Questions and Answers
What is the therapeutic class of Benztropine?
What is the pharmacologic class of Benztropine?
Centrally acting cholinergic receptor blocker
Benztropine is effective at relieving tardive dyskinesia.
False
How does Benztropine act in the body?
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Benztropine is taken in divided doses, _ to _ times a day.
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What is the onset time for Benztropine when administered IM/IV?
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What are some common adverse effects of Benztropine?
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Which of the following is a contraindication for Benztropine?
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Benztropine can be safely combined with alcohol.
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What is the treatment for Benztropine overdose?
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Match the following drugs with their respective names:
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Study Notes
Benztropine Overview
- Benztropine, marketed as Cogentin, is classified as an antiparkinson drug and a centrally acting cholinergic receptor blocker.
Actions and Uses
- Blocks excess cholinergic stimulation in the corpus striatum.
- Relieves Parkinson's-like symptoms.
- Treats extrapyramidal symptoms (EPS) from antipsychotic medications.
- Effective in suppressing tremors but does not alleviate tardive dyskinesia.
Administration Alerts
- Patients may require assistance with self-administration.
- Can be dosed 2-4 times daily or as a single bedtime dose.
- Dosage reduction is necessary if muscle weakness occurs.
- Categorized as Pregnancy Category C.
Pharmacokinetics
- Onset of action is 15 minutes via IM/IV; 1 hour for PO administration.
- Peak effectiveness occurs within 1-2 hours.
- Duration of action lasts between 6-10 hours.
Adverse Effects
- Common anticholinergic side effects include dry mouth, constipation, and tachycardia.
- General adverse reactions may consist of sedation, drowsiness, dizziness, restlessness, irritability, nervousness, and insomnia.
Contraindications
- Not suitable for patients with narrow-angle glaucoma, myasthenia gravis, urinary tract blockage, severe dry mouth, hiatal hernia, severe constipation, enlarged prostate, or liver disease.
Drug-Drug Interactions
- Significant interactions with various medications, including aripiprazole, lorazepam, gabapentin, haloperidol, and others.
- Avoid combining with OTC cold medicines.
- Haloperidol may decrease benztropine's effectiveness, while other medications might enhance anticholinergic effects.
- Alcohol is contraindicated due to increased sedative effects.
Treatment of Overdose
- Physostigmine (1-2 mg subcutaneously or IV) can reverse anticholinergic intoxication symptoms; a second dose may be given after 2 hours if needed.
- Other treatment is general and supportive.
Other Drugs in Class
- Similar medications include biperiden (Akineton), diphenhydramine (Benadryl), and trihexyphenidyl (Artane).
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Description
This quiz covers the essential information about Benztropine, including its actions, uses, pharmacokinetics, and administration alerts. Understand how this medication helps alleviate symptoms related to Parkinson's disease and the adverse effects associated with its use.
