11 Questions
What is the function of immunoglobulins as antibodies?
Combining with antigenic determinants to eliminate them
What is the role of immunoglobulins as plasma membrane-bound receptors on B-cells?
Signal reception for B-cell activation
What is the definition of an antigen?
A substance that induces a specific immune response
What does the term 'antigenic determinant' refer to?
A portion of an antigen that combines with specific immune response products
How are immunoglobulins named based on their migration in an electric field?
They are named because they migrate with globular proteins in an electrical field
What is the result of cleavage of Ig with papain?
Two Fab fragments and one Fc fragment
What is the term for the process by which antibodies cross epithelial layers?
Transcytosis
What is the term for the killing of cells mediated by antibodies and immune cells?
Antibody-dependent cell-mediated cytotoxicity (ADCC)
What is the source of pure immunoglobulin that made sequencing possible?
Multiple myeloma patients
What are the two types of light chains in immunoglobulins?
Kappa (κ) and lambda (λ)
What is the term for the process by which antibodies help to eliminate pathogens by marking them for destruction?
Opsonization
Learn about the structure of immunoglobulins (Ig), glycoprotein molecules produced by plasma cells in response to an immunogen, which function as antibodies. Explore key concepts such as immunogens, antigens, and antigenic determinants.
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