Annexe: Axonal Guidance Mechanisms

Which of the following molecules are not a part of the dorsal guidance system?

What type of signal is Shh during the axonal guidance process?

What is the role of the floor plate in axonal guidance?

What is the purpose of axonal crossing?

What does Sfrp do in the context of axonal guidance?

How does Shh modulate Wnt activity?

Which of the following molecules are involved in the guidance of commissural axons towards the floor plate?

Which molecule binds to Robo1 in preference to N-Slit in the absence of Dscam?

What role does FLRT3 play in thalamocortical axon guidance?

How does the expression of FLRT3 and Robo1 influence the response of thalamocortical axons to netrin?

Which of the following molecules is NOT involved in the guidance of thalamocortical axons?

What is the role of Sema3B and Npn-2 in axon guidance?

What is the significance of the observed difference in axonal behaviour in the presence of netrin versus the combination of netrin and Slit?

Which of the following statements about Robo1 is TRUE?

Which of the following is a key reason for the complexity of neural circuits?

Which of the following molecules has been identified as an alternative receptor for Slit?

How does Shh influence Wnt signaling?

Which of the following molecules is NOT directly involved in the guidance of commissural axons towards the floor plate?

How does Robo3 modulate the attraction of axons by netrin?

Which protein directly interacts with Sema6A to modulate its repulsive response?

In which of the following scenarios does Sfrp play a role?

What is the primary function of the molecule FLRT3 during axonal guidance?

What is the role of the molecule Sonic Hedgehog (Shh) in axonal guidance?

Which of the following is NOT a known mechanism of crosstalk between different axon guidance receptors?

Which of the following pathways involves a synergistic interaction between netrin and Shh?

Which of the following molecules functions as a receptor for Netrin-1 in commissural axon pathfinding?

Which mechanism is responsible for the sorting of axons in the optic tract by the molecule Hermes?

What is the role of RNA-binding proteins in axonal guidance?

Which of the following molecules is directly involved in commissure formation in the mammalian forebrain?

Which molecule acts as a gatekeeper between the central and peripheral nervous systems?

What is the role of Ryk in axonal guidance?

Which of the following molecules is involved in the regulation of Drosophila brain wiring?

What is the main function of the Frazzled/DCC receptor in axon guidance?

What is the role of Nectin-like molecules/SynCAMs in axonal guidance?

Which of the following proteins is a negative regulator of Slit responsiveness?

Which of the following molecules is required for the growth and guidance of mouse retinal ganglion cell axons?

What is a significant challenge when studying axonal guidance during embryonic development in mammals?

In what aspect of axonal guidance research does in vitro experimentation fall short?

Which of the following techniques is becoming increasingly useful for visualizing the relationship between surface receptors and the cytoskeleton?

What is the primary reason why diverse animal models are important for studying axonal guidance?

How does the research by Bourikas et al. (2005) contribute to our understanding of axonal guidance?

Based on the discussions, how does the research by Brignani and Pasterkamp (2017) relate to understanding axonal guidance?

What is a key takeaway from the research by Brittis et al. (2002) regarding axonal guidance?

The research by Bron et al. (2007) focuses on which aspect of axonal guidance?