B Cell Differentiation Quiz

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Questions and Answers

What is required for B cell activation by antigen?

  • Expression of MHC on B cell surface
  • Isotype switching
  • Cross-linking of BCRs (correct)
  • Endocytosis of BCR + Ag

What is required for B cell activation by antigen?

  • Cross-linking of the B cell receptors (correct)
  • Interaction with T cells
  • Expression of MHC class II on the B cell surface
  • Binding of complement receptors on the B cell surface

What is a cSMAC in B cell activation?

  • A type of cytokine receptor
  • A type of chemokine receptor
  • A central SupraMolecular Activation Cluster (correct)
  • A peripheral cell adhesion molecule

What are the two ways for B cells to get cross-linked antigen?

<p>Large repeating Ags and smaller Ags picked up by macrophages, dendritic cells, and FDCs (C)</p> Signup and view all the answers

What is the role of chemokines in B cell activation?

<p>To tell the B cell to migrate to the cortex-paracortex region (D)</p> Signup and view all the answers

What is a cSMAC and what does it contain?

<p>A central SupraMolecular Activation Cluster containing Ag-bound BCRs and Ig-alpha/Ig-beta (A)</p> Signup and view all the answers

What does the pSMAC contain and what is its function?

<p>A peripheral SupraMolecular Activation Cluster containing cell adhesion molecules that hold the cells together (B)</p> Signup and view all the answers

What is the role of CD40 in B cell proliferation?

<p>Assists in B cell proliferation (B)</p> Signup and view all the answers

What is the function of CD40 and CD80/86 on the B cell surface?

<p>To make the cell sensitive to TH cell cytokines for proliferation (D)</p> Signup and view all the answers

What is the result of B cell activation in the follicle/germinal center?

<p>Intense proliferation of B cells, isotype switching, somatic hypermutation for affinity maturation (C)</p> Signup and view all the answers

What is the cognate interaction between the B cell and TH cell?

<p>B cell presents Ag peptide from Ag bound to BCR to the TH cell TCR (D)</p> Signup and view all the answers

What is the primary antibody response to antigen?

<p>Lag period of ~4-7 days, clonal selection, clonal expansion, differentiation to plasma cells, first Abs are IgM (A)</p> Signup and view all the answers

What is the secondary antibody response to antigen?

<p>Shorter lag period before seeing Abs, stronger and higher response, mostly from memory B &amp; T cells, mostly IgG (D)</p> Signup and view all the answers

What is the result of the B cell in the follicle/germinal center?

<p>Intense proliferation of the B cells, isotype switching, and somatic hypermutation for affinity maturation (D)</p> Signup and view all the answers

Flashcards

B Cell Activation Requirement

B cell activation requires cross-linking of B cell receptors (BCRs) by antigens.

cSMAC Definition

cSMAC stands for central SupraMolecular Activation Cluster, a key structure in B cell activation.

B Cell Antigen Acquisition

B cells can get cross-linked antigens through large repeating antigens or smaller antigens picked up by macrophages, dendritic cells, and FDCs.

Chemokine Role in B Cell Activation

Chemokines guide B cells to migrate to the cortex-paracortex region for activation.

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cSMAC Components

The cSMAC contains antigen-bound BCRs and Ig-alpha/Ig-beta molecules.

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pSMAC Function

The pSMAC contains cell adhesion molecules that hold the cells together during activation.

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CD40 Role

CD40 assists in B cell proliferation.

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CD40 and CD80/86 Function

CD40 and CD80/86 on the B cell surface make the cell sensitive to TH cell cytokines for proliferation.

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B Cell Activation Results

B cell activation in the germinal center results in intense proliferation, isotype switching, and somatic hypermutation.

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Cognate Interaction

The cognate interaction is when a B cell presents an antigen peptide to a TH cell TCR via its BCR.

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Primary Antibody Response

The primary antibody response has a lag period, clonal selection/expansion, differentiation to plasma cells, and initial IgM production.

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Secondary Antibody Response

The secondary antibody response has a shorter lag, stronger response, mostly from memory cells, and mostly IgG production.

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B Cell Follicle/Germinal Center Events

Intense proliferation, isotype switching, and somatic hypermutation happens in follicle/germinal center.

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B cell activated in follicle/germinal center

After activation, B cells undergo intense proliferation, isotype switching and somatic hypermutation.

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