Autosomal Dominant Inheritance Patterns Quiz

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In autosomal dominant inheritance, what is the chance of an affected parent passing the affected allele to their offspring?

50%

Which disorder is caused by a mutation in the low-density lipoprotein receptor?

Hypercholesterolemia

What is the likely genotype of affected individuals in autosomal dominant inheritance?

Aa

Which type of inheritance pattern has an equal likelihood of both sexes being affected?

<p>Autosomal recessive inheritance</p> Signup and view all the answers

What is the cause of Tuberous sclerosis?

<p>Mutations in the TSC1 and TSC2 genes</p> Signup and view all the answers

Which genetic disorder is caused by mutations in the NF1 gene?

<p>Neurofibromatosis, type 1 (NF1)</p> Signup and view all the answers

In mitochondrial inheritance, why are all children of an affected female expected to express the disease?

<p>Because mitochondrial DNA is only inherited from the mother, leading to 100% penetrance in all children.</p> Signup and view all the answers

What is the characteristic of X-linked dominant disorders that leads to affected males not passing the disease to their sons?

<p>The fact that males are hemizygous for genes on the X chromosome.</p> Signup and view all the answers

Why do generations may be skipped in the expression of X-linked recessive disorders if all offspring are heterozygotes?

<p>Because of the random inactivation of X chromosomes in females.</p> Signup and view all the answers

What causes Albinism, a rare autosomal recessive disorder?

<p>Loss of melanocyte tyrosinase</p> Signup and view all the answers

Which disorder is caused by mutations in a specific collagen gene and follows an X-linked recessive inheritance pattern?

<p>Alport syndrome</p> Signup and view all the answers

What is the likelihood of an individual being a carrier of Albinism, an autosomal recessive disorder?

<p>1 in 2</p> Signup and view all the answers

Why do sons and daughters both have a 50% chance of inheriting the mutated allele from their mothers in X-linked recessive disorders?

<p>Because males are hemizygous for genes on the X chromosome.</p> Signup and view all the answers

Why will affected males not pass an X-linked dominant disorder to their sons?

<p>Males are hemizygous for genes on the X chromosome.</p> Signup and view all the answers

"Hypophosphatemic rickets" is a disorder caused by mutations in which type of inheritance pattern?

<p>X-linked dominant inheritance</p> Signup and view all the answers

What characteristic feature leads to mitochondrial disorders being maternally inherited?

<p>Inheritance of mitochondria only from the mother</p> Signup and view all the answers

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