Become an Expert on Brugian Filariasis

What is the primary mode of transmission for W. bancrofti, B. malayi, and B. timori?

What is the maximum number of microfilariae that adult female worms can release per day?

When are microfilariae most abundant in the circulation?

How long does it take for L3 larvae to develop in the mosquito's thoracic muscle?

Where do L4-stage larvae migrate to after entering the feeding site?

What is the primary cause of overt clinical disease in infected persons?

Which type of filariasis causes a distinct, dramatic, and destructive adenolymphangitis?

W. bancrofti, B. malayi, and B. timori are parasites that have five distinct life cycle stages.
Adult female worms release up to 10,000 first-stage larvae or microfilariae per day, which circulate in blood.
Microfilariae are most abundant in the circulation at night (nocturnal periodicity) and sequester in the deep vascular beds during the day.
Microfilariae are ingested by mosquitoes and exsheath after the blood meal, penetrate the mosquito gut wall, and migrate to the mosquito's thoracic muscle where they grow and undergo two molts to infective third-stage larvae (L3) in 10 to 14 days.
The L3 actively enter the feeding site, migrate to the local lymphatics where they quickly molt to L4-stage larvae, and then migrate centrally in the lymphatic systems to develop into sexually mature, adult worms at 6 to 9 months.
Adult worms are long, threadlike organisms and have the ability to cause massive dilation of the surrounding and proximal lymphatics.
The type and extent of overt clinical disease are related to where adult worms accumulate.
Infected persons can exhibit acute manifestations, particularly acute filarial lymphangitis (AFL) and acute dermatolymphangioadenitis (ADLA).
The adenolymphangitis of brugian filariasis is distinct, dramatic, and destructive.
Brugian filariasis does not cause urogenital disease and chyluria.

Test your knowledge on the life cycle and clinical manifestations of W. bancrofti, B. malayi, and B. timori parasites. Learn about the intricate stages of their development, the nocturnal periodicity of microfilariae, and their transmission through mosquitoes. Challenge yourself on the types of clinical disease caused by these parasites and understand how the accumulation of adult worms affects different parts of the body. Take this quiz to become an expert on Brugian filariasis and related