Podcast
Questions and Answers
What are virulence factors in the context of periodontal disease?
What are virulence factors in the context of periodontal disease?
- Mechanisms that allow bacteria to colonize and damage tissues (correct)
- Proteins released by host cells in response to infections
- Methods that enhance the immune response against bacteria
- Genetic markers related to periodontal disease susceptibility
Which of the following statements best describes lipopolysaccharides (LPS)?
Which of the following statements best describes lipopolysaccharides (LPS)?
- They are endotoxins found in the outer layer of Gram-positive bacteria.
- They are enzymes produced by bacteria that degrade host proteins.
- They play a crucial role in the ability of bacteria to invade host tissues. (correct)
- They are proteins that help bacteria evade the immune system.
Which environmental factor is known to impact the immune response in periodontal disease?
Which environmental factor is known to impact the immune response in periodontal disease?
- Consumption of a high-sugar diet
- Tobacco smoking (correct)
- Exposure to high levels of stress
- Genetic predisposition to infections
What role do B-lymphocytes play in the immune response during periodontal disease?
What role do B-lymphocytes play in the immune response during periodontal disease?
Which statement accurately describes acute inflammation in the context of periodontal disease?
Which statement accurately describes acute inflammation in the context of periodontal disease?
Which bacterium is known for its gingipains that enable nutrient acquisition from gingival crevicular fluid (GCF)?
Which bacterium is known for its gingipains that enable nutrient acquisition from gingival crevicular fluid (GCF)?
What is one of the mechanisms by which Aggregatibacter actinomycetemcomitans disrupts host defense?
What is one of the mechanisms by which Aggregatibacter actinomycetemcomitans disrupts host defense?
Which of the following factors is associated with Treponema denticola's ability to disrupt host defenses?
Which of the following factors is associated with Treponema denticola's ability to disrupt host defenses?
Tannerella forsythia is primarily recognized for producing which type of factors?
Tannerella forsythia is primarily recognized for producing which type of factors?
What role does the carbohydrate capsule of Porphyromonas gingivalis play in its pathogenicity?
What role does the carbohydrate capsule of Porphyromonas gingivalis play in its pathogenicity?
What is the primary role of Cytokine IL-1 in periodontitis?
What is the primary role of Cytokine IL-1 in periodontitis?
Which cytokine is known for inhibiting bone formation?
Which cytokine is known for inhibiting bone formation?
What is the effect of Prostaglandin Eâ‚‚ (PGEâ‚‚) in periodontal disease?
What is the effect of Prostaglandin Eâ‚‚ (PGEâ‚‚) in periodontal disease?
Which of the following is a major source of MMP enzymes in periodontal tissue?
Which of the following is a major source of MMP enzymes in periodontal tissue?
What happens when there is a disruption in the MMP-TIMP balance?
What happens when there is a disruption in the MMP-TIMP balance?
Which cytokine is primarily associated with connective tissue destruction?
Which cytokine is primarily associated with connective tissue destruction?
What is the primary action of MMP enzymes in periodontal tissues?
What is the primary action of MMP enzymes in periodontal tissues?
Which mediator is critical for triggering osteoclasts to destroy bone?
Which mediator is critical for triggering osteoclasts to destroy bone?
Flashcards
Porphyromonas gingivalis and Gingipains
Porphyromonas gingivalis and Gingipains
Porphyromonas gingivalis uses gingipains to digest gingival crevicular fluid (GCF) for nutrients.
Aggregatibacter actinomycetemcomitans (Aa) Leukotoxin
Aggregatibacter actinomycetemcomitans (Aa) Leukotoxin
Aa leukotoxin kills white blood cells (WBCs), weakening the body's defense against infection.
Tannerella forsythia and Proteases
Tannerella forsythia and Proteases
Tannerella forsythia produces proteases; substances help break down proteins in tissues.
Treponema denticola and Tissue Invasion
Treponema denticola and Tissue Invasion
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Bacteria and Host Defenses
Bacteria and Host Defenses
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Host response in periodontal disease
Host response in periodontal disease
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Bacterial virulence factors
Bacterial virulence factors
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Lipopolysaccharide (LPS)
Lipopolysaccharide (LPS)
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Acute inflammation in periodontitis
Acute inflammation in periodontitis
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Inflammatory biochemical mediators
Inflammatory biochemical mediators
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Cytokines
Cytokines
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Key Cytokines in Periodontitis
Key Cytokines in Periodontitis
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Prostaglandins
Prostaglandins
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PGEâ‚‚
PGEâ‚‚
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MMPs (Matrix Metalloproteinases)
MMPs (Matrix Metalloproteinases)
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MMP-TIMP Balance
MMP-TIMP Balance
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What is the source of MMPs?
What is the source of MMPs?
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What is the role of PGEâ‚‚ in periodontitis?
What is the role of PGEâ‚‚ in periodontitis?
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Study Notes
Bacteria Associated with Periodontal Disease
-
Porphyromonas gingivalis (P. gingivalis):
- Capsule - can help resist some host defenses
- Produces gingipains to enable the bacterium to use CPF as a source of nutrients
- LPS (Lipopolysaccharide)
- Haemagglutinins + platelet aggregators
- Fimbrae and tissue invasion
- Can suppress the early PMN (polymorphonuclear leukocytes) response
-
Aggregatibacter Actinomycetemcomitans (A.A):
- Leukotoxin - can kill WBCs. Therefore, it interrupts host defenses
- Produces proteases including collagenase
- Can invade epithelial host cells
-
Tannerella forsythia
- Proteases and apoptotic factors
-
Treponema denticola:
- Adherence factors can bind to microorganisms
- Mobile and can invade host tissues
- Disrupts host defense
- Delays wound healing by inhibiting migration of PMNs and degrading cytokines.
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Description
Explore the key bacterial players associated with periodontal disease, including their mechanisms of action and effects on host defenses. This quiz will cover species such as Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, highlighting their unique attributes. Test your knowledge on how these bacteria contribute to oral health issues.
