B Cell Activation and Proliferation Quiz
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Questions and Answers

What is the role of CD21 in B cell activation?

  • Is the signaling chain of the complex
  • Recognizes C3d fragments deposited on pathogens (correct)
  • Forms signaling complex with CD19
  • Causes clustering of BCR

    • What happens to the surface IgM of an activated B cell?

  • It is no longer surface-bound, but secreted (correct)
  • It is still surface-bound but with reduced functionality
  • It becomes more responsive to antigens
  • It undergoes somatic hypermutation

    • Which enzyme is responsible for mediating somatic hypermutation and isotype switching in activated B cells?

  • CD19
  • Activation-induced cytidine deaminase (AID) (correct)
  • IL-4
  • CD27

    • What controls the synthesis of activation-induced cytidine deaminase (AID)?

    <p>IL-4 and CD-40 activation signals</p> Signup and view all the answers

    What is the main function of memory B cells?

    <p>Allow for more rapid and robust secondary antibody response</p> Signup and view all the answers

    What happens to activated B cells during differentiation to plasma cells?

    <p>They stop MHC class II expression</p> Signup and view all the answers

    What leads to changes in gene expression in B cells upon antigen binding?

    <p>Clustering of BCR</p> Signup and view all the answers

    What is responsible for the production of 'natural antibodies'?

    <p>B-1 cells</p> Signup and view all the answers

    Which type of antigens can stimulate naïve B cells in the absence of T cell help?

    <p>Lipopolysaccharide antigens</p> Signup and view all the answers

    What is limited in the absence of T cell help when responding to thymus-independent (TI) antigens?

    <p>Class switching</p> Signup and view all the answers

    Which type of B cells preferentially respond to T-independent antigens?

    <p>B-1 cells</p> Signup and view all the answers

    What do most mature B cells in the adult circulation express?

    <p>'Usual B cell markers'</p> Signup and view all the answers

    What is necessary for B cell activation by both T-dependent and T-independent antigens?

    <p>Signal #2</p> Signup and view all the answers

    'Cytokine control of antibody isotype' refers to the regulation of ______.

    <p>'Antibody isotype'</p> Signup and view all the answers

    'Thymus-independent (TI) antigens' can stimulate naïve B cells without the need for ______.

    <p>'T cell help'</p> Signup and view all the answers

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