Benign vs Malignant Tumors: Key Concepts

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Questions and Answers

What laboratory test is used to determine the presence of inflammation?

  • C-reactive protein (CRP) (correct)
  • Complete blood count (CBC) with differential
  • Blood glucose test
  • Erythrocyte sedimentation rate (ESR)

Which of the following is NOT a cardinal sign of inflammation?

  • Redness (rubor)
  • Edema (tumor)
  • Weight gain (correct)
  • Pain (dolor)

Which electrolyte is primarily regulated by the kidneys and is crucial for heart function?

  • Potassium (K+) (correct)
  • Magnesium (Mg+)
  • Calcium (Ca+)
  • Sodium (Na+)

What systemic response is commonly associated with acute inflammation?

<p>Lymphadenopathy (D)</p> Signup and view all the answers

What is the range of normal Sodium (Na+) levels in mEq/L?

<p>135-145 (D)</p> Signup and view all the answers

What characterizes benign tumors?

<p>They resemble the tissue of origin and remain localized. (C)</p> Signup and view all the answers

Which statement accurately reflects the growth rate of malignant tumors?

<p>They have an erratic growth rate, which can be slow or fast. (B)</p> Signup and view all the answers

In the context of apoptosis, what implication does failure in this process have?

<p>It can lead to the development of certain cancers and tumors. (C)</p> Signup and view all the answers

How does excessive apoptosis affect cellular health?

<p>It is associated with excessive cell death rates. (B)</p> Signup and view all the answers

What is a characteristic of malignant tumors in relation to metastasis?

<p>They may metastasize via blood or lymphatic routes. (B)</p> Signup and view all the answers

Which stage indicates that a malignant tumor has metastasized?

<p>Stage IV: metastasized to another area (B)</p> Signup and view all the answers

What describes how benign tumors interact with surrounding tissues?

<p>They stay cohesive and well-demarcated. (C)</p> Signup and view all the answers

In the context of tumor differentiation, what best describes malignant tumors?

<p>They range from well-differentiated to poorly differentiated. (B)</p> Signup and view all the answers

What occurs in metabolic acidosis when pH levels are too low?

<p>The respiratory center increases respirations to blow off CO2 (B)</p> Signup and view all the answers

Which of the following indicates complete compensation in a metabolic disturbance?

<p>pH is normal and both CO2 and HCO3 are abnormal (A)</p> Signup and view all the answers

In diabetic insipidus, which of the following is a primary risk factor for patients?

<p>Hypernatremia causing seizures (D)</p> Signup and view all the answers

What is the threshold for hyponatremia in terms of sodium levels?

<p>Less than 135 mEq/L (B)</p> Signup and view all the answers

What physiological action do the kidneys take during respiratory alkalosis compensation?

<p>Excrete maximum HCO3 and retain H+ (C)</p> Signup and view all the answers

What dietary recommendation is made for patients with hypertension and heart failure concerning sodium intake?

<p>Limit sodium to 1,500 mg or fewer per day (C)</p> Signup and view all the answers

What symptom is NOT typically associated with hyponatremia?

<p>Excessive urination (D)</p> Signup and view all the answers

During metabolic alkalosis, what response occurs in the lungs?

<p>Decrease ventilation to retain CO2 (D)</p> Signup and view all the answers

What is the primary role of T lymphocytes that mature in the thymus?

<p>Identifying and fighting off foreign invaders (A)</p> Signup and view all the answers

What distinguishes primary lymphoid tissue from secondary lymphoid tissue?

<p>Primary lymphoid tissue is where lymphocytes are produced, while secondary lymphoid tissue is where they activate. (D)</p> Signup and view all the answers

What occurs in the spleen during the breakdown of red blood cells?

<p>Old, hemolyzed RBCs are isolated and destroyed (A)</p> Signup and view all the answers

Which statement describes the initial response of the body to stress?

<p>Hormones like adrenaline prepare the body for immediate action. (A)</p> Signup and view all the answers

What specific function do the lymph nodes serve in the immune system?

<p>They filter lymph fluid of pathogens and the debris. (B)</p> Signup and view all the answers

What is splenomegaly indicative of within the body's function?

<p>Excessive breakdown of red blood cells (B)</p> Signup and view all the answers

Where do immature T lymphocytes mature before being released into circulation?

<p>Thymus (C)</p> Signup and view all the answers

What hormone triggers the pituitary gland to release ACTH during the stress response?

<p>Corticotropin-releasing hormone (CRH) (C)</p> Signup and view all the answers

What is the primary cause of liver inflammation in Hepatitis A?

<p>Immune system response (B)</p> Signup and view all the answers

Which factor would NOT typically indicate a need for prenatal genetic screening?

<p>Regular exercise routine (B)</p> Signup and view all the answers

How long after conception is Chorionic Villus Sampling (CVS) performed?

<p>10 to 12 weeks (D)</p> Signup and view all the answers

Which of the following is a characteristic of Aortic Sclerosis?

<p>Arteriosclerotic calcification of heart valves (C)</p> Signup and view all the answers

What does passive diffusion involve?

<p>Movement of particles from high to low concentration (D)</p> Signup and view all the answers

What is the main purpose of genetic screening for individuals with a family history of breast cancer?

<p>To understand potential inherited risks (D)</p> Signup and view all the answers

Which test is most accurate for diagnosing an aortic valve condition?

<p>Ultrasound (D)</p> Signup and view all the answers

Which of the following is NOT a potential method for evaluating baby's health during pregnancy?

<p>Physical examination at birth (B)</p> Signup and view all the answers

Which condition is characterized by an abnormal accumulation of acids or an abnormal loss of bases?

<p>Metabolic acidosis (C)</p> Signup and view all the answers

In which condition would you expect to find a blood pH greater than 7.45 as a primary lab result?

<p>Respiratory alkalosis (D)</p> Signup and view all the answers

What is the expected change in PCO2 during respiratory alkalosis?

<p>PCO2 &lt; 35 mm Hg (B)</p> Signup and view all the answers

Which symptom is likely to be seen in a patient experiencing metabolic acidosis?

<p>Kussmaul's breathing (B)</p> Signup and view all the answers

What would be the compensatory mechanism of the kidneys in metabolic alkalosis?

<p>Excrete H+ (B)</p> Signup and view all the answers

Which of the following conditions is most directly associated with elevated bicarb levels?

<p>Metabolic alkalosis (D)</p> Signup and view all the answers

Which lab finding is indicative of respiratory acidosis?

<p>PCO2 &gt; 45 mm Hg (D)</p> Signup and view all the answers

In metabolic acidosis, which of the following could be a cause?

<p>Diarrhea with loss of bicarb (D)</p> Signup and view all the answers

What physiological change would be expected in a patient experiencing hypocapnia?

<p>Increased blood pH (C)</p> Signup and view all the answers

What is a common clinical manifestation of respiratory acidosis?

<p>Cyanosis (B)</p> Signup and view all the answers

How do the kidneys compensate during respiratory acidosis?

<p>Reabsorb HCO3- (D)</p> Signup and view all the answers

What lab result would indicate a state of acidosis?

<p>pH &lt; 7.35 (C)</p> Signup and view all the answers

What is typically true regarding metabolic alkalosis compensation?

<p>Lungs decrease respiration to hold CO2 (B)</p> Signup and view all the answers

Which condition may lead to respiratory acidosis due to muscle weakness?

<p>COPD (C)</p> Signup and view all the answers

Flashcards

Apoptosis

A type of cell death that is programmed and controlled by our genes.

Differentiation

The process of cells becoming more specialized and acquiring specialized functions during development.

Benign Tumor

A tumor that is confined to its original location and does not spread to other parts of the body.

Malignant Tumor

A tumor that can invade surrounding tissues and spread to other parts of the body.

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Metastasis

The spread of cancer cells from the original tumor to other parts of the body.

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Dedifferentiation

A process where the cells in a tumor lose their specialized characteristics and become more similar to primitive cells.

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Proliferation

The process of cell division and multiplication.

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Hyperplasia

A condition characterized by an abnormal increase in the number of cells in a tissue or organ.

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Cardinal Signs of Inflammation (RHELP)

A group of symptoms commonly associated with inflammation, including redness, heat, swelling, pain and loss of function.

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Hypertension and Cortisol

High levels of cortisol, a hormone produced by the adrenal glands, can lead to high blood pressure.

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C-reactive Protein (CRP)

A blood test that measures the amount of C-reactive protein in the blood. Elevated levels indicate inflammation.

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Erythrocyte Sedimentation Rate (ESR)

A blood test which measures the sedimentation rate of red blood cells. Increased ESR suggests inflammation.

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Anemia in Inflammation

A decrease in the number of red blood cells, often a consequence of inflammation.

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Metabolic Acidosis

A state where the body's pH is too low (acidic) due to an imbalance in the body's acid-base balance.

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Metabolic Alkalosis

A state where the body's pH is too high (alkaline) due to an imbalance in the body's acid-base balance.

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Respiratory Acidosis

A condition where the body's pH is too low (acidic) due to problems with the respiratory system (lungs).

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Respiratory Alkalosis

A condition where the body's pH is too high (alkaline) due to problems with the respiratory system (lungs).

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Compensation (Acid-Base)

The process by which the body tries to correct an acid-base imbalance.

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Hyponatremia

A condition characterized by a low blood sodium level (below 135 mEq/L).

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Diabetes Insipidus

A condition where the body cannot regulate water balance due to a lack of antidiuretic hormone (ADH) or the kidneys' inability to respond to it.

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Polyarthritis

A condition characterized by the simultaneous involvement of five or more joints in the body by arthritis.

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Granuloma

A structure formed by the immune system to contain and isolate foreign substances that cannot be easily removed. It typically contains lymphocytes, fibroblasts, and connective tissue.

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T cells

Mature T lymphocytes (T cells) produced and developed in the thymus gland. They are crucial for recognizing and fighting off foreign invaders in the immune system.

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Thymus

The gland where T cells mature and learn to distinguish between self and foreign cells. Located in the mediastinum, it protects immature T cells from blood antigens.

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Primary Lymphoid Tissue

Primary lymphoid tissues are responsible for generating immune cells. Bone marrow produces all blood cells, including B cells, while the thymus matures T cells.

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Secondary Lymphoid Tissue

Secondary lymphoid tissues are the sites where immune responses are initiated and carried out. Lymph nodes filter bacteria, the spleen stores immune cells, and lymphoid tissues like tonsils protect membranes.

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Spleen

A highly vascular organ responsible for removing aged and damaged red blood cells from circulation, playing a role in both immunity and red blood cell breakdown.

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Alarm Stage of Stress

The body's initial response to stress, characterized by the release of hormones like adrenaline and cortisol, preparing the body for 'fight or flight'.

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Sympathetic Nervous System

The part of the autonomic nervous system that controls the 'fight or flight' response, releasing norepinephrine to increase heart rate and blood pressure.

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Hepatitis A

A highly contagious liver infection caused by a virus, often spread through contaminated food or water, or contact with an infected person.

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Atherosclerosis

A condition characterized by narrowed arteries due to a buildup of plaque, often initiated by high blood sugar and inflammation.

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Histological Examination of Lymph Nodes

A type of blood test that analyzes the cells in lymph nodes to determine the stage of breast cancer based on its spread.

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Percutaneous Umbilical Cord Blood Sampling (PUBS)

Taking a sample of blood from the umbilical cord to test the baby's health and diagnose genetic disorders before birth.

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Aortic Valve Diagnosis

A test used to diagnose aortic valve problems, especially in conjunction with ultrasound.

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Aortic Sclerosis

Calcification of the heart valves due to aging, contributing to hardening of the arteries.

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Passive Diffusion

Movement of particles from an area of high concentration to low concentration without requiring energy.

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Chorionic Villus Sampling (CVS)

A type of prenatal screening that involves taking a sample of tissue from the placenta to test for genetic abnormalities.

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Hypoglycemia

A condition of low blood sugar levels, usually below 70 mg/dL. This occurs when the body cannot properly regulate blood glucose.

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Diabetic Ketoacidosis (DKA)

A serious complication of diabetes characterized by high blood glucose, dehydration, and an accumulation of ketones in the blood.

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Hyperosmolar Hyperglycemic State (HHS)

A condition associated with high blood glucose levels but without the presence of ketones.

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Partial Pressure of Carbon Dioxide (PCO2)

A measurement of the amount of carbon dioxide (CO2) in the blood.

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Bicarbonate (HCO3-)

A measurement of the amount of bicarbonate (HCO3-) in the blood, which is a base that helps regulate blood pH.

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Compensation

A process by which the body compensates for an acid-base imbalance in one system by adjusting the other system.

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Kussmaul's Breathing

A type of breathing characterized by deep, rapid breaths, often seen in metabolic acidosis.

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Labored Breathing

A type of breathing characterized by shallow or labored breaths, often seen in respiratory acidosis.

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Acidosis

A decrease in the normal pH of the blood, indicating acidosis.

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Alkalosis

An increase in the normal pH of the blood, indicating alkalosis.

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Breathing

The process of inhaling oxygen and exhaling carbon dioxide via the lungs.

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pH

A measurement of the acidity or alkalinity of a solution, a measure of hydrogen ion (H+) concentration.

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Study Notes

Benign versus Malignant Tumors

  • Benign tumors resemble the tissue of origin

  • Grow progressively slowly

  • Remain localized; cohesive cells

  • Not invasive; do not destroy surrounding tissue

  • Do not break away from the tumor cell mass

  • No metastasis

  • Malignant tumors range from well-differentiated to poorly differentiated

  • Poorly differentiated do not resemble tissue of origin

  • Grow erratically; faster than benign tumors

  • Invasive and destructive to surrounding tissue

  • Lack adhesion; easily travel to distant sites via metastasis

  • Common locations for metastasis include the lymphatic system or bloodstream

Staging of Malignant Tumors

  • Stage I: localized
  • Stage II: early locally advanced
  • Stage III: late locally advanced
  • Stage IV: metastasized

Apoptosis

  • Genetically programmed cell death
  • Example in ovaries during menopause
  • Example in WBCs after inflammatory reaction
  • Failure in apoptosis can lead to cancer or tumors
  • Excessive apoptosis can lead to excessive cell death

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