Autoimmune Hepatitis Quiz

What is the main characteristic of autoimmune hepatitis?

Which type of autoimmune hepatitis is associated with antinuclear antibodies (ANAs) and anti-smooth muscle antibodies (ASMAs)?

What is the prevalence of autoimmune hepatitis?

Which antibodies are characteristic of Type 2 AIH?

Which age range shows a bimodal distribution for autoimmune hepatitis?

Which type of autoimmune hepatitis is most common in children?

Which of the following autoimmune conditions is commonly associated with idiopathic autoimmune hepatitis?

What are the common nonspecific symptoms of autoimmune hepatitis?

What signs may indicate acute liver failure in autoimmune hepatitis?

Which laboratory test results are typically elevated in autoimmune hepatitis?

When should liver biopsy be performed to confirm the diagnosis of autoimmune hepatitis?

What is the first-line induction therapy for autoimmune hepatitis?

What is the 10-year survival rate with treatment for autoimmune hepatitis?

Characteristics of Autoimmune Hepatitis

The main characteristic of autoimmune hepatitis is the immune system's attack on the liver cells, causing inflammation and damage.

Type 1 Autoimmune Hepatitis

Type 1 autoimmune hepatitis is associated with antinuclear antibodies (ANAs) and anti-smooth muscle antibodies (ASMAs).

Prevalence and Distribution

The prevalence of autoimmune hepatitis is unknown, but it has a bimodal distribution, affecting mainly young women in their teens and twenties, and women in their fifties and sixties.

Type 2 Autoimmune Hepatitis

Type 2 autoimmune hepatitis is characterized by the presence of liver-kidney microsomal antibodies (LMK-1) and liver cytosol antibodies (LC-1).

Autoimmune Hepatitis in Children

Type 1 autoimmune hepatitis is the most common type in children.

Associated Conditions

Idiopathic autoimmune hepatitis is often associated with other autoimmune conditions, such as rheumatoid arthritis, thyroiditis, and ulcerative colitis.

Symptoms and Signs

Common nonspecific symptoms of autoimmune hepatitis include fatigue, loss of appetite, nausea, vomiting, and abdominal discomfort.
Signs that may indicate acute liver failure include jaundice, dark urine, and pale stools.

Laboratory Tests

Laboratory test results typically elevated in autoimmune hepatitis include transaminases (ALT and AST), gamma-globulins, and IgG levels.

Diagnosis

Liver biopsy should be performed to confirm the diagnosis of autoimmune hepatitis, especially if laboratory tests are inconclusive.

Treatment

The first-line induction therapy for autoimmune hepatitis is corticosteroids, which can induce remission in 80% of patients.
With treatment, the 10-year survival rate for autoimmune hepatitis is around 90%.

Test your knowledge about autoimmune hepatitis, a disease characterized by immunemediated liver injury, serum antibodies, peripheral blood T lymphocytes, association with other autoimmune diseases, and high levels of serum immunoglobulins.