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Questions and Answers
What does the law of Bergonie and Tribondeau primarily link together?
What does the law of Bergonie and Tribondeau primarily link together?
- Tumor aggression and metabolic rates
- Radiation dosage and patient age
- Cell proliferation and radiosensitivity (correct)
- Cell morphology and protein synthesis
Which type of tumors are stated to be highly susceptible to radiation according to the law of Bergonie and Tribondeau?
Which type of tumors are stated to be highly susceptible to radiation according to the law of Bergonie and Tribondeau?
- Tumors with predominantly necrotic cells
- Tumors of mature cell types
- Tumors with low mitotic rates
- Tumors composed of rapidly multiplying cells (correct)
In what year did Bergonie and Tribondeau publish their communication that laid down their law?
In what year did Bergonie and Tribondeau publish their communication that laid down their law?
- 1906 (correct)
- 1900
- 1925
- 1910
What inspired Bergonie and Tribondeau to formulate their law, according to recent analyses?
What inspired Bergonie and Tribondeau to formulate their law, according to recent analyses?
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What aspect of the relationship between radiosensitivity and cancer is emphasized in the content?
What aspect of the relationship between radiosensitivity and cancer is emphasized in the content?
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Study Notes
The Law of Bergonié and Tribondeau
- Rapidly dividing cells are highly sensitive to radiation, particularly those of embryonal origin and lymphoid tissues.
- The law states that radiosensitivity is directly correlated with cell proliferation rate, differentiation state, and mitotic activity.
- This law, established in 1906, is still recognized as a fundamental principle in radiation oncology.
- The law initially emphasized the link between proliferation and radiosensitivity, but has been debated regarding its accuracy.
- Recent studies suggest that observations by Claudius Regaud, a contemporary of Bergonié and Tribondeau, likely inspired the law.
Regaud's Influence
- Regaud, a pioneer in radiobiology, considered the law a "first approximation," implying limitations in its scope.
- Historical research has shown confusion between radiosensitivity and cancer susceptibility in early literature.
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