Asthma/COPD Medications Overview
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Questions and Answers

What is the recommended action for cleaning the mouthpiece of an MDI?

  • Use alcohol to sanitize
  • Soak in warm water
  • Skip cleaning unless it's visibly dirty
  • Clean with water (correct)

What is true about Beclomethasone (QVAR RediHaler)?

  • It is a DPI formulation
  • It requires shaking before use
  • It can be used without holding the breath
  • It is breath-actuated and doesn't need priming (correct)

Which medication is classified as a SABA?

  • Fluticasone
  • Mometasone
  • Budesonide
  • Albuterol (correct)

Which of the following is the first line therapy for persistent asthma?

<p>Inhaled corticosteroids (ICS) (D)</p> Signup and view all the answers

What is the recommended discarding timeframe for Mometasone (Asmanex Twisthaler) after removing from its pouch?

<p>45 days (D)</p> Signup and view all the answers

What is a potentially adverse effect of SABA medications like Albuterol?

<p>Hypokalemia (B)</p> Signup and view all the answers

Which of the following statements is true regarding the use of Terbutaline?

<p>It is available in both oral and injectable forms (C)</p> Signup and view all the answers

How long should Levabuterol (Xopenex) in a nebulizer solution be used after opening?

<p>1 week if removed from pouch (C)</p> Signup and view all the answers

Which of the following is a systemic steroid that can be used for acute treatment with SABAs?

<p>Prednisone (C)</p> Signup and view all the answers

What is a common side effect associated with the use of prednisone?

<p>Hypokalemia (B)</p> Signup and view all the answers

Which of these medications should never be used alone in asthma treatment?

<p>Salmeterol (B)</p> Signup and view all the answers

What formulation of montelukast can be given in chewable form?

<p>Singulair (C)</p> Signup and view all the answers

Which systemic steroid has a delayed-release formulation called Rayos?

<p>Prednisone (B)</p> Signup and view all the answers

What is a significant dietary consideration for zafirlukast (Accolate)?

<p>Take on an empty stomach (C)</p> Signup and view all the answers

Which medication is a pathway antagonist used as an anti-leukotriene?

<p>Zileuton (B)</p> Signup and view all the answers

What potential behavioral side effect is associated with montelukast?

<p>Mood and behavior changes (C)</p> Signup and view all the answers

What is the primary use of Omalizumab (Xolair)?

<p>Allergic asthma and chronic idiopathic urticaria (A)</p> Signup and view all the answers

Which medication is classified as a long-acting beta agonist (LABA)?

<p>Formoterol (A)</p> Signup and view all the answers

What is the mechanism of action of Theophyllines?

<p>Phosphodiesterase inhibition (A)</p> Signup and view all the answers

Which interleukin receptor antagonist is administered subcutaneously?

<p>Benralizumab (A), Mepolizumab (D)</p> Signup and view all the answers

Which condition is treated with nasal corticosteroids?

<p>Allergic rhinitis (B)</p> Signup and view all the answers

What is a common side effect associated with Roflumilast (Daliresp)?

<p>Suicidal thoughts (C)</p> Signup and view all the answers

Which anticholinergic inhaler is administered via soft mist?

<p>Tiotropium (A)</p> Signup and view all the answers

What is the recommended dosing frequency for Budesonide nasal spray?

<p>Once daily (C)</p> Signup and view all the answers

Which medication combination is found in Breztri Aerosphere?

<p>Budesonide / Glycopyrrolate / Formoterol (D)</p> Signup and view all the answers

Which of the following is NOT a characteristic of mast cell stabilizers?

<p>Immediate relief of asthma symptoms (C)</p> Signup and view all the answers

Flashcards

Pro-drug

A type of medication that is inactive when swallowed but becomes active after being broken down in the body, often in the lungs. This can help reduce oral thrush, a common side effect of some medications.

Systemic Steroids

A type of medication used to treat asthma and other inflammatory conditions. They work by suppressing the immune system and reducing inflammation.

LABAs (Long-Acting Beta-Agonists)

A type of medication used to manage asthma symptoms. Long-acting beta-agonists (LABAs) work by relaxing the muscles in the airways, making it easier to breathe. However, they should never be used alone and must always be combined with inhaled corticosteroids (ICS).

Anti-leukotrienes

A group of medications that block the action of leukotrienes, chemicals that contribute to asthma symptoms. Anti-leukotrienes can reduce inflammation and improve breathing.

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Montelukast (Singulair)

A specific anti-leukotriene medication that comes in chewable tablets, regular tablets, and granules. Granules should be mixed with solids before administration. It should be taken once a day at bedtime.

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Zafirlukast (Accolate)

A specific anti-leukotriene medication that is taken twice a day on an empty stomach. It is available in 10 mg or 20 mg doses.

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Zileuton (Zyflo, Zyflo CR)

A specific anti-leukotriene medication that is taken twice a day with food. Its controlled-release version (Zyflo CR) is also available.

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What are SABAs?

Short-acting beta-agonist inhalers used to relieve asthma symptoms quickly. These medications are typically used for 'rescue' when needed.

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What are the two main types of asthma inhalers?

MDIs (metered-dose inhalers) are used to deliver a specific amount of medication with each puff. DPIs (dry powder inhalers) use a powder that is inhaled. Both methods deliver medication to the lungs.

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What is the most common SABA used for asthma?

Albuterol is a common SABA used to relieve asthma symptoms quickly. It is available in both MDI and DPI forms. The MDI form is most widely used for treating asthma attacks.

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Why is a spacer recommended for MDIs?

The medication delivered by an MDI is more likely to actually reach the lungs when a spacer is used. This is because the spacer gives the medication a chance to slow down and distribute better.

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What are ICS?

These inhalers, known as inhaled corticosteroids, are the first line of defense for treating persistent asthma. Their primary role is to reduce inflammation in the airways. Most are taken twice a day (BID).

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What's special about Beclomethasone?

Beclomethasone is an ICS that comes in a ready-to-use inhaler called QVAR RediHaler. This type of inhaler is unique as it does not require shaking, priming, or a spacer.

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What is unique about Budesonide?

Budesonide is another ICS available in both DPI (Pulmicort Flexhaler) and nebulizer (Pulmicort Respules) forms. The nebulizer version makes it the only steroid suitable for use in children as young as 1 year old.

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What are some common ICS medications?

Inhaled corticosteroids like fluticasone are often prescribed for long-term asthma management. They are available in both MDI and DPI forms. The DPI form, like Flovent Diskus, offers a more convenient way to administer the medication.

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Omalizumab (Xolair)

An anti-IgE monoclonal antibody used subcutaneously for allergic asthma and chronic idiopathic urticaria. It binds to IgE, preventing it from triggering allergic reactions.

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Interleukin-5 Receptor Antagonists

A group of medications that block the interleukin-5 receptor, which is involved in the production of eosinophils. They are used for eosinophilic asthma.

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Theophylline

A PDE inhibitor, not typically used first-line or long-term due to side effects and monitoring requirements. Acts like caffeine and is available orally or intravenously.

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Anticholinergic Inhalers

A class of medications that block muscarinic receptors, making airways wider. Used for COPD and available in inhalers.

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LABA

A class of long-acting beta agonists (LABA) used for COPD. They are all "terol" medications and have various formulations and combinations for specific needs.

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Vilanterol

A long-acting beta agonist (LABA) used in combination with other medications for COPD.

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Roflumilast (Daliresp)

A PDE4 inhibitor primarily considered last-line therapy for COPD. It has serious side effects like suicide risk and weight loss.

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Nasal Corticosteroids

A class of nasal medications that reduce inflammation and are effective for allergic rhinitis. They are mostly available over-the-counter.

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Tiotropium

A long-acting muscarinic antagonist used for COPD.

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Aclidinium (Tudorza Pressair)

A long-acting muscarinic antagonist used for COPD. It comes in a DPI capsule form with a special mechanism.

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Study Notes

Asthma/COPD Medications

  • SABA (Short-Acting Beta2-Agonists):

    • Albuterol is the most common SABA
    • Available as metered-dose inhalers (MDIs) often with a spacer.
    • Inhalers should be shaken and primed.
    • Use slow and deep breaths
    • Clean mouthpieces with water.
  • LABA (Long-Acting Beta2-Agonists):

    • Used for maintenance therapy
    • Examples include Olodaterol and Salmeterol, often combined with other medications
    • Generally administered once daily
    • Consider different inhaler types (Soft mist, DPI, etc.)
  • ICS (Inhaled Corticosteroids):

    • First-line therapy for persistent asthma.
    • Examples include Beclomethasone, Budesonide, Fluticasone.
    • Often used with a spacer and proper technique is important.
    • Typically administered twice daily
    • Take with inhaler technique instruction.
  • Systemic Steroids:

    • Used for short-term, severe exacerbations.
    • Examples include Prednisone, Prednisolone.
    • Prescribed based on specific circumstances.
  • Anti-Leukotrienes:

    • Used to control inflammation and reduce symptoms.
    • Example is Montelukast taken once daily
  • Other medications:

    • Other medications such as Zileuton, which inhibit the action of leukotrienes, and Mometasone are also included for treatment.
    • Omalizumab (Xolair) is administered subcutaneously and targets IgE.

Systemic Steroids

  • Used for acute, short-term treatment.
  • Examples include Prednisone, Prednisolone, and Dexamethasone.
  • Often used in courses rather than continuous therapy.
  • Potential side effects include electrolyte imbalances and increased risk of infections.
  • Specific dosage and duration vary based on the patient and the condition.

Nasal Corticosteroids

  • Used for allergic rhinitis.
  • Examples include Fluticasone, Mometasone, and Budesonide.
  • Typically administered as nasal sprays.

Other Nasal Sprays

  • Include olopatadine and azelastine.
  • Often used for symptomatic relief of nasal allergies.

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Asthma/COPD PDF

Description

Test your knowledge on the various medications used to treat asthma and COPD, including SABA, LABA, ICS, and systemic steroids. Understand their uses, administration techniques, and important considerations for effective treatment. This quiz will help reinforce your understanding of the pharmacologic management of respiratory diseases.

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