10 Questions
Which enzyme is responsible for the synthesis of Prostaglandins and Thromboxane A2?
Cyclooxygenase
Which of the following mediators is a product of the LOX pathway?
Leukotrienes
Which of the following drugs blocks the Leukotriene receptor?
Montelukast
Which prostaglandin has a bronchoconstrictive effect?
PGF2
Which of the following is a pharmacological action of Prostaglandins?
Elevates the thermostatic set point in the hypothalamus
Prostaglandins can only be produced through the COX pathway
False
Leukotrienes are products of the COX pathway
False
Corticosteroids are produced by lipocortin
True
Nonsteroidal anti-inflammatory drugs inhibit phospholipase A2
True
Thromboxane A2 causes bronchodilation
False
Study Notes
Autacoids
- Autacoids are biologically active substances produced by a variety of cells that act on or nearby the tissue that produces them.
- They are also referred to as "local hormones".
- Autacoids differ from circulating hormones in that they are produced by many tissues rather than in specific endocrine glands.
Types of Autacoids
- Lipids: Eicosanoids (prostaglandins, thromboxane, and leukotrienes), platelet activating factor
- Amines: Histamine and serotonin (5-hydroxytryptamine; "5-HT")
- Gases: Nitric oxide
- Peptides: angiotensin, Kinins (bradykinin), Neuropeptides (substance P), Cytokines
Eicosanoids
- Eicosanoids are a group of biologically active substances derived from arachidonic acid.
- Arachidonic acid is composed of 20 carbon atoms (hence the name "eicosa").
- Eicosanoids act via G-protein coupled receptors.
Test your knowledge of autacoids and their classification in pharmacology with this quiz. Explore the different types of autacoids and their physiological roles in the body.
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