12 Questions
What is the main reason for the body to establish self-tolerance mechanisms?
To avoid auto reactivity
Which autoimmune disease is mentioned as one of the earliest examples associated with the production of autoantibodies in a specific organ?
Hashimoto’s thyroiditis
What type of cells predominantly infiltrate the thyroid gland in Hashimoto’s thyroiditis?
Mononuclear phagocytes
What is a common outcome of Hashimoto's thyroiditis?
Goiter formation
Which demographic group is most commonly affected by Hashimoto’s thyroiditis?
Middle-aged women
What type of cells are notably found in extraordinary numbers within the infiltrated thyroid gland in Hashimoto's thyroiditis?
Plasma cells
What is a common feature of Hashimoto's disease involving thyroid follicles?
Regeneration
Which condition shows almost complete destruction and shrinking of the thyroid gland?
Primary myxoedema
Which antibodies are usually found in the serum of patients with Hashimoto's disease?
Antibodies to thyroglobulin
What organ does the serum from patients with systemic lupus erythematosus react with?
Many tissues in the body
What is a common shared characteristic of organ-specific autoimmune diseases?
Targeting specific organs like the thyroid and adrenals
What evidence suggests the role of genetic factors in autoimmune diseases?
Higher frequency of gastric autoantibodies in relatives of Hashimoto patients
Explore the association of autoimmunity with diseases and the breakdown of self-tolerance mechanisms in the immune system. Understand the risks of self-reactivity and self-recognition mechanisms.
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