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You are seeing an asthmatic patient and decide to prescribe Indacaterol. She asks how this bronchodialator medication works. How would you explain it to her?
You are seeing an asthmatic patient and decide to prescribe Indacaterol. She asks how this bronchodialator medication works. How would you explain it to her?
- Inhibits M3-Gq-PLC-IP3-Ca2+ Pathway
- Gs + adenylate cyclase --> INC cAMP --> INC Protein Kinase A --> Phosphorylates (inactive) Gi --> Decreases [Ca2+] --> Inhibits myosin light chain phosphorylation --> DEC contraction (correct)
- Binds to glucocorticoid receptors --> INC transcription of anti-inflammatory genes & DEC transcription of inflammatory genes
- Inhibits PD3, Antagonizes Adenosine & Increases IL-10
Which medications are both leukotriene receptor antagonists and inhibitors of 5'lipoxygenase by binding to D4 + E4 and blocking the receptor activation & preventing the formation of leukotrienes LTB4, LTC4, LTD4, & LTE4?
Which medications are both leukotriene receptor antagonists and inhibitors of 5'lipoxygenase by binding to D4 + E4 and blocking the receptor activation & preventing the formation of leukotrienes LTB4, LTC4, LTD4, & LTE4?
- Bronchodilators (Albuterol, Salmeterol)
- Corticosteroids (Hydrocortisone, Fluticasone, Budesonide)
- Antileukotrienes (Montelukast, Zileuton) (correct)
- Anticholinergics
What is the mechanism of action for the methylxanthine medication Theophylline
What is the mechanism of action for the methylxanthine medication Theophylline
- Inhibits PD3, Antagonizes Adenosine & Increases IL-10 (correct)
- Inhibits M3-Gq-PLC-IP3-Ca2+ Pathway
- Binds to glucocorticoid receptors --> INC transcription of anti-inflammatory genes & DEC transcription of inflammatory genes
- Gs + adenylate cyclase --> INC cAMP --> INC Protein Kinase A --> Phosphorylates (inactive) Gi --> Decreases [Ca2+] --> Inhibits myosin light chain phosphorylation --> DEC contraction
Immunomodulator Omalizumab controls severe allergic asthma by doing what?
Immunomodulator Omalizumab controls severe allergic asthma by doing what?
Corticosteroids such as beclomethasone dipropionate and prednisone have what mechanism of action?
Corticosteroids such as beclomethasone dipropionate and prednisone have what mechanism of action?
You are seeing a patient with COPD who complains of symptoms when exercising. You are thinking of prescribing a certain medication that works how?
You are seeing a patient with COPD who complains of symptoms when exercising. You are thinking of prescribing a certain medication that works how?
Cromolyn is a degranulation inhibitor that works how?
Cromolyn is a degranulation inhibitor that works how?
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