Pharma - Berto - L7 part 1
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Pharma - Berto - L7 part 1

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Questions and Answers

Which division of the peripheral nervous system is primarily responsible for voluntary movements?

  • Autonomic nervous system
  • Somatic nervous system (correct)
  • Sympathetic nervous system
  • Parasympathetic nervous system

    • What is the primary function of the autonomic nervous system (ANS)?

  • Facilitate communication between neurons
  • Regulate involuntary bodily functions (correct)
  • Transmit sensory information
  • Control voluntary muscle movements

    • In which part of the brain is the superior control of the ANS located?

  • Thalamus
  • Cerebral cortex
  • Limbic system
  • Brainstem (correct)

    • Which physiological functions are regulated by the centers in the hypothalamus?

    <p>Respiration and heart rate</p> Signup and view all the answers

    What typical response is associated with the activation of the sympathetic nervous system?

    <p>Fight or flight response</p> Signup and view all the answers

    How do the sympathetic and parasympathetic systems interact to maintain homeostasis?

    <p>They have opposing effects that maintain a dynamic equilibrium.</p> Signup and view all the answers

    Individuals whose sympathetic nervous system activity prevails may exhibit which of the following characteristics?

    <p>Higher blood pressure</p> Signup and view all the answers

    What role does the autonomic nervous system play in relation to the endocrine system?

    <p>The ANS engages in crosstalk that is essential for survival.</p> Signup and view all the answers

    Which of the following describes the autonomic reflexes?

    <p>They primarily serve to maintain homeostasis.</p> Signup and view all the answers

    What is the primary role of the sympathetic nervous system?

    <p>Response to stressful conditions</p> Signup and view all the answers

    Which of the following effects is associated with the parasympathetic nervous system?

    <p>Increased salivary secretion</p> Signup and view all the answers

    Which neurotransmitter is responsible for the postganglionic action in the sympathetic nervous system?

    <p>Noradrenaline</p> Signup and view all the answers

    How does the sympathetic nervous system affect blood pressure during stress?

    <p>Increases it through generalized vasoconstriction</p> Signup and view all the answers

    What differentiates the receptors utilized by the sympathetic and parasympathetic nervous systems?

    <p>Nicotinic receptors act for both systems at preganglionic level</p> Signup and view all the answers

    What type of drug acts on the neurotransmitter signaling system by mimicking its action?

    <p>Agonist</p> Signup and view all the answers

    Which of the following statements about the anatomy of the autonomic nervous system is correct?

    <p>The preganglionic fibers of the parasympathetic system are longer than those of the sympathetic system.</p> Signup and view all the answers

    Which physiological effect is induced by the sympathetic nervous system during a stressful situation?

    <p>Mydriasis for enhanced distance vision</p> Signup and view all the answers

    What is the physiological role of the adrenal medulla in relation to the sympathetic nervous system?

    <p>It releases hormones directly into the bloodstream.</p> Signup and view all the answers

    Which receptor subtype is responsible primarily for bronchodilation and uterine relaxation?

    <p>β2 receptor</p> Signup and view all the answers

    What is the primary effect of α1 adrenergic receptors on vascular smooth muscle?

    <p>Vasoconstriction</p> Signup and view all the answers

    In which organ are β1 receptors mainly found, and what is their primary function?

    <p>Heart; increase in contraction strength</p> Signup and view all the answers

    Which adrenergic receptor subtype is classified as an autoreceptor and serves by providing negative feedback?

    <p>α2 receptor</p> Signup and view all the answers

    What mechanism does the β2 receptor use to achieve muscle relaxation in the bronchi?

    <p>Activation of protein kinase A leading to MLCK inactivation</p> Signup and view all the answers

    Which of the following G proteins are α1 receptors coupled with?

    <p>Gq protein</p> Signup and view all the answers

    What is the main effect of β3 adrenergic receptors when activated?

    <p>Lipolysis in adipose tissue</p> Signup and view all the answers

    What neurotransmitter is synthesized from Acetyl-CoA and is involved in cholinergic signaling?

    <p>Acetylcholine</p> Signup and view all the answers

    Which drug type can inhibit acetylcholinesterase, thereby prolonging the action of acetylcholine at the synapse?

    <p>Acetylcholine esterase inhibitors</p> Signup and view all the answers

    What is the role of the catalytic subunit of PKA in the action of β1 receptors in cardiac tissue?

    <p>Phosphorylates calcium channels to increase influx</p> Signup and view all the answers

    Study Notes

    Peripheral Nervous System Overview

    • Efferent section comprises autonomic and somatic nervous systems.
    • Somatic nervous system controls voluntary movements involving striated muscle.
    • Autonomic nervous system (ANS) regulates involuntary responses, functioning without conscious control.

    Autonomic Nervous System (ANS)

    • Superior control of ANS is located in the brainstem, integrating with hypothalamus and other brain areas.
    • Homeostatic centers manage essential physiological functions: respiration, heart rate, blood pressure, body temperature, and hunger.
    • ANS subdivided into parasympathetic and sympathetic systems, opposing each other in function.

    Sympathetic System

    • Activated during stress (fight or flight response).
    • Increases heart rate, blood pressure through vasoconstriction, and mobilizes energy stores.
    • Directs blood flow towards skeletal muscles and stimulates adrenal medulla for adrenaline release.
    • Reduces gastrointestinal (GI) activity, causing symptoms like dry mouth.
    • Causes mydriasis (pupil dilation) for better vision under stress.

    Parasympathetic System

    • Promotes "rest and digest," maintaining essential bodily functions.
    • Decreases heart rate and blood pressure through vasodilation.
    • Enhances GI motility and secretion, facilitates bladder and rectum emptying, and induces sialorrhea (saliva production).
    • Causes miosis (pupil constriction) for close vision.

    Balance Between Systems

    • Homeostasis relies on a dynamic balance between sympathetic and parasympathetic activities.
    • Individuals may lean towards one system, affecting characteristics like irritability or weight.

    Relationship with Endocrine System

    • ANS and endocrine system exhibit close interaction, vital for survival.
    • Sympathetic system evolutionarily developed first, crucial for immediate survival needs.

    Neurotransmitters and Receptors

    • Somatic system utilizes acetylcholine (ACh) with nicotinic receptors for striated muscle control.
    • ANS uses acetylcholine for preganglionic transmission; postganglionic output varies:
      • Parasympathetic: acetylcholine with muscarinic receptors.
      • Sympathetic: noradrenaline with adrenergic receptors (α and β).

    Pharmacological Aspects

    • Targeting the ANS includes four types of drugs: agonists and antagonists for sympathetic and parasympathetic systems.
    • Actions can modulate neurotransmitter synthesis, reuptake, and receptor activities.

    Adrenergic Receptors

    • Five subtypes exist; key ones include:
      • α1: vasoconstriction, increased pressure, glycogenolysis.
      • β1: increases heart rate and contractility, mediates renin release.
      • β2: promotes bronchodilation and relaxation in various tissues, critical under stress.
      • β3: induces lipolysis in adipose tissue.

    Cholinergic System

    • Acetylcholine synthesized from Acetyl-CoA, regulated by specific enzymes.
    • Acetylcholine breakdown facilitated by acetylcholinesterase.
    • Drugs affecting cholinergic activity can include inhibitors like neostigmine and toxins affecting neurotransmitter release.

    Summary

    • The peripheral nervous system plays a crucial role in regulating both voluntary and involuntary bodily functions.
    • ANS maintains balance between sympathetic and parasympathetic responses, essential for homeostasis and survival.

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    Description

    Explore the divisions of the efferent section of the peripheral nervous system in this quiz based on Bertocchi L.07. Learn about the somatic and autonomic nervous systems, their functions, and involuntary versus voluntary movements. Test your knowledge of how these systems interact with our sensory experiences.

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