Pulmonary Pharmacology
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Questions and Answers

You are seeing an asthmatic patient and decide to prescribe Indacaterol. She asks how this bronchodialator medication works. How would you explain it to her?

  • Inhibits M3-Gq-PLC-IP3-Ca2+ Pathway
  • Gs + adenylate cyclase --> INC cAMP --> INC Protein Kinase A --> Phosphorylates (inactive) Gi --> Decreases [Ca2+] --> Inhibits myosin light chain phosphorylation --> DEC contraction (correct)
  • Binds to glucocorticoid receptors --> INC transcription of anti-inflammatory genes & DEC transcription of inflammatory genes
  • Inhibits PD3, Antagonizes Adenosine & Increases IL-10

    • Which medications are both leukotriene receptor antagonists and inhibitors of 5'lipoxygenase by binding to D4 + E4 and blocking the receptor activation & preventing the formation of leukotrienes LTB4, LTC4, LTD4, & LTE4?

  • Bronchodilators (Albuterol, Salmeterol)
  • Corticosteroids (Hydrocortisone, Fluticasone, Budesonide)
  • Antileukotrienes (Montelukast, Zileuton) (correct)
  • Anticholinergics

    • What is the mechanism of action for the methylxanthine medication Theophylline

  • Inhibits PD3, Antagonizes Adenosine & Increases IL-10 (correct)
  • Inhibits M3-Gq-PLC-IP3-Ca2+ Pathway
  • Binds to glucocorticoid receptors --> INC transcription of anti-inflammatory genes & DEC transcription of inflammatory genes
  • Gs + adenylate cyclase --> INC cAMP --> INC Protein Kinase A --> Phosphorylates (inactive) Gi --> Decreases [Ca2+] --> Inhibits myosin light chain phosphorylation --> DEC contraction

    • Immunomodulator Omalizumab controls severe allergic asthma by doing what?

    <p>Blocking the binding of IgE</p> Signup and view all the answers

    Corticosteroids such as beclomethasone dipropionate and prednisone have what mechanism of action?

    <p>Binds to glucocorticoid receptors --&gt; INC transcription of anti-inflammatory genes &amp; DEC transcription of inflammatory genes</p> Signup and view all the answers

    You are seeing a patient with COPD who complains of symptoms when exercising. You are thinking of prescribing a certain medication that works how?

    <p>Anticholinergics - Inhibits M3-Gq-PLC-IP3-Ca2+ Pathway</p> Signup and view all the answers

    Cromolyn is a degranulation inhibitor that works how?

    <p>Inhibits mast cell degranulation &amp; the release of histamine &amp; leukotrienes</p> Signup and view all the answers

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