Bacterial Meningitis Pathogenesis

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Questions and Answers

What bacterial component inhibits neutrophil phagocytosis and resists classical complement‐mediated bactericidal activity?

  • Neisserial surface protein A
  • Outer membrane proteins factor H‐binding protein
  • Polysaccharide capsule (correct)
  • Pneumococcal surface proteins

Which bacterial component may enhance bloodstream survival by facilitating intravascular replication?

  • Neisserial surface protein A
  • Polysaccharide capsule (correct)
  • Toxin pneumolysin
  • Outer membrane proteins factor H‐binding protein

Which pathogen mentioned in the text is specifically known for the activation of the alternate complement pathway through its capsular polysaccharide?

  • E. coli
  • H. influenzae
  • N. meningitidis
  • S. pneumoniae (correct)

Which component forms the Blood–Brain Barrier, regulating the passage of molecules and protecting the brain from microorganisms and toxins?

<p>Polysaccharide capsule (B)</p> Signup and view all the answers

Which encapsulated pathogen is mentioned as one of the most common meningeal pathogens in the text?

<p>N. meningitidis (A)</p> Signup and view all the answers

Which outer membrane protein is known for binding to factor H, evading host immune responses?

<p>Pneumococcal surface proteins (A)</p> Signup and view all the answers

Which bacterial component is highlighted for preferentially binding to the organism and blocking the beneficial effects of certain antibodies?

<p>Polysaccharide capsule (D)</p> Signup and view all the answers

What type of antibodies do bacteria like N. meningitidis block, according to the text?

<p>IgG and IgM antibodies (C)</p> Signup and view all the answers

Which host defense mechanisms counteract the antiphagocytic effects of the bacterial capsule?

<p>Activation of the alternate complement pathway (C)</p> Signup and view all the answers

What do brain microvascular endothelial cells, astrocytes, and pericytes collectively form in the text?

<p>Blood–Brain Barrier (C)</p> Signup and view all the answers

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