Autonomic Nervous System

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Questions and Answers

What bodily function does the autonomic nervous system (ANS) primarily regulate?

  • Voluntary movements of skeletal muscles
  • Vital bodily functions through innervation of visceral smooth muscle, cardiac muscle, vasculature, and exocrine glands (correct)
  • Sensory information processing
  • Direct conscious control of bodily activities

If an individual is experiencing a "fight or flight" response, which of the following physiological changes would be LEAST likely to occur?

  • Increased blood flow to skeletal muscles
  • Increased heart rate and blood pressure
  • Dilation of pupils and bronchioles
  • Increased digestion activity (correct)

How do preganglionic neurons of the sympathetic nervous system connect with the adrenal medulla, and what is the result of this connection?

  • Preganglionic neurons inhibit the adrenal medulla, reducing the production of stress hormones.
  • Preganglionic neurons bypass the adrenal medulla, directly affecting target organs.
  • Preganglionic neurons synapse directly within the adrenal medulla, causing the release of epinephrine and norepinephrine. (correct)
  • Preganglionic neurons connect indirectly via a ganglion, stimulating the release of acetylcholine.

Which cranial nerve accounts for the majority of preganglionic parasympathetic fibers in the body?

<p>Vagus nerve (X) (B)</p> Signup and view all the answers

What is the primary role of acetylcholinesterase (AChE) in the synaptic cleft?

<p>Cleavage of acetylcholine into choline and acetate (A)</p> Signup and view all the answers

The enteric nervous system (ENS) is modulated by which components of the nervous system?

<p>Both the sympathetic and parasympathetic nervous systems (C)</p> Signup and view all the answers

Where are muscarinic receptors NOT found?

<p>Skeletal muscles at the neuromuscular junction (C)</p> Signup and view all the answers

What is the primary mechanism of action of indirect-acting cholinergic agonists?

<p>Preventing the degradation of acetylcholine in the synaptic space (A)</p> Signup and view all the answers

Which of the following is a potential adverse effect associated with muscarinic stimulation?

<p>Bradycardia (A)</p> Signup and view all the answers

A patient presents with symptoms of muscarinic excess: increased salivation, lacrimation, urination, defecation and gastrointestinal distress. Which medication could be used to treat this?

<p>Atropine (C)</p> Signup and view all the answers

Which of the following characteristics distinguishes nicotinic receptors of the autonomic ganglia (N\u208N) from those at the neuromuscular junction (Nâ‚‘)?

<p>They bind acetylcholine with different affinities. (C)</p> Signup and view all the answers

Which of the following is a key difference between atropine and scopolamine concerning their effects on the central nervous system (CNS)?

<p>Scopolamine has a greater effect on the CNS than atropine. (D)</p> Signup and view all the answers

Which condition is NOT typically treated with antimuscarinic medications?

<p>Glaucoma (B)</p> Signup and view all the answers

A patient exhibits the following symptoms: dry mouth, blurred vision, tachycardia, and restlessness. Which type of drug overdose is most likely causing these symptoms?

<p>Cholinergic antagonist (A)</p> Signup and view all the answers

Which of the following best describes the primary action of anticholinergic drugs on muscarinic receptors?

<p>They bind to muscarinic receptors but do not activate them, preventing acetylcholine binding. (B)</p> Signup and view all the answers

What is the physiological basis for the use of atropine in treating toxicity from organophosphate insecticides?

<p>Atropine blocks muscarinic receptors, counteracting the excessive cholinergic stimulation caused by organophosphates. (D)</p> Signup and view all the answers

What is the primary effect of pilocarpine on the eye, and why is this clinically relevant?

<p>Miosis; it lowers intraocular pressure, making it useful in glaucoma management. (D)</p> Signup and view all the answers

How does botulinum toxin affect neurotransmission at cholinergic neurons?

<p>It blocks the release of acetylcholine. (D)</p> Signup and view all the answers

A researcher is studying the effects of a drug on the autonomic nervous system. They observe that the drug increases heart rate, dilates pupils, and reduces digestion. Which branch of the autonomic nervous system is most likely being stimulated by this drug?

<p>Sympathetic nervous system (C)</p> Signup and view all the answers

A patient with chronic obstructive pulmonary disease (COPD) is prescribed tiotropium. How does tiotropium alleviate the symptoms of COPD?

<p>By blocking muscarinic receptors in the airways (B)</p> Signup and view all the answers

Which of the following is the primary mechanism by which atropine exerts its effects?

<p>Blocking muscarinic acetylcholine receptors (D)</p> Signup and view all the answers

Which of the following responses is NOT a direct effect of sympathetic nervous system activation?

<p>Increased digestion (C)</p> Signup and view all the answers

A patient is experiencing memory impairment and cognitive decline. A medication that increases acetylcholine levels in the CNS is being considered. Which of the following mechanisms of action would be most appropriate for such a medication?

<p>Acetylcholinesterase inhibitor (A)</p> Signup and view all the answers

How do preganglionic neurons in the parasympathetic nervous system differ structurally from those in the sympathetic nervous system?

<p>Parasympathetic preganglionic neurons are longer and synapse in ganglia near or on the effector organs. (C)</p> Signup and view all the answers

Which type of cholinergic receptor is primarily found at the neuromuscular junction in skeletal muscle?

<p>NM nicotinic receptors (D)</p> Signup and view all the answers

What process is inhibited by hemicholinium?

<p>Uptake of choline into the neuron (A)</p> Signup and view all the answers

What is the mechanism of action of physostigmine?

<p>Inhibits acetylcholinesterase (D)</p> Signup and view all the answers

Which of the listed responses is the result of M3 receptor activation?

<p>Smooth muscle contraction (A)</p> Signup and view all the answers

What effect does bethanechol have?

<p>Stimulates secretion and contraction of intestinal smooth muscle (A)</p> Signup and view all the answers

Which class of medication is tiotropium?

<p>Long acting muscarinic antagonist (C)</p> Signup and view all the answers

What is the method classification of cholinergic agonist drugs?

<p>If they directly or indirectly activate cholinoceptors (B)</p> Signup and view all the answers

Which is not a therapeutic use for Pilocarpine?

<p>Mydriasis (A)</p> Signup and view all the answers

If a patient takes pilocarpine, what mechanism will provide the therapeutic effects?

<p>Contraction of the pupillary sphincter (B)</p> Signup and view all the answers

What is an effect of Atropine being administered?

<p>Tachycardia (B)</p> Signup and view all the answers

Administration of what will negate the effects of severe cardio or bronchoconstrictor responses?

<p>Atropine Sulfate (D)</p> Signup and view all the answers

What would be the primary use of someone adminsitering Scopolamine?

<p>Prevention of vomiting (A)</p> Signup and view all the answers

What physiological change is caused by the administration of anticholinergics?

<p>Urinary retention (A)</p> Signup and view all the answers

What mechanism involves atropine's effects?

<p>Muscarinic (B)</p> Signup and view all the answers

What is not a known side effect of atropine?

<p>Increased salivation (A)</p> Signup and view all the answers

The autonomic nervous system is divided into which branches?

<p>Sympathetic and Parasympathetic (D)</p> Signup and view all the answers

Flashcards

Somatic Nervous System

The division of the peripheral nervous system that controls voluntary movements like muscle contractions.

Autonomic Nervous System (ANS)

The division that controls involuntary functions like digestion, heart rate, and glandular secretions.

Preganglionic Neurons

Emerge from the brainstem or spinal cord and make a synaptic connection.

Ganglia

An aggregation of nerve cell bodies located in the peripheral nervous system

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Postganglionic Neurons

Originate in the ganglion and terminate on effector organs.

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Sympathetic Nervous System

Division of the ANS responsible for fight or flight responses, increases heart rate and blood pressure.

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Parasympathetic Nervous System

Division of the ANS responsible for the rest and digest functions, maintains homeostasis.

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Enteric Nervous System (ENS)

Innervates the GI tract, pancreas, and gallbladder; sometimes called the 'brain of the gut'.

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Adrenergic Receptors

Receptors that bind to epinephrine (EP) and norepinephrine (NE).

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Cholinergic Receptors

Receptors that bind to acetylcholine (ACh).

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Cholinergic Receptor Location

Found at autonomic ganglia, adrenal medulla, parasympathetic postganglionic nerves, and neuromuscular junctions.

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Muscarinic Receptors

One of the two main types of cholinergic receptors; high affinity to muscarine.

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Nicotinic Receptors

One of the two main types of cholinergic receptors; binds to nicotine.

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Cholinomimetics

Cholinergic drugs that mimic the action of acetylcholine.

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Direct-Acting Cholinergic Agonists

Bind and activate the receptor directly.

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Bethanechol

Acetylcholine receptor agonist that increases intestinal motility and tone; stimulates urination.

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Pilocarpine

Acetylcholine receptor agonist that produces rapid miosis, and treats glaucoma.

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Indirect-Acting Cholinergic Agonists

Increase ACh levels by preventing its degradation.

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Physostigmine

Can penetrate the CNS, used as antidote for poisoning caused by anticholinergics.

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Neostigmine

Cannot penetrate the CNS, used for reversal of neuromuscular blockade after surgery.

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Cholinergic Antagonists

Block cholinoceptors, preventing effects of acetylcholine.

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Antimuscarinics

Blocks muscarinic receptors, inhibiting muscarinic functions.

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Atropine Actions

Relieves spasms, reduces secretions, dilates pupils.

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Scopolamine

Has CNS action, works on the vomiting center in the brain, and can block short term memory

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Anticholinergic Toxicity Symptoms

Dry as a bone, red as a beet, mad as a hatter, hot as a desert.

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Bronchodilators Use

Maintenance treatment of brionchospasm associated with COPD.

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Study Notes

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