Autoimmunity and Disease Association

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Questions and Answers

What is the main reason for the body to establish self-tolerance mechanisms?

  • To generate random specificities
  • To cause autoimmune diseases
  • To produce autoantibodies
  • To avoid auto reactivity (correct)

Which autoimmune disease is mentioned as one of the earliest examples associated with the production of autoantibodies in a specific organ?

  • Hashimoto’s thyroiditis (correct)
  • Lupus
  • Type 1 diabetes
  • Multiple sclerosis

What type of cells predominantly infiltrate the thyroid gland in Hashimoto’s thyroiditis?

  • Mononuclear phagocytes (correct)
  • Neutrophils
  • Dendritic cells
  • Eosinophils

What is a common outcome of Hashimoto's thyroiditis?

<p>Goiter formation (C)</p> Signup and view all the answers

Which demographic group is most commonly affected by Hashimoto’s thyroiditis?

<p>Middle-aged women (B)</p> Signup and view all the answers

What type of cells are notably found in extraordinary numbers within the infiltrated thyroid gland in Hashimoto's thyroiditis?

<p>Plasma cells (D)</p> Signup and view all the answers

What is a common feature of Hashimoto's disease involving thyroid follicles?

<p>Regeneration (B)</p> Signup and view all the answers

Which condition shows almost complete destruction and shrinking of the thyroid gland?

<p>Primary myxoedema (A)</p> Signup and view all the answers

Which antibodies are usually found in the serum of patients with Hashimoto's disease?

<p>Antibodies to thyroglobulin (B)</p> Signup and view all the answers

What organ does the serum from patients with systemic lupus erythematosus react with?

<p>Many tissues in the body (A)</p> Signup and view all the answers

What is a common shared characteristic of organ-specific autoimmune diseases?

<p>Targeting specific organs like the thyroid and adrenals (B)</p> Signup and view all the answers

What evidence suggests the role of genetic factors in autoimmune diseases?

<p>Higher frequency of gastric autoantibodies in relatives of Hashimoto patients (C)</p> Signup and view all the answers

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