AUD Pharmacotherapy Goals and Treatment Strategies

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Questions and Answers

Match the goals of AUD pharmacotherapy with their descriptions:

Prevent/Treat withdrawal seizures = Use of long-acting benzodiazepines Prevent relapse = Use of Mu Opioid Antagonist Treat comorbid conditions = Management of additional mental health issues Prevent/treat withdrawal = Use of anticonvulsants

Match the medications to their specific usage:

Disulfiram (Antabuse) = Inhibit Aldehyde Dehydrogenase Naltrexone (ReVia, Trexan) = Prevent relapse Diazepam = Long-acting benzodiazepine for withdrawal Lamotrigine = Anticonvulsant for seizure prevention

Match the type of pharmacotherapy with its characteristics:

Disulfiram = Low patient compliance Naltrexone = Better than placebo Calcium Carbamide (Temposil) = Prolongs unpleasant effects of drinking Topiramate = Used for seizure prevention

Match the medications with their effects or actions:

<p>Naltrexone = Mu Opioid Antagonist Diazepam = Prevention of withdrawal seizures Lamotrigine = Anticonvulsant action Disulfiram = Inhibits aldehyde metabolism</p> Signup and view all the answers

Match the treatment goals with their respective medications:

<p>Prevent relapse = Naltrexone Prevent/treat withdrawal seizures = Diazepam Treat comorbid conditions = Various antidepressants Prevent withdrawal = Anticonvulsants</p> Signup and view all the answers

Flashcards

AUD Pharmacotherapy Goals

The goals of AUD (alcohol use disorder) pharmacotherapy are to prevent and treat withdrawal symptoms, seizures, relapse, and comorbid conditions.

Withdrawal Seizure Prevention

Withdrawal seizures are prevented with long-acting benzodiazepines (like Diazepam) and anticonvulsants (like Lamotrigine and Topiramate).

Relapse Prevention Methods

Disulfiram (Antabuse) and Calcium Carbamide (Temposil) aim to deter relapse. Naltrexone (ReVia, Trexan) is a mu opioid antagonist, more effective than placebo, and injections are potentially most effective.

Disulfiram's Action

Disulfiram inhibits Aldehyde Dehydrogenase, which results in unpleasant effects from alcohol consumption, deterring relapse.

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Naltrexone's Mechanism

Naltrexone is a mu opioid antagonist, blocking the effects of opioid substances and potentially preventing relapse.

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Study Notes

Goals of AUD Pharmacotherapy

Prevent and treat withdrawal symptoms, including seizures.
Prevent relapse.
Treat co-occurring conditions (comorbid).

Preventing/Treating Withdrawal Seizures

Long-acting benzodiazepines, such as diazepam, can be used.
Anticonvulsants like lamotrigine and topiramate are also effective.

Preventing Relapse

Disulfiram (Antabuse) and calcium carbimide (Temposil) inhibit aldehyde dehydrogenase, prolonging the unpleasant effects of alcohol consumption.
Patient compliance with disulfiram is often low.
Naltrexone (ReVia, Trexan) is a mu opioid antagonist.
Naltrexone is more effective than placebo.
Naltrexone injections may be more effective than oral versions.