Aztrenom and Veterinary Medicine

What is the probable reason for aztreonam not contributing to cross-resistances in free amino group β-lactam antibiotics, aminopenicillins, and first-generation aminopenicillins?

What is the characteristic of monobactams that distinguishes them from other β-lactam antibiotics?

What is the mechanism by which aztreonam mediates its activity against certain bacteria?

What is the common structural feature of β-lactam antimicrobials?

What is the class of β-lactam antimicrobials that includes aztreonam?

What is the primary use of aztreonam?

What is the significance of aztreonam's high resistance to both exonuclease and β-lactamase?

What is the common target of β-lactam antimicrobials?

Aztreonam and β-Lactam Antibiotics

Aztreonam is not used in veterinary medicine, so it is unlikely to have contributed to cross-resistance in β-lactam antibiotics.
Contaminations in registered feed products are due to technological or cross-contaminations during manufacturing, not from the use of aztreonam.

Monobactams

Monobactams are a separate class of β-lactam antibiotics, semi-synthetic and monocyclic, unlike penicillins, cephalosporins, and carbapenems.
Aztreonam is the only commercially available β-lactam compound, used as a last-resort antibiotic against gram-negative bacteria.
Aztreonam's efficacy against penicillin-resistant and oxacillin-resistant methicillin-resistant strains is due to its high resistance to exonuclease and β-lactamase.

Activity against Gram-Positive Bacteria

Aztreonam's activity against S.pneumoniae, Staphylococcus aureus, and Streptococcus pyogenes is mediated by a narrow group of gonococcal plasmid genes that encode aztreonam.

β-Lactam Antimicrobials

The class of β-lactam antimicrobials includes penicillins, cephalosporins, carbapenems, monobactams, and β-lactamase inhibitors like clavulanic acid, sulbactam, and tazobactam.
These drugs are used to treat infections caused by both Gram-positive and Gram-negative bacteria.
They contain a four-atom β-lactam ring in their molecular structure, which is responsible for their antimicrobial activities.

Quiz about the use of aztreonam in veterinary medicine and its relation to beta-lactam antibiotics and cross-resistances. Covers the difference between aztreonam and other beta-lactam antibiotics like ampicillin and amoxicillin.