14 Questions
What is required for B cell activation by antigen?
Cross-linking of BCRs
What is required for B cell activation by antigen?
Cross-linking of the B cell receptors
What is a cSMAC in B cell activation?
A central SupraMolecular Activation Cluster
What are the two ways for B cells to get cross-linked antigen?
Large repeating Ags and smaller Ags picked up by macrophages, dendritic cells, and FDCs
What is the role of chemokines in B cell activation?
To tell the B cell to migrate to the cortex-paracortex region
What is a cSMAC and what does it contain?
A central SupraMolecular Activation Cluster containing Ag-bound BCRs and Ig-alpha/Ig-beta
What does the pSMAC contain and what is its function?
A peripheral SupraMolecular Activation Cluster containing cell adhesion molecules that hold the cells together
What is the role of CD40 in B cell proliferation?
Assists in B cell proliferation
What is the function of CD40 and CD80/86 on the B cell surface?
To make the cell sensitive to TH cell cytokines for proliferation
What is the result of B cell activation in the follicle/germinal center?
Intense proliferation of B cells, isotype switching, somatic hypermutation for affinity maturation
What is the cognate interaction between the B cell and TH cell?
B cell presents Ag peptide from Ag bound to BCR to the TH cell TCR
What is the primary antibody response to antigen?
Lag period of ~4-7 days, clonal selection, clonal expansion, differentiation to plasma cells, first Abs are IgM
What is the secondary antibody response to antigen?
Shorter lag period before seeing Abs, stronger and higher response, mostly from memory B & T cells, mostly IgG
What is the result of the B cell in the follicle/germinal center?
Intense proliferation of the B cells, isotype switching, and somatic hypermutation for affinity maturation
Study Notes
"Test your knowledge on B cell differentiation with this quiz! Learn about the activation of B cells by antigen, the seven steps involved, and the crucial role of cross-linking B cell receptors. Discover the two ways B cells can get cross-linked antigen, and explore the differences between large and small antigens. Sharpen your understanding of B cell biology with this informative quiz."
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