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B Cell Differentiation Quiz

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Questions and Answers

What is required for B cell activation by antigen?

Expression of MHC on B cell surface

Isotype switching

Cross-linking of BCRs (correct)

Endocytosis of BCR + Ag

What is required for B cell activation by antigen?

Cross-linking of the B cell receptors (correct)

Interaction with T cells

Expression of MHC class II on the B cell surface

Binding of complement receptors on the B cell surface

What is a cSMAC in B cell activation?

A type of cytokine receptor

A type of chemokine receptor

A central SupraMolecular Activation Cluster (correct)

A peripheral cell adhesion molecule

What are the two ways for B cells to get cross-linked antigen?

Large repeating Ags and smaller Ags picked up by macrophages, dendritic cells, and FDCs Signup and view all the answers

What is the role of chemokines in B cell activation?

To tell the B cell to migrate to the cortex-paracortex region Signup and view all the answers

What is a cSMAC and what does it contain?

A central SupraMolecular Activation Cluster containing Ag-bound BCRs and Ig-alpha/Ig-beta Signup and view all the answers

What does the pSMAC contain and what is its function?

A peripheral SupraMolecular Activation Cluster containing cell adhesion molecules that hold the cells together Signup and view all the answers

What is the role of CD40 in B cell proliferation?

Assists in B cell proliferation Signup and view all the answers

What is the function of CD40 and CD80/86 on the B cell surface?

To make the cell sensitive to TH cell cytokines for proliferation Signup and view all the answers

What is the result of B cell activation in the follicle/germinal center?

Intense proliferation of B cells, isotype switching, somatic hypermutation for affinity maturation Signup and view all the answers

What is the cognate interaction between the B cell and TH cell?

B cell presents Ag peptide from Ag bound to BCR to the TH cell TCR Signup and view all the answers

What is the primary antibody response to antigen?

Lag period of ~4-7 days, clonal selection, clonal expansion, differentiation to plasma cells, first Abs are IgM Signup and view all the answers

What is the secondary antibody response to antigen?

Shorter lag period before seeing Abs, stronger and higher response, mostly from memory B & T cells, mostly IgG Signup and view all the answers

What is the result of the B cell in the follicle/germinal center?

Intense proliferation of the B cells, isotype switching, and somatic hypermutation for affinity maturation Signup and view all the answers

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Description

"Test your knowledge on B cell differentiation with this quiz! Learn about the activation of B cells by antigen, the seven steps involved, and the crucial role of cross-linking B cell receptors. Discover the two ways B cells can get cross-linked antigen, and explore the differences between large and small antigens. Sharpen your understanding of B cell biology with this informative quiz."