Autoimmunity and Disease Association
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Questions and Answers

What is the main reason for the body to establish self-tolerance mechanisms?

  • To generate random specificities
  • To cause autoimmune diseases
  • To produce autoantibodies
  • To avoid auto reactivity (correct)
  • Which autoimmune disease is mentioned as one of the earliest examples associated with the production of autoantibodies in a specific organ?

  • Hashimoto’s thyroiditis (correct)
  • Lupus
  • Type 1 diabetes
  • Multiple sclerosis
  • What type of cells predominantly infiltrate the thyroid gland in Hashimoto’s thyroiditis?

  • Mononuclear phagocytes (correct)
  • Neutrophils
  • Dendritic cells
  • Eosinophils
  • What is a common outcome of Hashimoto's thyroiditis?

    <p>Goiter formation</p> Signup and view all the answers

    Which demographic group is most commonly affected by Hashimoto’s thyroiditis?

    <p>Middle-aged women</p> Signup and view all the answers

    What type of cells are notably found in extraordinary numbers within the infiltrated thyroid gland in Hashimoto's thyroiditis?

    <p>Plasma cells</p> Signup and view all the answers

    What is a common feature of Hashimoto's disease involving thyroid follicles?

    <p>Regeneration</p> Signup and view all the answers

    Which condition shows almost complete destruction and shrinking of the thyroid gland?

    <p>Primary myxoedema</p> Signup and view all the answers

    Which antibodies are usually found in the serum of patients with Hashimoto's disease?

    <p>Antibodies to thyroglobulin</p> Signup and view all the answers

    What organ does the serum from patients with systemic lupus erythematosus react with?

    <p>Many tissues in the body</p> Signup and view all the answers

    What is a common shared characteristic of organ-specific autoimmune diseases?

    <p>Targeting specific organs like the thyroid and adrenals</p> Signup and view all the answers

    What evidence suggests the role of genetic factors in autoimmune diseases?

    <p>Higher frequency of gastric autoantibodies in relatives of Hashimoto patients</p> Signup and view all the answers

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