8 Questions
What is the probable reason for aztreonam not contributing to cross-resistances in free amino group β-lactam antibiotics, aminopenicillins, and first-generation aminopenicillins?
It is not employed within veterinary medicine
What is the characteristic of monobactams that distinguishes them from other β-lactam antibiotics?
They are semi-synthetic and monocyclic
What is the mechanism by which aztreonam mediates its activity against certain bacteria?
Through its narrow group of gonococcal plasmid genes
What is the common structural feature of β-lactam antimicrobials?
A four-atom β-lactam ring
What is the class of β-lactam antimicrobials that includes aztreonam?
Monobactams
What is the primary use of aztreonam?
As a last-resort antifungal against Gram-negative bacteria
What is the significance of aztreonam's high resistance to both exonuclease and β-lactamase?
It makes it effective against penicillin-resistant and oxacillin-resistant methicillin-resistant strains
What is the common target of β-lactam antimicrobials?
The bacterial cell wall
Study Notes
Aztreonam and β-Lactam Antibiotics
- Aztreonam is not used in veterinary medicine, so it is unlikely to have contributed to cross-resistance in β-lactam antibiotics.
- Contaminations in registered feed products are due to technological or cross-contaminations during manufacturing, not from the use of aztreonam.
Monobactams
- Monobactams are a separate class of β-lactam antibiotics, semi-synthetic and monocyclic, unlike penicillins, cephalosporins, and carbapenems.
- Aztreonam is the only commercially available β-lactam compound, used as a last-resort antibiotic against gram-negative bacteria.
- Aztreonam's efficacy against penicillin-resistant and oxacillin-resistant methicillin-resistant strains is due to its high resistance to exonuclease and β-lactamase.
Activity against Gram-Positive Bacteria
- Aztreonam's activity against S.pneumoniae, Staphylococcus aureus, and Streptococcus pyogenes is mediated by a narrow group of gonococcal plasmid genes that encode aztreonam.
β-Lactam Antimicrobials
- The class of β-lactam antimicrobials includes penicillins, cephalosporins, carbapenems, monobactams, and β-lactamase inhibitors like clavulanic acid, sulbactam, and tazobactam.
- These drugs are used to treat infections caused by both Gram-positive and Gram-negative bacteria.
- They contain a four-atom β-lactam ring in their molecular structure, which is responsible for their antimicrobial activities.
Quiz about the use of aztreonam in veterinary medicine and its relation to beta-lactam antibiotics and cross-resistances. Covers the difference between aztreonam and other beta-lactam antibiotics like ampicillin and amoxicillin.
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