10 Questions
What bacterial component inhibits neutrophil phagocytosis and resists classical complement‐mediated bactericidal activity?
Polysaccharide capsule
Which bacterial component may enhance bloodstream survival by facilitating intravascular replication?
Polysaccharide capsule
Which pathogen mentioned in the text is specifically known for the activation of the alternate complement pathway through its capsular polysaccharide?
S. pneumoniae
Which component forms the Blood–Brain Barrier, regulating the passage of molecules and protecting the brain from microorganisms and toxins?
Polysaccharide capsule
Which encapsulated pathogen is mentioned as one of the most common meningeal pathogens in the text?
N. meningitidis
Which outer membrane protein is known for binding to factor H, evading host immune responses?
Pneumococcal surface proteins
Which bacterial component is highlighted for preferentially binding to the organism and blocking the beneficial effects of certain antibodies?
Polysaccharide capsule
What type of antibodies do bacteria like N. meningitidis block, according to the text?
IgG and IgM antibodies
Which host defense mechanisms counteract the antiphagocytic effects of the bacterial capsule?
Activation of the alternate complement pathway
What do brain microvascular endothelial cells, astrocytes, and pericytes collectively form in the text?
Blood–Brain Barrier
Test your knowledge on the pathogenesis and pathophysiology of bacterial meningitis based on a study by Tunkel AR and Scheld WM. Focus on microbial survival, evasion strategies, and factors involved in inhibiting complement activation and bacterial killing.
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