B Cell Activation and Proliferation Quiz

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What is the role of CD21 in B cell activation?

Is the signaling chain of the complex

Recognizes C3d fragments deposited on pathogens (correct)

Forms signaling complex with CD19

Causes clustering of BCR

What happens to the surface IgM of an activated B cell?

It is no longer surface-bound, but secreted (correct)

It is still surface-bound but with reduced functionality

It becomes more responsive to antigens

It undergoes somatic hypermutation

Which enzyme is responsible for mediating somatic hypermutation and isotype switching in activated B cells?

CD19

Activation-induced cytidine deaminase (AID) (correct)

IL-4

CD27

What controls the synthesis of activation-induced cytidine deaminase (AID)?

IL-4 and CD-40 activation signals Signup and view all the answers

What is the main function of memory B cells?

Allow for more rapid and robust secondary antibody response Signup and view all the answers

What happens to activated B cells during differentiation to plasma cells?

They stop MHC class II expression Signup and view all the answers

What leads to changes in gene expression in B cells upon antigen binding?

Clustering of BCR Signup and view all the answers

What is responsible for the production of 'natural antibodies'?

B-1 cells Signup and view all the answers

Which type of antigens can stimulate naïve B cells in the absence of T cell help?

Lipopolysaccharide antigens Signup and view all the answers

What is limited in the absence of T cell help when responding to thymus-independent (TI) antigens?

Class switching Signup and view all the answers

Which type of B cells preferentially respond to T-independent antigens?

B-1 cells Signup and view all the answers

What do most mature B cells in the adult circulation express?

'Usual B cell markers' Signup and view all the answers

What is necessary for B cell activation by both T-dependent and T-independent antigens?

Signal #2 Signup and view all the answers

'Cytokine control of antibody isotype' refers to the regulation of ______.

'Antibody isotype' Signup and view all the answers

'Thymus-independent (TI) antigens' can stimulate naïve B cells without the need for ______.

'T cell help' Signup and view all the answers

B Cell Activation and Proliferation Quiz

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