Podcast
Questions and Answers
What is the role of CD21 in B cell activation?
What is the role of CD21 in B cell activation?
- Is the signaling chain of the complex
- Recognizes C3d fragments deposited on pathogens (correct)
- Forms signaling complex with CD19
- Causes clustering of BCR
What happens to the surface IgM of an activated B cell?
What happens to the surface IgM of an activated B cell?
- It is no longer surface-bound, but secreted (correct)
- It is still surface-bound but with reduced functionality
- It becomes more responsive to antigens
- It undergoes somatic hypermutation
Which enzyme is responsible for mediating somatic hypermutation and isotype switching in activated B cells?
Which enzyme is responsible for mediating somatic hypermutation and isotype switching in activated B cells?
- CD19
- Activation-induced cytidine deaminase (AID) (correct)
- IL-4
- CD27
What controls the synthesis of activation-induced cytidine deaminase (AID)?
What controls the synthesis of activation-induced cytidine deaminase (AID)?
What is the main function of memory B cells?
What is the main function of memory B cells?
What happens to activated B cells during differentiation to plasma cells?
What happens to activated B cells during differentiation to plasma cells?
What leads to changes in gene expression in B cells upon antigen binding?
What leads to changes in gene expression in B cells upon antigen binding?
What is responsible for the production of 'natural antibodies'?
What is responsible for the production of 'natural antibodies'?
Which type of antigens can stimulate naïve B cells in the absence of T cell help?
Which type of antigens can stimulate naïve B cells in the absence of T cell help?
What is limited in the absence of T cell help when responding to thymus-independent (TI) antigens?
What is limited in the absence of T cell help when responding to thymus-independent (TI) antigens?
Which type of B cells preferentially respond to T-independent antigens?
Which type of B cells preferentially respond to T-independent antigens?
What do most mature B cells in the adult circulation express?
What do most mature B cells in the adult circulation express?
What is necessary for B cell activation by both T-dependent and T-independent antigens?
What is necessary for B cell activation by both T-dependent and T-independent antigens?
'Cytokine control of antibody isotype' refers to the regulation of ______.
'Cytokine control of antibody isotype' refers to the regulation of ______.
'Thymus-independent (TI) antigens' can stimulate naïve B cells without the need for ______.
'Thymus-independent (TI) antigens' can stimulate naïve B cells without the need for ______.
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