Autosomal Dominant Inheritance Patterns Quiz
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Questions and Answers

In autosomal dominant inheritance, what is the chance of an affected parent passing the affected allele to their offspring?

  • 75%
  • 50% (correct)
  • 100%
  • 25%

Which disorder is caused by a mutation in the low-density lipoprotein receptor?

  • Marfan syndrome
  • Achondroplasia
  • Hypercholesterolemia (correct)
  • Huntington disease type 2

What is the likely genotype of affected individuals in autosomal dominant inheritance?

  • AA
  • Not determinable
  • aa
  • Aa (correct)

Which type of inheritance pattern has an equal likelihood of both sexes being affected?

<p>Autosomal recessive inheritance (D)</p> Signup and view all the answers

What is the cause of Tuberous sclerosis?

<p>Mutations in the TSC1 and TSC2 genes (B)</p> Signup and view all the answers

Which genetic disorder is caused by mutations in the NF1 gene?

<p>Neurofibromatosis, type 1 (NF1) (A)</p> Signup and view all the answers

In mitochondrial inheritance, why are all children of an affected female expected to express the disease?

<p>Because mitochondrial DNA is only inherited from the mother, leading to 100% penetrance in all children. (D)</p> Signup and view all the answers

What is the characteristic of X-linked dominant disorders that leads to affected males not passing the disease to their sons?

<p>The fact that males are hemizygous for genes on the X chromosome. (C)</p> Signup and view all the answers

Why do generations may be skipped in the expression of X-linked recessive disorders if all offspring are heterozygotes?

<p>Because of the random inactivation of X chromosomes in females. (A)</p> Signup and view all the answers

What causes Albinism, a rare autosomal recessive disorder?

<p>Loss of melanocyte tyrosinase (A)</p> Signup and view all the answers

Which disorder is caused by mutations in a specific collagen gene and follows an X-linked recessive inheritance pattern?

<p>Alport syndrome (A)</p> Signup and view all the answers

What is the likelihood of an individual being a carrier of Albinism, an autosomal recessive disorder?

<p>1 in 2 (B)</p> Signup and view all the answers

Why do sons and daughters both have a 50% chance of inheriting the mutated allele from their mothers in X-linked recessive disorders?

<p>Because males are hemizygous for genes on the X chromosome. (B)</p> Signup and view all the answers

Why will affected males not pass an X-linked dominant disorder to their sons?

<p>Males are hemizygous for genes on the X chromosome. (D)</p> Signup and view all the answers

"Hypophosphatemic rickets" is a disorder caused by mutations in which type of inheritance pattern?

<p>X-linked dominant inheritance (A)</p> Signup and view all the answers

What characteristic feature leads to mitochondrial disorders being maternally inherited?

<p>Inheritance of mitochondria only from the mother (C)</p> Signup and view all the answers

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