Podcast
Questions and Answers
What is the main mechanism by which bacteria become resistant to beta-lactam antibiotics?
What is the main mechanism by which bacteria become resistant to beta-lactam antibiotics?
- Increased production of antibiotic-binding proteins
- Changes in the bacterial cell wall
- Production of beta-lactamases (correct)
- Mutation of the beta-lactam ring
What is the purpose of adding beta-lactamase inhibitors to penicillin?
What is the purpose of adding beta-lactamase inhibitors to penicillin?
- To increase the absorption of penicillin
- To enhance the bactericidal activity of penicillin
- To prevent degradation of penicillin by beta-lactamases (correct)
- To reduce the allergic reactions to penicillin
Which of the following beta-lactam antibiotics is most susceptible to inactivation by amidases and lactamases?
Which of the following beta-lactam antibiotics is most susceptible to inactivation by amidases and lactamases?
- Cephalosporins
- Penicillins (correct)
- Carbapenems
- Monobactams
What is the characteristic of the lactam ring in carbapenems that makes them resistant to most common beta-lactamases?
What is the characteristic of the lactam ring in carbapenems that makes them resistant to most common beta-lactamases?
What is the consequence of the emergence of ESBL and carbapenemases?
What is the consequence of the emergence of ESBL and carbapenemases?
How are beta-lactamases typically encoded in bacteria?
How are beta-lactamases typically encoded in bacteria?
What is a characteristic of Avibactam, a beta-lactamase inhibitor?
What is a characteristic of Avibactam, a beta-lactamase inhibitor?
What is the indication for Amoxicillin/Clavulanate?
What is the indication for Amoxicillin/Clavulanate?
What is the mechanism of Clavulanate?
What is the mechanism of Clavulanate?
What is the indication for Ampicillin/Sulbactam?
What is the indication for Ampicillin/Sulbactam?
What is the characteristic of Penicillin G?
What is the characteristic of Penicillin G?
What is the characteristic of Amoxicillin?
What is the characteristic of Amoxicillin?
What is the primary mechanism of vancomycin's adverse effect of red man syndrome?
What is the primary mechanism of vancomycin's adverse effect of red man syndrome?
What is the bactericidal activity of vancomycin dependent on?
What is the bactericidal activity of vancomycin dependent on?
Which of the following is NOT an adverse effect of telavancin?
Which of the following is NOT an adverse effect of telavancin?
What is the primary mechanism of telavancin's antibacterial activity?
What is the primary mechanism of telavancin's antibacterial activity?
Why is vancomycin monitoring necessary?
Why is vancomycin monitoring necessary?
What is the comparative efficacy of telavancin to vancomycin?
What is the comparative efficacy of telavancin to vancomycin?
What is the primary use of Fosfomycin in treatment?
What is the primary use of Fosfomycin in treatment?
What is the mechanism of action of Cycloserine?
What is the mechanism of action of Cycloserine?
What is the primary adverse effect of Bacitracin?
What is the primary adverse effect of Bacitracin?
What is the function of bactoprenyl diphosphate in murein monomer synthesis?
What is the function of bactoprenyl diphosphate in murein monomer synthesis?
Why is Bacitracin not absorbed orally?
Why is Bacitracin not absorbed orally?
Which of the following antibiotics is safe to use in severe beta-lactam allergy?
Which of the following antibiotics is safe to use in severe beta-lactam allergy?
What is the mechanism of action of glycopeptides?
What is the mechanism of action of glycopeptides?
Which of the following antibiotics is effective against Pseudomonas?
Which of the following antibiotics is effective against Pseudomonas?
Why is cilastatin added to imipenem?
Why is cilastatin added to imipenem?
Which of the following antibiotics is not effective against atypical pneumonia and Legionella?
Which of the following antibiotics is not effective against atypical pneumonia and Legionella?
What is the spectrum of activity of 3rd generation cephalosporins?
What is the spectrum of activity of 3rd generation cephalosporins?
Which of the following antibiotics is used orally for C.difficile infections?
Which of the following antibiotics is used orally for C.difficile infections?
What is the indication for ceftaroline?
What is the indication for ceftaroline?
Which of the following is a characteristic of carbapenems?
Which of the following is a characteristic of carbapenems?
What is the concern with using ceftriaxone in neonates?
What is the concern with using ceftriaxone in neonates?