • Investigating bacterial adaptation to environmental changes

Based on the information provided, what is a key takeaway message regarding E.coli in the MEGA plate experiment?

  • Mutant strains of E.coli developed innate resistance to antibiotics
  • E.coli had an inherent resistance to the antibiotic used in the experiment
  • Initial mutations in E.coli led to enhanced growth rates
  • Bacteria adapted to antibiotics exhibit normal growth rates (correct)

Which of the following best describes the concept of antibiotic resistance as mentioned in the text?

  • Antibiotic resistance leads to faster growth rates in bacteria
  • Microbes adapt to antibiotics by becoming more vulnerable
  • Antibiotic resistance renders previously susceptible microbes unaffected by antibiotics (correct)
  • A microbe's susceptibility to antibiotics remains constant over time

Which of the following is NOT mentioned as a mechanism by which bacteria develop resistance to antibiotics?

<p>Enhancing the efficacy of the antibiotic on bacteria (C)</p> Signup and view all the answers

What did the MEGA plate experiment reveal about bacterial adaptation to antibiotics?

<p>Fully resistant bacteria showed reduced growth rates (D)</p> Signup and view all the answers

According to CDC's 2019 report, how is antibiotic resistance defined?

<p>A microbe's susceptibility to antibiotics diminishes over time (D)</p> Signup and view all the answers

What does Resistance Transfer Factor (RTF) contain?

<p>Genes required for plasmid transfer (A)</p> Signup and view all the answers

How are Resistance (R) genes primarily transferred to other bacteria?

<p>Conjugation (B)</p> Signup and view all the answers

What distinguishes Conjugation from Transformation and Transduction?

<p>It requires direct cell-to-cell contact (C)</p> Signup and view all the answers

What happens to costly plasmids in the absence of selection pressure?

<p>They are purged from the population (A)</p> Signup and view all the answers

Which method involves bacteria taking up naked DNA fragments from their surroundings?

<p>Transformation (C)</p> Signup and view all the answers

'Fitness cost for plasmid retention' refers to:

<p>Energy consumption associated with retaining and replicating plasmids (A)</p> Signup and view all the answers

What is the process of transferring genetic information from a bacteriophage to a bacterium called?

<p>Generalised transduction (A)</p> Signup and view all the answers

Which bacterial species are mentioned in the text as naturally capable of uptaking whole plasmids?

<p>Bacillus (D)</p> Signup and view all the answers

What happens to DNA that is not integrated into the chromosome or a plasmid after being taken up by a bacterial cell?

<p>It is degraded by bacterial restriction enzymes (D)</p> Signup and view all the answers

Which type of transduction allows for an equal chance for any piece of the original bacteria's DNA to be packaged by the phage?

<p>Generalised transduction (B)</p> Signup and view all the answers

In the process of transduction, what might happen if the infected bacterial cell contains antibiotic resistance genes?

<p>The antibiotic resistance genes are packaged in a new phage and introduced to another bacterial cell (C)</p> Signup and view all the answers

What is the main function of enzymes produced by bacteria in relation to antibiotics?

<p>Generating resistance by degrading or modifying the antibiotic (A)</p> Signup and view all the answers

Which enzyme degrades penicillins and cephalosporins by hydrolysing the β-lactam ring?

<p>β-lactamases (B)</p> Signup and view all the answers

How do aminoglycoside-modifying enzymes affect antibiotics?

<p>Attaching chemical groups to the antibiotic's structure (B)</p> Signup and view all the answers

What contributes to B.subtilis being very resistant to ampicillin?

<p>Possession of a gene encoding β-lactamase (A)</p> Signup and view all the answers

How is the gene for β-lactamase transmitted among bacteria?

<p>Vertically from parent cell to progeny or horizontally between cells (D)</p> Signup and view all the answers

When may the effect of β-lactamase on bacteria be lost?

<p>If there is no selective pressure on the bacteria (B)</p> Signup and view all the answers

What is the main difference between antibiotic tolerance and antibiotic persistence as described in the text?

<p>Antibiotic tolerance refers to a population of bacteria without a resistance mechanism, while antibiotic persistence refers to persisters found within a susceptible population. (B)</p> Signup and view all the answers

In the context of minimizing the development of antibiotic resistance, why is it recommended to complete full courses of antibiotics?

<p>To reduce the likelihood of resistance acquisition by inhibiting or killing the entire pathogenic bacteria population. (D)</p> Signup and view all the answers

How does administering two or more drugs simultaneously help in reducing the likelihood of resistance acquisition?

<p>It creates a synergistic effect by targeting multiple bacterial components at once. (C)</p> Signup and view all the answers

How does limiting antibiotic use to essential cases help minimize antibiotic resistance development?

<p>It prevents the transfer of antibiotic resistance between non-pathogenic and pathogenic bacteria. (A)</p> Signup and view all the answers

What does MDK99.9 stand for in the context of bacterial survival mechanisms?

<p>Minimum duration for killing 99.9% of the population (D)</p> Signup and view all the answers

What is the purpose of targeting multiple bacterial components simultaneously with different drugs to reduce resistance?

<p>To reduce the likelihood of bacteria developing resistance through multiple mechanisms simultaneously. (B)</p> Signup and view all the answers

Flashcards are hidden until you start studying

More Like This

Use Quizgecko on...
Browser
Browser