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Questions and Answers
What is the probable reason for aztreonam not contributing to cross-resistances in free amino group β-lactam antibiotics, aminopenicillins, and first-generation aminopenicillins?
What is the probable reason for aztreonam not contributing to cross-resistances in free amino group β-lactam antibiotics, aminopenicillins, and first-generation aminopenicillins?
- It is not employed within veterinary medicine (correct)
- It is a β-lactamase inhibitor
- It has a bicyclic structure similar to penicillins, cephalosporins, and carbapenems
- Its high resistance to both exonuclease and β-lactamase
What is the characteristic of monobactams that distinguishes them from other β-lactam antibiotics?
What is the characteristic of monobactams that distinguishes them from other β-lactam antibiotics?
- They are effective against Gram-positive bacteria
- They are bicyclic
- They are semi-synthetic and monocyclic (correct)
- They are derived from Streptomyces species
What is the mechanism by which aztreonam mediates its activity against certain bacteria?
What is the mechanism by which aztreonam mediates its activity against certain bacteria?
- Through its narrow group of gonococcal plasmid genes (correct)
- Through its inhibition of β-lactamase
- Through its interaction with the bacterial cell wall
- Through its high resistance to both exonuclease and β-lactamase
What is the common structural feature of β-lactam antimicrobials?
What is the common structural feature of β-lactam antimicrobials?
What is the class of β-lactam antimicrobials that includes aztreonam?
What is the class of β-lactam antimicrobials that includes aztreonam?
What is the primary use of aztreonam?
What is the primary use of aztreonam?
What is the significance of aztreonam's high resistance to both exonuclease and β-lactamase?
What is the significance of aztreonam's high resistance to both exonuclease and β-lactamase?
What is the common target of β-lactam antimicrobials?
What is the common target of β-lactam antimicrobials?
Study Notes
Aztreonam and β-Lactam Antibiotics
- Aztreonam is not used in veterinary medicine, so it is unlikely to have contributed to cross-resistance in β-lactam antibiotics.
- Contaminations in registered feed products are due to technological or cross-contaminations during manufacturing, not from the use of aztreonam.
Monobactams
- Monobactams are a separate class of β-lactam antibiotics, semi-synthetic and monocyclic, unlike penicillins, cephalosporins, and carbapenems.
- Aztreonam is the only commercially available β-lactam compound, used as a last-resort antibiotic against gram-negative bacteria.
- Aztreonam's efficacy against penicillin-resistant and oxacillin-resistant methicillin-resistant strains is due to its high resistance to exonuclease and β-lactamase.
Activity against Gram-Positive Bacteria
- Aztreonam's activity against S.pneumoniae, Staphylococcus aureus, and Streptococcus pyogenes is mediated by a narrow group of gonococcal plasmid genes that encode aztreonam.
β-Lactam Antimicrobials
- The class of β-lactam antimicrobials includes penicillins, cephalosporins, carbapenems, monobactams, and β-lactamase inhibitors like clavulanic acid, sulbactam, and tazobactam.
- These drugs are used to treat infections caused by both Gram-positive and Gram-negative bacteria.
- They contain a four-atom β-lactam ring in their molecular structure, which is responsible for their antimicrobial activities.
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Description
Quiz about the use of aztreonam in veterinary medicine and its relation to beta-lactam antibiotics and cross-resistances. Covers the difference between aztreonam and other beta-lactam antibiotics like ampicillin and amoxicillin.
