Basic Osteology Lecture Notes

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Questions and Answers

What is the primary function of osteoblasts in bone tissue?

  • To form new bone tissue (correct)
  • To provide structural support to ligaments
  • To maintain the bone matrix
  • To break down bone tissue

What distinguishes cancellous bone from compact bone?

  • Cancellous bone contains a dense arrangement of osteons.
  • Cancellous bone has a porous structure that facilitates lightweight support. (correct)
  • Cancellous bone is less vascularized than compact bone.
  • Cancellous bone does not contain bone cells.

Which cell type is primarily responsible for the resorption of bone tissue?

  • Osteoprogenitor cells
  • Osteoblasts
  • Osteoclasts (correct)
  • Osteocytes

What is a characteristic feature of the Harversian system in compact bone?

<p>It includes concentric circles of osteocytes around a central canal. (A)</p> Signup and view all the answers

Which process describes the development of bone from a fibrous membrane?

<p>Intramembranous ossification (D)</p> Signup and view all the answers

What is the primary function of cancellous bone?

<p>To provide structural support and store red bone marrow (A)</p> Signup and view all the answers

Which of the following statements about compact bone is true?

<p>It is composed of structural units called osteons (A)</p> Signup and view all the answers

What connects the lacunae in compact bone?

<p>Canaliculi (A)</p> Signup and view all the answers

What is the role of Volkmann's canals in compact bone?

<p>To connect blood vessels from the periosteum to the Haversian system (D)</p> Signup and view all the answers

How are nutrients supplied to cancellous bone?

<p>Directly from red bone marrow (C)</p> Signup and view all the answers

Which structure of compact bone acts as a conduit for blood supply?

<p>Central canal (A)</p> Signup and view all the answers

What is the composition of concentric lamellae in compact bone?

<p>Hard calcified intercellular substance (B)</p> Signup and view all the answers

Where do bones begin their development?

<p>As cartilage (D)</p> Signup and view all the answers

What is the term used for the structure that forms around the fracture site during bone repair?

<p>Bony collar (C)</p> Signup and view all the answers

Which stage follows fracture hematoma formation in the bone repair process?

<p>Fibrocartilaginous callus formation (C)</p> Signup and view all the answers

How often does the distal end of the femur undergo repair?

<p>Every 5-6 months (A)</p> Signup and view all the answers

What will likely happen to a limb that is in a cast in terms of bone mass?

<p>It will lose mass (C)</p> Signup and view all the answers

Which of the following best describes the complete process of bone remodeling?

<p>It is a constant process involving the renewal of old tissue (D)</p> Signup and view all the answers

What factors might affect bone growth and repair?

<p>Age and nutrition (A), Genetic predispositions and exercise (C)</p> Signup and view all the answers

What is a factor that could prolong healing time in bone repair?

<p>Poor nutrition (D)</p> Signup and view all the answers

Which part of the bone is primarily formed by secondary ossification centers?

<p>Epiphysis (A)</p> Signup and view all the answers

What is the primary function of the periosteum?

<p>To help with fracture repair and protect bone (B)</p> Signup and view all the answers

Which part of the long bone is primarily hollow and forms the central structure?

<p>Diaphysis (B)</p> Signup and view all the answers

What is the role of the endosteum?

<p>To line the canals passing through the cortical bone (D)</p> Signup and view all the answers

Where are the secondary ossification centers typically found?

<p>At various times during a child's development (C)</p> Signup and view all the answers

What is the main characteristic of the metaphysis during bone growth?

<p>It has a layer of hyaline cartilage known as the epiphyseal plate (B)</p> Signup and view all the answers

What is primarily found inside the epiphysis of long bones?

<p>Spongy bone containing red bone marrow (C)</p> Signup and view all the answers

What substance mainly composes the epiphyseal plate?

<p>Hyaline cartilage (A)</p> Signup and view all the answers

What is a key function of osteoblasts found in the endosteum?

<p>To synthesize new bone tissue (B)</p> Signup and view all the answers

What occurs during the fracture hematoma formation stage?

<p>Clotted blood is formed at the fracture site. (A)</p> Signup and view all the answers

What type of tissue is primarily formed during the fibrocartilaginous callus formation?

<p>Collagen fibers and cartilage. (C)</p> Signup and view all the answers

Which cells specifically invade the callus during the formation of the bony callus?

<p>Connective tissue stem cells and osteogenic cells. (C)</p> Signup and view all the answers

What is the primary role of phagocytic cells in the fracture healing process?

<p>To remove dead cells from the area of injury. (B)</p> Signup and view all the answers

How long does it typically take for the hematoma to form at a fracture site?

<p>6-8 hours. (A)</p> Signup and view all the answers

What characterizes the fibrocartilaginous callus?

<p>It consists of many collagen fibers and cartilage. (C)</p> Signup and view all the answers

Which stage follows the fibrocartilaginous callus formation in bone repair?

<p>Formation of bony callus. (C)</p> Signup and view all the answers

What happens to the fibrocartilaginous callus over time?

<p>It is converted into spongy bone. (C)</p> Signup and view all the answers

What is the primary function of osteoclasts during the bone remodeling process?

<p>To remove damaged or dead cells (B)</p> Signup and view all the answers

Which type of bone replaces spongy bone or the medullary cavity during bone remodeling?

<p>Compact bone (D)</p> Signup and view all the answers

What does synovial fluid primarily provide to the cartilage in a synovial joint?

<p>Nourishment and lubrication (A)</p> Signup and view all the answers

What role do bursae serve in relation to joints?

<p>They serve as cushions for joints (A)</p> Signup and view all the answers

Which structure covers the ends of bones in a synovial joint?

<p>Hyaline cartilage (C)</p> Signup and view all the answers

What is included in synovial fluid?

<p>Fats, sugars, serum, and hyaluronic acid (C)</p> Signup and view all the answers

How are ligaments important in joints?

<p>They connect bone to bone (B)</p> Signup and view all the answers

What leads to the remodeling of bone architecture to correct alignment?

<p>Natural healing processes over time (C)</p> Signup and view all the answers

Flashcards

Compact Bone Histology

Compact bone is dense and strong. It's structure is organized in units called osteons (Haversian systems).

Cancellous Bone

Cancellous bone is spongy and lightweight. It has a lattice-like structure.

Bone Composition & Function

Bone is mostly made up of collagen and calcium phosphate. Its functions include support, protection, movement, and blood cell production.

Osteoprogenitor Cells

Stem cells which give rise to osteoblasts.

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Osteoblasts

Bone-forming cells.

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Osteocytes

Mature bone cells.

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Osteoclasts

Bone-resorbing cells.

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Bone Growth

The process of increasing bone size and mass throughout life.

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Intramembranous Ossification

Formation of bone directly from mesenchymal tissues.

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Endochondral Ossification

Formation of bone by replacing cartilage models.

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Axial Skeleton

The part of the skeleton that forms the central axis, including the skull, vertebral column, and rib cage.

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Appendicular Skeleton

The part of the skeleton that includes the limbs and the supporting girdles.

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Bone's functions

Support, protection, movement, blood cell production, and mineral storage are the functions of the skeletal system.

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Lamellar bone

Compact bone that forms the outer layer of bones, protecting and supporting them.

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Cancellous bone

Spongy bone, found inside bones, providing support and storing red bone marrow.

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Haversian system/Osteon

Structural unit of compact bone, arranged in a regular pattern.

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Cancellous bone structure

An unorganized network of bone tissue surrounding bone marrow spaces.

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Compact bone structure

Many osteons (Haversian systems) are arranged in a regular pattern.

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Concentric lamellae

Rings of hard, calcified intercellular substance in osteons.

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Lacunae

Spaces in bone tissue containing osteocytes (bone cells).

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Canalliculi

Tiny canals that connect lacunae, allowing osteocytes to communicate and exchange materials.

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Volkmann's canals

Channels that run perpendicular to Haversian canals, connecting blood vessels.

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Trabeculae

Thin plates of bone forming the latticework of cancellous (spongy) bone.

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Primary Ossification Centre

The central part of a bone that begins to form bone tissue during or shortly after development in the womb. Examples include the shaft of long bones.

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Secondary Ossification Centre

An area in a bone that forms bone later in development than the primary centre.

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Periosteum

The fibrous membrane that covers the outside of a bone, helping with fracture repair, bone nourishment, and tendon/ligament attachment.

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Endosteum

The thin layer of cells lining the internal surface of a bone, covering trabeculae and canals.

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Diaphysis

The long, main shaft of a long bone.

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Medullary Cavity

The hollow area inside the diaphysis of a long bone, often containing marrow.

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Metaphysis

The region between the diaphysis and epiphysis of a long bone. Key for bone growth.

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Epiphysis

The rounded end of a long bone. Filled with spongy bone and red marrow.

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Epiphyseal plate

A layer of hyaline cartilage in the metaphysis that allows bone to grow in length during development.

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Primary ossification center

The initial point of bone development within a cartilage model.

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Fracture Hematoma Formation

The initial stage of bone repair, characterized by blood clot formation at the fracture site due to damaged blood vessels. This clot seals damaged vessels and prevents further bleeding.

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Secondary ossification centers

Additional centers that appear later in bone growth, usually at the ends, forming the epiphyses.

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Diaphysis

The shaft-like portion of a long bone, formed through thickening & lengthening of the formation collar.

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Fibrocartilaginous Callus Formation

The second stage of bone repair, where connective tissue cells (fibroblasts) enter, and lay down collagen fibres and cartilage. New blood vessels and cells form granulation tissue, and osteoblasts make initial spongy bone.

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Epiphysis

The expanded end of a long bone, often containing secondary ossification centers

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Bony Callus Formation

The final stage, where the fibrocartilaginous callus is replaced by spongy bone. Blood vessels and cells invade and, osteoblasts replace the soft callus with hard bone.

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Articular cartilage

Cartilage covering the ends of bones where they meet at joints.

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Hematoma

A localized collection of clotted blood, which forms at the fracture site as a result of broken blood vessels.

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Epiphyseal plate

A cartilaginous growth plate in developing long bones that allows for lengthwise growth.

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Granulation tissue

Newly formed connective tissue during the repair process that contains new blood vessels and inflammatory cells.

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Bone Repair Stages

The four phases of bone healing: Hematoma formation, fibrocartilaginous callus formation, bony callus formation, and bone remodeling

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Epiphyseal closure

The point when the epiphyseal plate fuses, stopping bone growth in length.

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Bone remodeling

The continuous process of bone resorption and formation.

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Bone repair stages

Fracture Hematoma Formation, Fibrocartilaginous callus formation, Bony Callus Formation... and more.

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Factors affecting bone growth

Various factors may influence bone growth, including nutrition, genetics, and hormones.

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Bone Remodelling

The process where osteoclasts break down damaged/dead bone tissue, and new spongy/compact bone forms to repair fractures. This leads to strong, aligned bone.

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Synovial Joint

A type of joint with a joint cavity, cartilage-covered bone ends, a capsule lined with a synovial membrane and synovial fluid, bursae (cushions), and ligaments/tendons supporting the joint.

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Joint Capsule

Connective tissue encasing a synovial joint, holding the bones and contents of the joint.

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Hyaline Cartilage

Smooth cartilage covering the ends of bones in synovial joints; providing cushioning and reducing friction.

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Synovial Membrane

Membrane lining the joint capsule of a synovial joint, secreting synovial fluid.

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Synovial Fluid

Fluid in the joint cavity of synovial joints that nourishes cartilage, reduces friction, and lubricates the joint.

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Bursae

Small pouches of synovial fluid located around a synovial joint; providing cushioning and reducing friction.

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Ligaments

Fibrous bands connecting bone to bone in a joint, providing stability.

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Tendons

Connective tissues connecting muscles to bones, enabling movement.

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Study Notes

Basic Osteology Lecture Notes

  • The lecture covers compact and cancellous bone histology, bone composition, bone cell types (osteoprogenitor cells, osteoblasts, osteocytes, osteoclasts), bone growth processes (intramembranous and endochondral ossification), factors affecting bone growth, and types of skeletons (endoskeleton, exoskeleton).
  • The human skeleton is comprised of approximately 206 bones, divided into the axial skeleton (skull/face, vertebral column, and thorax) and the appendicular skeleton (shoulder girdle, upper extremities, pelvic girdle, and lower extremities).
  • Bones (skull/cranium) are categorized into 8 cranial bones, 14 facial bones, 1 hyoid, and 6 ossicles.
  • The vertebral column includes 7 cervical, 12 thoracic, 5 lumbar vertebrae, 1 sacrum, and 1 coccyx bone.
  • The thorax contains 25 bones (1 sternum, 24 ribs).
  • The shoulder girdle consists of 4 bones (2 clavicles, 2 scapulae).
  • The upper extremities consist of 60 bones (2 humerus, 2 radius, 2 ulna, 16 carpals, 10 metacarpals, 28 phalanges).
  • The pelvic girdle consists of 2 innominate bones (each comprising the ilium, ischium, and pubis).
  • The lower extremities include 60 bones (2 femurs, 2 fibulas, 2 tibias, 2 patellas, 14 tarsals, 10 metatarsals, and 28 phalanges).
  • Bone types include long bones, short bones, flat bones, irregular bones, and sesamoid bones.
  • Bone microstructure involves: Woven bone – fragile in development and repair; Lamellar bone- compact/cortical covering spongy bone, a stronger structure; Cancellous or spongy- trabecular bone found in the ends of long bones, provides support.
  • Compact bone contains Haversian systems/osteons (structural units) arranged regularly; the structures consist of a Haversian canal, lamellae (calcified rings), lacunae (spaces for osteocytes), canaliculi (tiny canals radiating out connecting lacunae), and Volkmann’s canals (channels running at 90° to the central canal connecting blood vessels to the periosteum).
  • Cancellous bone is unorganized extensions of bone tissue surrounding bone marrow spaces.
  • Bone growth and development includes primary and secondary ossification (the process by which bones form from embryonic tissue). Primary ossification begins in the womb, usually around the shaft of the long bone. Secondary ossification happens later in different times of the child’s development. Bone development stages include cartilage template (surrounded by perichondrium), bony collar formation, primary centre formation, blood vessels entering, marrow cavity formation, collar thickening and lengthening forming the diaphysis, and secondary ossification centres forming the epiphysis.
  • The epiphyseal growth plate (hyaline cartilage) separates the epiphysis from the rest of the bone & bone lengthens.
  • The metaphysis is the region proximal to the growth plate where ossification occurs
  • The periosteum (fibrous membrane covering the bone) and the endosteum (inner membrane facing the medullary cavity) are key parts of bone structure. The periosteum protects and nourishes the bone; endosteum has blood supply & contains osteoblasts & osteoclasts.
  • Bony repair involves fracture hematoma formation, fibrocartilaginous callus formation, formation of bony callus, and bone remodelling.
  • Synovial joints have a joint cavity containing synovial fluid for nourishing and lubricating cartilage. Pouches of fluid (bursae) cushion the joint. The capsule and membranes and the joint cavity are lined by synovial membrane, cartilage, and fluid.

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