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Questions and Answers
Which of the following is a disease caused by a failure to express class II major histocompatibility complex (MHC) molecules?
Which of the following is a disease caused by a failure to express class II major histocompatibility complex (MHC) molecules?
- Hemophagocytic lymphohistiocytosis (HLH)
- Th1 responses
- Bare lymphocyte syndrome (correct)
- Selective T cell deficiency
Which of the following is true about the bare lymphocyte syndrome?
Which of the following is true about the bare lymphocyte syndrome?
- It is associated with nontuberculous mycobacterial infections.
- It affects the differentiation of naive T cells into effector cells.
- It leads to a decrease in CD4+ T cells due to defective maturation in the thymus. (correct)
- It is caused by mutations affecting various signaling pathways or cytokines.
Which of the following is a characteristic of hemophagocytic lymphohistiocytosis (HLH) syndromes?
Which of the following is a characteristic of hemophagocytic lymphohistiocytosis (HLH) syndromes?
- It is associated with fungal and bacterial infections.
- It is a disease caused by a failure to express class II major histocompatibility complex (MHC) molecules.
- It is caused by mutations affecting various signaling pathways or cytokines.
- It is characterized by systemic activation of immune cells, usually in response to infections. (correct)
Which type of mutations can result in persistent infections and excessive production of IFNγ?
Which type of mutations can result in persistent infections and excessive production of IFNγ?
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What is the main consequence of excessive macrophage activation in patients with these mutations?
What is the main consequence of excessive macrophage activation in patients with these mutations?
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What is the syndrome called in patients with mutations resulting in persistent infections and excessive macrophage activation?
What is the syndrome called in patients with mutations resulting in persistent infections and excessive macrophage activation?
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