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What factor is significantly influenced by the degree of crystallinity in drug delivery systems using CSNPs?

  • Rate of drug absorption
  • Particle size distribution
  • Chemical properties of the polymer
  • Hydrophilicity and hydrophobicity balance (correct)
  • Which of the following strategies increases the adsorption capacity of CSNPs?

  • Decreasing the molecular weight
  • Eliminating the sugar groups
  • Reducing the number of amine groups
  • Increasing the content of amine groups (correct)
  • How does surface roughness of nanoparticles affect their interaction with blood proteins?

  • It decreases the binding efficiency.
  • It increases concentration and interaction with proteins. (correct)
  • It has no effect on protein interaction.
  • It enhances drug absorption.
  • What is one consequence of the cationic nature of CSNPs in drug delivery applications?

    <p>Enhanced drug absorption through negative interactions.</p> Signup and view all the answers

    What mechanism primarily controls the drug release from CSNPs?

    <p>Degradation and diffusion of the polymer.</p> Signup and view all the answers

    In the context of CSNPs, what effect does increasing molecular weight generally have?

    <p>Increases polymolecularity and hydrophilicity.</p> Signup and view all the answers

    Which manufacturing method involves the cross-linking of chitosan chains for CSNP production?

    <p>Ionic gelation method.</p> Signup and view all the answers

    What is the influence of crystallinity on drug release from polymers?

    <p>Higher crystallinity results in low flexibility and slower drug diffusion.</p> Signup and view all the answers

    Which factor primarily determines the physicochemical properties of a polymer?

    <p>Degree of crystallinity</p> Signup and view all the answers

    What primarily determines the breakdown of polymer structures in drug delivery systems?

    <p>Ratio of hydrophobic to hydrophilic qualities.</p> Signup and view all the answers

    What condition describes a polymer when it is in a 'rubberlike' state?

    <p>It is above the glass transition temperature.</p> Signup and view all the answers

    Which statement is true regarding the manufacturing methods of CSNPs?

    <p>CSNPs can be created using various synthesis techniques that influence their properties.</p> Signup and view all the answers

    How does particle size impact the release profile of drugs from polymers?

    <p>Smaller particles increase the surface area for drug release.</p> Signup and view all the answers

    What is a common mechanism for polymer erosion?

    <p>Solvent penetration leading to swelling and degradation.</p> Signup and view all the answers

    Which transition is described as a β relaxation transition in polymers?

    <p>When transitioning occurs between 140 and 150 degrees Celsius.</p> Signup and view all the answers

    What effect do nano-fillers have on the glass transition temperature of polymers?

    <p>They decrease the glass transition temperature by developing free surfaces.</p> Signup and view all the answers

    What is the primary characteristic of bi-phasic drug release?

    <p>It helps achieve rapid therapeutic levels while maintaining controlled release.</p> Signup and view all the answers

    How does the diameter of CSNPs affect their behavior?

    <p>Smaller diameters increase surface area and decrease drug release path length.</p> Signup and view all the answers

    Which mechanism is NOT typically involved in drug release from polymer matrices?

    <p>Crosslinking of drug molecules</p> Signup and view all the answers

    What factor influences the selection of a manufacturing method for CSNPs?

    <p>The required particle size and stability</p> Signup and view all the answers

    In which method is crosslinking primarily achieved by hydrogen bonding?

    <p>Ionic gelation method</p> Signup and view all the answers

    What impact does the modification of CSNPs have on drug release rates?

    <p>It can lead to faster release rates compared to unconjugated CSNPs.</p> Signup and view all the answers

    Which of the following mathematical models is NOT used for kinetic analysis of drug release?

    <p>Logarithmic decay model</p> Signup and view all the answers

    What is the primary effect of pH on drug release from CSNPs?

    <p>It affects the solubility of the drug.</p> Signup and view all the answers

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