Autonomic Nervous System: Adrenergics
76 Questions
2 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What are the primary adrenergic receptors that α-blockers target to achieve their effects?

  • α1- and α2-receptors (correct)
  • β1- and β2-receptors
  • γ-receptors and δ-receptors
  • β-antagonists only

Which of the following describes a common therapeutic effect of adrenergic blockers?

  • Decreased peripheral vascular resistance (correct)
  • Elevated blood pressure
  • Increased urinary obstruction
  • Increased heart rate

What is the indication for using α-blockers in patients with benign prostatic hyperplasia (BPH)?

  • Releasing norepinephrine
  • Enhancing smooth muscle contractions
  • Increasing resistance to urinary flow
  • Decreasing urinary obstruction (correct)

Which of the following is a potential adverse effect associated with the use of α-blockers?

<p>Chest pain (B)</p> Signup and view all the answers

How do β-blockers primarily affect the cardiovascular system?

<p>Inhibit cardiac contractility (A)</p> Signup and view all the answers

Which of the following effects can result from the blockade of α1-adrenergic receptors?

<p>Increased urine output (A)</p> Signup and view all the answers

What is an expected outcome after treating a patient with adrenergic blockers?

<p>Improved skin color and temperature (A)</p> Signup and view all the answers

Which of the following adrenergic blockers can cause dizziness and anxiety as adverse effects?

<p>α1-blockers like doxazosin and prazosin (A)</p> Signup and view all the answers

Which of the following statements correctly describes α1-adrenergic receptors?

<p>They are located on postsynaptic effector cells. (A)</p> Signup and view all the answers

Which of the following terms refers to substances that can mimic the effects of the sympathetic nervous system?

<p>Adrenergic agonists (C)</p> Signup and view all the answers

What is the primary location of β1-adrenergic receptors in the body?

<p>Heart (D)</p> Signup and view all the answers

Which adrenergic agonist is primarily used for its vasopressor effects in critical care settings?

<p>Epinephrine (D)</p> Signup and view all the answers

What is a common adverse effect associated with adrenergic drug therapy?

<p>Increased heart rate (D)</p> Signup and view all the answers

Which mechanism of action involves stimulating receptors directly to elicit a physiological response?

<p>Direct-acting sympathomimetic (B)</p> Signup and view all the answers

What role do presynaptic α2-adrenergic receptors play in neurotransmitter regulation?

<p>They inhibit neurotransmitter release. (B)</p> Signup and view all the answers

Which drug is classified as a synthetic adrenergic agonist?

<p>Dobutamine (A)</p> Signup and view all the answers

What is a common use for α-adrenergic receptor agonists?

<p>Treatment of open-angle glaucoma (C)</p> Signup and view all the answers

Which of the following is an example of a nonselective adrenergic agonist?

<p>Epinephrine hydrochloride (A)</p> Signup and view all the answers

Which adverse effect is most commonly associated with β-adrenergic receptor agonists?

<p>Chest pain (C)</p> Signup and view all the answers

What is the primary action of norepinephrine?

<p>Vasoconstriction and increased contractility (B)</p> Signup and view all the answers

Dopamine at low doses primarily affects which type of receptor activity?

<p>Dopaminergic (A)</p> Signup and view all the answers

Which sympathomimetic drug is primarily used to support the heart during cardiac failure?

<p>Dobutamine (C)</p> Signup and view all the answers

What is a significant interaction concern for patients on adrenergic drugs?

<p>Antihistamines (C)</p> Signup and view all the answers

Which condition is most likely treated with cutaneous diversion of α-adrenergic drugs?

<p>Open-angle glaucoma (A)</p> Signup and view all the answers

What common adverse reaction is associated with both α- and β-adrenergic receptor agonists?

<p>Tachycardia (D)</p> Signup and view all the answers

Which of the following drugs is used to treat hypotension and shock?

<p>Norepinephrine (B)</p> Signup and view all the answers

Which type of sympathomimetic drug directly binds to adrenergic receptors to elicit a physiological response?

<p>Direct-acting sympathomimetic (C)</p> Signup and view all the answers

Which adrenergic receptor subtype is primarily located on presynaptic nerve terminals?

<p>α2-Adrenergic receptor (D)</p> Signup and view all the answers

Which synthetic sympathomimetic drug is commonly used to manage cardiac issues?

<p>Dobutamine (D)</p> Signup and view all the answers

What is the main physiological outcome when activating ß2-adrenergic receptors?

<p>Bronchodilation (A)</p> Signup and view all the answers

Which of the following describes the mechanism of action of indirect-acting sympathomimetics?

<p>Release catecholamines from nerve endings (D)</p> Signup and view all the answers

What physiological effect occurs due to the stimulation of α-adrenergic receptors?

<p>Vasoconstriction of blood vessels (B)</p> Signup and view all the answers

Which of the following effects is NOT associated with the stimulation of ß1-adrenergic receptors?

<p>Uterine contraction (B)</p> Signup and view all the answers

Which potential adverse effect could result from the use of adrenergic agonists?

<p>Tachycardia (D)</p> Signup and view all the answers

What class of drugs is used to block the effects of the sympathetic nervous system?

<p>Adrenergic antagonists (A)</p> Signup and view all the answers

What is the primary therapeutic application of β2-adrenergic agonists?

<p>Relieving bronchospasm in asthma (B)</p> Signup and view all the answers

Which of the following interactions occurs with stimulation of ß2-adrenergic receptors?

<p>Uterine relaxation (D)</p> Signup and view all the answers

Which adrenergic agonist is primarily used for its vasopressor effects?

<p>Norepinephrine (C)</p> Signup and view all the answers

What effect does stimulation of α-adrenergic receptors in the eye have?

<p>Constriction of pupillary muscles (B)</p> Signup and view all the answers

Which of the following drugs is a common β2-selective adrenergic drug used for bronchodilation?

<p>Formoterol (D)</p> Signup and view all the answers

Which physiological response is primarily a result of stimulation of β1-adrenergic receptors?

<p>Increased heart rate (B)</p> Signup and view all the answers

What effect does stimulation of α-adrenergic receptors have on the bladder?

<p>Constriction of bladder sphincter (C)</p> Signup and view all the answers

What is the primary therapeutic use of α-blockers?

<p>To reduce urinary obstruction (A)</p> Signup and view all the answers

Which effect is NOT associated with α1-adrenergic receptor blockage?

<p>Smooth muscle contraction in the bladder neck (C)</p> Signup and view all the answers

What common side effect may occur as a result of α-blocker therapy?

<p>Dizziness (C)</p> Signup and view all the answers

Which classification includes drugs like doxazosin and terazosin?

<p>α-blockers (D)</p> Signup and view all the answers

Which condition is a contraindication for using α-blockers?

<p>Severe heart failure (D)</p> Signup and view all the answers

What is a primary contraindication for the use of tamsulosin?

<p>Concurrent use of erectile dysfunction drugs (B)</p> Signup and view all the answers

What physiological effect is achieved by α-blockers on blood vessels?

<p>Dilation of arteries and veins (C)</p> Signup and view all the answers

Which symptom may indicate the adverse effect of orthostatic hypotension in patients taking α-blockers?

<p>Lightheadedness upon standing (C)</p> Signup and view all the answers

Which effect results from the blockade of β2-adrenergic receptors by nonselective β-blockers?

<p>Bronchoconstriction (C)</p> Signup and view all the answers

What therapeutic effect do cardioselective β-blockers primarily provide?

<p>Decrease heart rate (C)</p> Signup and view all the answers

What is an expected therapeutic outcome when assessing a patient treated with adrenergic blockers?

<p>Decreased blood pressure (B)</p> Signup and view all the answers

What is one of the main adverse effects of using tamsulosin?

<p>Headache (B)</p> Signup and view all the answers

What could be a serious complication when using nonselective β-blockers?

<p>Shortness of breath (C)</p> Signup and view all the answers

What is a common indication for the use of β-blockers?

<p>Angina (C)</p> Signup and view all the answers

Which statement correctly describes the mechanism of action of nonselective β-blockers?

<p>They block β1 and β2 receptors, affecting both the heart and lungs. (D)</p> Signup and view all the answers

What effect do β-blockers have on blood pressure?

<p>Significantly decrease blood pressure (B)</p> Signup and view all the answers

Which of the following drugs is primarily used for the reduction of intraocular pressure in open-angle glaucoma?

<p>Dipivefrin hydrochloride (B)</p> Signup and view all the answers

What type of receptor activity does dopamine exhibit at low doses?

<p>Vasodilation in specific organs (B)</p> Signup and view all the answers

Which drug is administered in emergency situations as a prototypical nonselective adrenergic agonist?

<p>Epinephrine hydrochloride (A)</p> Signup and view all the answers

Which of the following is a possible adverse effect of adrenergic drugs?

<p>Hypertension (D)</p> Signup and view all the answers

Which of the following statements correctly describes the action of norepinephrine?

<p>It causes vasoconstriction without stimulating β2 receptors. (C)</p> Signup and view all the answers

What is a primary indication for using sympathomimetics like dobutamine?

<p>Cardiac failure or shock (D)</p> Signup and view all the answers

What potential interaction should be considered when administering adrenergic drugs?

<p>Tricyclic antidepressants (C)</p> Signup and view all the answers

Which of the following is an example of a drug that causes vasoconstriction?

<p>Epinephrine hydrochloride (A)</p> Signup and view all the answers

Which adverse effect is associated with β-adrenergic agonists?

<p>Chest pain (C)</p> Signup and view all the answers

What effect does dipivefrin hydrochloride primarily target in open-angle glaucoma treatment?

<p>Reduction of intraocular pressure (A)</p> Signup and view all the answers

What is a common therapeutic use of atenolol (Tenormin®)?

<p>Prevention of future heart attacks (B)</p> Signup and view all the answers

Which side effect is commonly associated with the use of β-blockers?

<p>Bradycardia (A)</p> Signup and view all the answers

What should be monitored in patients taking adrenergic-blocking drugs?

<p>Apical pulse and blood pressure (B)</p> Signup and view all the answers

How do β-blockers primarily exert their effects on the cardiovascular system?

<p>Through β1-receptor blockade (C)</p> Signup and view all the answers

Which of the following is a potential drug interaction concern for patients using adrenergic-blocking drugs?

<p>Antacids (aluminum hydroxide type) (D)</p> Signup and view all the answers

What is an essential nursing implication when administering β-blockers?

<p>Regularly assess for allergies and medical history (B)</p> Signup and view all the answers

Which β-blocker is known for its dual antihypertensive effects?

<p>Labatalol (C)</p> Signup and view all the answers

What effect can α-blockers potentially precipitate after the first dose?

<p>Hypotension (D)</p> Signup and view all the answers

Flashcards

Conjunctival congestion relief

Using drugs to reduce swelling in the membrane lining the eye.

α-adrenergic receptors

Specific receptors in the body that respond to certain hormones and neurotransmitters.

Vasoactive sympathomimetics

Drugs that affect blood vessels and the heart, often in cases of emergency or shock.

Dopamine (low dose)

Dilates blood vessels in the brain, heart, kidneys, and mesentery, increasing blood flow.

Signup and view all the flashcards

Dopamine (high dose)

Increases heart contractility and output.

Signup and view all the flashcards

Epinephrine (Adrenaline)

A natural hormone used in emergencies for various effects on the body, including vasoconstriction.

Signup and view all the flashcards

Norepinephrine (Levophed)

Stimulates α-adrenergic receptors (vasoconstriction) and affects the heart (β1).

Signup and view all the flashcards

β-adrenergic receptors

Specific receptors that regulate heart rate, blood flow, and other functions.

Signup and view all the flashcards

Adverse effects of α-adrenergic agonists

Can include headache, restlessness, palpitations, and hypertension.

Signup and view all the flashcards

Adverse effects of β-adrenergic agonists

Can include palpitations, tachycardia, and hypertension.

Signup and view all the flashcards

Adrenergic Blockers

Drugs that bind to adrenergic receptors, but block the stimulation of the sympathetic nervous system, having the opposite effect of adrenergic drugs.

Signup and view all the flashcards

α-blockers

A class of adrenergic blockers that target α1- and α2-receptors, causing both arterial and venous dilation, which reduces blood pressure.

Signup and view all the flashcards

α1-Blockers

Drugs that specifically block α1-adrenergic receptors, lowering blood pressure by dilating arteries and veins. They also improve urinary flow by relaxing bladder muscles.

Signup and view all the flashcards

Hypertension Treatment (α-blockers)

α-blockers, like doxazosin, prazosin, and terazosin, are used to treat high blood pressure.

Signup and view all the flashcards

Benign Prostatic Hyperplasia (BPH)

A condition involving an enlarged prostate gland, creating urinary outflow resistance.

Signup and view all the flashcards

Baseline Assessment

Assessment performed before a treatment to determine the patient's initial condition.

Signup and view all the flashcards

Therapeutic Effects Monitoring

Assessing the effectiveness of treatment by observing improvements like decreased edema, increased urine output, and improved vital signs.

Signup and view all the flashcards

Adverse Effects of α-Blockers

Potential side effects of α-blockers, including cardiovascular problems like orthostatic hypotension and tachycardia, as well as central nervous system, gastrointestinal, and other complications.

Signup and view all the flashcards

Adrenergic Agonists

Drugs that stimulate the sympathetic nervous system by mimicking the effects of natural neurotransmitters.

Signup and view all the flashcards

Catecholamines

A group of endogenous (naturally occurring) neurotransmitters that stimulate the sympathetic nervous system, including epinephrine, norepinephrine, and dopamine.

Signup and view all the flashcards

Direct-acting sympathomimetic

A type of adrenergic agonist that directly binds to and activates adrenergic receptors.

Signup and view all the flashcards

Sympathomimetic

A drug that mimics the effects of the sympathetic nervous system.

Signup and view all the flashcards

Indirect-acting sympathomimetic

A type of adrenergic agonist that causes the release of catecholamines from storage sites.

Signup and view all the flashcards

Sympathetic Nervous System (SNS)

Part of the autonomic nervous system that controls the body's 'fight or flight' response.

Signup and view all the flashcards

α-Adrenergic Receptors: Smooth Muscle Effects

Stimulating α-adrenergic receptors in smooth muscles leads to vasoconstriction (narrowing of blood vessels) and relaxation of the gastrointestinal (GI) tract, reducing its activity.

Signup and view all the flashcards

Sympathomimetic Effects: α-Adrenergic Receptors

Stimulating α-adrenergic receptors causes effects like constriction of the bladder sphincter (controlling urine flow), contraction of the uterus, male ejaculation, and dilation of pupils.

Signup and view all the flashcards

β1-Adrenergic Receptors: Cardiac Effects

β1-adrenergic receptors are located on the heart's myocardium, atrioventricular (AV) node, and sinoatrial node. Stimulating these receptors increases heart rate (chronotropic effect), force of contraction (inotropic effect), and conduction speed through the AV node (dromotropic effect).

Signup and view all the flashcards

β2-Adrenergic Receptors: Bronchodilation

Stimulating β2-adrenergic receptors in the airways causes bronchodilation (relaxation of the bronchi), making it easier to breathe.

Signup and view all the flashcards

Other Effects: β2-Adrenergic Stimulation

Besides bronchodilation, β2-adrenergic stimulation can also cause uterine relaxation, glycogen breakdown in the liver, increased renin secretion by the kidneys, and reduced activity in the GI tract.

Signup and view all the flashcards

Bronchodilators: Asthma and Bronchitis

Bronchodilators are medications that stimulate β2-adrenergic receptors in the bronchial smooth muscles, causing relaxation and opening up the airways. This is used to treat conditions like asthma and bronchitis.

Signup and view all the flashcards

Common Bronchodilators: β2-Selective

Several medications like formoterol, salbutamol, salmeterol, xinafoate, and terbutaline are classified as β2-selective adrenergic agonists. They stimulate β2-adrenergic receptors to cause bronchodilation.

Signup and view all the flashcards

β2-Selective Adrenergic Agonists: Indications

These β2-selective drugs are commonly used to treat asthma and bronchitis, as they effectively open up the airways, making it easier to breathe.

Signup and view all the flashcards

Adrenergic Blockers: What are they?

Drugs that block adrenergic receptors, inhibiting the sympathetic nervous system's stimulating effects. They essentially work against the effects of adrenaline and noradrenaline.

Signup and view all the flashcards

α-Blockers: How do they work?

These drugs specifically target α1- and α2-receptors, leading to dilation of both arteries and veins, reducing peripheral vascular resistance and blood pressure.

Signup and view all the flashcards

α1-Blockers: What are their benefits?

Lower blood pressure by dilating arteries and veins. Additionally, they improve urinary flow by relaxing bladder muscles, easing conditions like benign prostatic hyperplasia (BPH).

Signup and view all the flashcards

α-Blockers: What are their side effects?

Various side effects can occur, including cardiovascular problems (orthostatic hypotension, tachycardia), CNS effects (dizziness, headache), gastrointestinal issues, and other complications.

Signup and view all the flashcards

What are adrenergic receptors?

These are specialized receptors in the body that respond to certain hormones and neurotransmitters, particularly those involved in the sympathetic nervous system, like adrenaline and noradrenaline.

Signup and view all the flashcards

What is baseline assessment?

An initial evaluation done before treatment to determine the patient's current health status, vital signs, and any potential risks.

Signup and view all the flashcards

What are the therapeutic effects of adrenergic blockers?

These drugs are used to manage various conditions, but some common therapeutic effects in cardiovascular contexts include reduced edema, increased urine output, improved vital signs, and better skin color and temperature.

Signup and view all the flashcards

Why are cardiovascular conditions assessed before treatment?

It's crucial to understand a patient's existing heart and blood vessel health before starting treatment with medications that affect the cardiovascular system; potential risks and drug interactions must be considered.

Signup and view all the flashcards

Cardioselective β-Blockers

Beta blockers that primarily target beta-1 receptors in the heart, reducing heart rate and contractility without significantly affecting beta-2 receptors in the lungs.

Signup and view all the flashcards

Atenolol (Tenormin®)

A common cardioselective beta-blocker used to prevent future heart attacks, manage hypertension, angina, and thyrotoxicosis. It's available for oral use.

Signup and view all the flashcards

β-Blockers and Diabetes

Use caution with β-blockers in patients with diabetes because they can mask symptoms of hypoglycemia, such as increased heart rate.

Signup and view all the flashcards

Dual Action Beta Blocker

A type of beta blocker that affects both beta-1 receptors (heart rate) and alpha-1 receptors (vasoconstriction), providing dual antihypertensive effects

Signup and view all the flashcards

Labetalol

A dual action beta blocker that reduces heart rate (β1-receptor blockade) and dilates blood vessels (α1-receptor blockade), lowering blood pressure effectively.

Signup and view all the flashcards

Nursing Interventions for Adrenergic Blockers

Assess for allergies and pre-existing conditions, monitor apical pulse, BP, and side effects (like ED for some men). Avoid over-the-counter meds and monitor possible interactions.

Signup and view all the flashcards

Adrenergic Blockers - Abrupt Stopping

These medications should never be stopped abruptly, as it can cause serious health complications like rebound hypertension or heart problems.

Signup and view all the flashcards

Over-the-counter Medications and Adrenergic Blockers

Avoid using over-the-counter medications while taking adrenergic blockers because they can interact and cause unintended effects.

Signup and view all the flashcards

BPH Treatment: α-Blocker

Tamsulosin (Flomax®) is an α-blocker primarily used to treat benign prostatic hyperplasia (BPH) by relaxing the prostate and bladder muscles, improving urinary flow.

Signup and view all the flashcards

Contraindications: Tamsulosin

Tamsulosin should not be used in patients with known drug allergies, or concurrently with erectile dysfunction drugs like sildenafil.

Signup and view all the flashcards

β-Blockers: Mechanism

β-blockers reduce the effects of the sympathetic nervous system by blocking the action of norepinephrine and epinephrine at β-receptors, resulting in decreased heart rate, contractility, and blood pressure.

Signup and view all the flashcards

Nonselective β-Blockers

Nonselective β-blockers block both β1- and β2-receptors, affecting the heart and smooth muscle of bronchioles and blood vessels, causing bronchoconstriction and vasoconstriction.

Signup and view all the flashcards

β-Blocker Indications

β-blockers are used to treat conditions like angina, myocardial infarction, hypertension, dysrhythmias, and glaucoma (topical use).

Signup and view all the flashcards

β-Blocker Adverse Effects

Nonselective β-blockers can interfere with the body's response to hypoglycemia, masking symptoms such as tremors, tachycardia, and nervousness.

Signup and view all the flashcards

BPH Symptoms

Benign prostatic hyperplasia (BPH) causes enlargement of the prostate gland, leading to symptoms of urinary frequency, urgency, hesitancy, and weak stream.

Signup and view all the flashcards

α-Adrenergic Agonist

A drug that stimulates α-adrenergic receptors, causing vasoconstriction and other effects throughout the body.

Signup and view all the flashcards

What are some examples of α-adrenergic agonists used for conjunctival congestion relief?

Epinephrine, naphazoline hydrochloride, phenylephrine hydrochloride, and tetrahydrozoline are examples.

Signup and view all the flashcards

What is the primary effect of α-adrenergic agonists on blood vessels?

They cause vasoconstriction, which narrows blood vessels.

Signup and view all the flashcards

What are the main uses of vasoactive sympathomimetics like dopamine?

They are used to support the heart during cardiac failure or shock by affecting various receptors of the sympathetic nervous system.

Signup and view all the flashcards

How does dopamine affect blood flow at low doses?

It dilates blood vessels in the brain, heart, kidneys, and mesentery, increasing blood flow to these areas.

Signup and view all the flashcards

What is the primary role of epinephrine in emergency situations?

It's one of the main vasoactive drugs used in advanced cardiac life support protocols, acting on both α- and ß-adrenergic receptors of tissues innervated by the SNS.

Signup and view all the flashcards

What are the primary effects of norepinephrine on the cardiovascular system?

It stimulates α-adrenergic receptors, causing vasoconstriction, and directly stimulates β1-adrenergic receptors of the heart, increasing heart rate and contractility.

Signup and view all the flashcards

Why are adrenergic agonists sometimes associated with headache and restlessness?

They can cause these effects due to their actions on the central nervous system (CNS).

Signup and view all the flashcards

What are some common examples of drugs that can interact with adrenergic agonists?

Anaesthetic drugs, digoxin, tricyclic antidepressants, monoamine oxidase inhibitors (MAOIs), antihistamines, and thyroid preparations are examples.

Signup and view all the flashcards

What are some nursing implications when administering adrenergic agonists?

A comprehensive health history is essential to identify contraindications and potential drug interactions. Careful monitoring of vital signs, such as blood pressure and heart rate, is also crucial.

Signup and view all the flashcards

Study Notes

Autonomic Nervous System: Adrenergics

  • The sympathetic nervous system (SNS) has specific effects when stimulated by adrenergic drugs.
  • Adrenergic agonists (sympathomimetics) mimic the effects of SNS neurotransmitters (catecholamines). These include norepinephrine, epinephrine, and dopamine. Synthetic versions include dobutamine, phenylephrine hydrochloride.
  • Adrenergic receptors are categorized as α₁ and α₂ (presynaptic, controlling neurotransmitter release) and B₁ and β₂ (located in various organs and tissues).
  • a-adrenergic receptors, when stimulated, cause vasoconstriction of blood vessels, relaxation of GI smooth muscles, constriction of bladder sphincter, uterine contractions, male ejaculation, and dilation of pupils.
  • B₁-adrenergic receptors, when stimulated, increase the force and rate of heart contractions and AV node conduction.
  • B₂-adrenergic receptors, when stimulated, cause bronchodilation, uterine relaxation, glycogenolysis in the liver, increased renin in the kidneys, and decreased GI motility.
  • Direct-acting sympathomimetics bind directly to receptors and cause physiological responses.
  • Indirect-acting sympathomimetics cause the release of catecholamines from storage sites, then the catecholamines bind to receptors, resulting in physiological responses.
  • Specific drugs with their indications and adverse effects:
  • Epinephrine hydrochloride (Adrenalin®): Emergency situations, vasoconstriction, nonselective agonist, affecting α- and β-receptors
  • Norepinephrine betartrate (Levophed®): Treating hypotension and shock, vasoconstriction, direct-stimulating effects on heart (β₁-receptors), no effect on lung ß₂-receptors.
  • Dopamine hydrochloride: Potent dopaminergic, β₁ and α₁-adrenergic receptor activity, dilates blood vessels in brain, heart, and kidneys at low doses, increases cardiac contractility and output at higher doses, vasoconstriction at highest doses

Adrenergic Receptors

  • α₁-adrenergic receptors: Located on postsynaptic effector cells (muscle/organ the nerve stimulates).
  • α₂-adrenergic receptors: Located on presynaptic nerve terminals, controlling neurotransmitter release.
  • β₁-adrenergic receptors: Primarily located in the heart.
  • β₂-adrenergic receptors: Located in smooth muscles of the bronchioles, arterioles, and visceral organs.

Catecholamines

  • Endogenous catecholamines: epinephrine, norepinephrine, dopamine.
  • Synthetic catecholamines: dobutamine, phenylephrine hydrochloride

Mechanism of Action

  • Direct-acting sympathomimetics: Bind directly to receptors to cause physiological responses.
  • Indirect-acting sympathomimetics: Cause the release of catecholamines from storage sites, leading to physiological responses.

Drug Effects

  • Detail actions of several adrenergic agonists
  • Alpha (α) blockers: cause arterial and venous dilation, reducing peripheral vascular resistance. Used in treating hypertension and benign prostatic hyperplasia (BPH)

Indications

  • Bronchodilation with B₂-selective agonists like salbutamol, salmeterol, xinafoate, and terbutaline sulphate.
  • Conjunctival congestion relief with α-adrenergics
  • Glaucoma treatment (α-adrenergics) like dipivefrin hydrochloride
  • Support heart function during failure or shock with vasoactive sympathomimetics like dopamine and dobutamine.

Interactions

  • Potential interactions with anesthetic drugs, digoxin, tricyclic antidepressants, MAOIs, antihistamines, and thyroid preparations.

Nursing Implications

  • A complete health history and assessment for allergies, asthma, and cardiac, renal, and hepatic function are necessary.
  • Monitor therapeutic effects (edema, urinary output, vital signs).
  • Monitor patients for side effects (palpitations, dyspnea, nausea, vomiting).
  • Instruct patients to slowly change positions, avoid caffeine and alcohol, and notify physicians for any issues. Avoid OTC medications.
  • Know that adrenergic blockers have opposite effects of adrenergic drugs and are classified as antagonists. The classification is by the type of adrenergic receptor that it blocks (alpha 1, alpha 2, beta 1, beta 2).

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Quiz Team

Related Documents

Description

Explore the effects of adrenergic drugs on the sympathetic nervous system. This quiz covers the classifications of adrenergic receptors, their functions, and the impact of both natural and synthetic catecholamines on various physiological processes.

More Like This

Alpha and Beta Adrenergic Receptors Quiz
33 questions
Sympathetic Nervous System Quiz
47 questions

Sympathetic Nervous System Quiz

EffortlessDarmstadtium773 avatar
EffortlessDarmstadtium773
Use Quizgecko on...
Browser
Browser